L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department

British Journal of Haematology

Volumn 120, Issue 3, 2003, Pages 532-534

  Lopez, Bernard L ^a   Kreshak, Allyson A ^a   Morris, Claudia R ^b   Davis Moon, Linda ^a   Ballas, Samir K ^a   Ma, Xin Liang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

L arginine; Nitric oxide; Nitric oxide metabolites; Sickle cell anaemia; Vasoocclusive crisis

Indexed keywords

ARGININE; HYDROXYUREA;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BETA THALASSEMIA; BLOOD VESSEL OCCLUSION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EMERGENCY WARD; HUMAN; MAJOR CLINICAL STUDY; PAIN ASSESSMENT; PRIORITY JOURNAL; SICKLE CELL ANEMIA; STEADY STATE;

ACUTE DISEASE; ADULT; ANEMIA, SICKLE CELL; ARGININE; BIOLOGICAL MARKERS; CONSTRICTION, PATHOLOGIC; HUMANS; NITRIC OXIDE; PAIN MEASUREMENT; VASCULAR DISEASES;

EID: 0037323910     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04109.x     Document Type: Article

References (12)

1. Arnal, J.-F., Munzel, T., Venema, R.C., James, N.L., Bai, C.L., Mitch, W.E. & Harrison, D.G. (1995) Interactions between L-arginine and L-glutamine change endothelial NO production: an effect independent of NO synthase substrate availability. Journal of Clinical Investigation, 95, 2565-2572.
2. Bode-Boger, S.M., Boger, R.H., Kienke, S., Junker, W. & Frolich, J.C. (1996) Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochemical and Biophysical Research Communication, 219, 598-603.
3. Creager, M.A., Gallagher, S.J., Girerd, X.J., Coleman, S.M., Dzau, V.J. & Cooke, J.P. (1992) L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. Journal of Clinical Investigation, 90, 1248-1253.
4. Drexler, H., Fischell, T.A., Pinto, F.J., Chenzbraun, A., Botas, J., Cooke, J.P. & Alderman, E.L. (1994) Effect of L-arg on coronary endothelial function in cardiac transplant recipients. Circulation, 89, 1615-1623.
5. Enwonwu, C.O. (1989) Increased metabolic demand for arginine in sickle cell anaemia. Medical Science Research, 17, 9978-9998.
6. Gladwin, M.T. & Schechter, A. (2001) Nitric oxide therapy in sickle cell disease. Seminars in Hematology, 38, 333-342.
7. Lerman, A., Burnett, J.C., Higano, S.T., McKinley, L.J. & Holmes, D.R. (1998) Long-term L-arg supplementation improves small-vessel coronary endothelial function in humans. Circulation, 97, 2123-2128.
8. Lopez, B.L., Davis-Moon, L., Ballas, S.K. & Ma, X.L. (2000) Sequential nitric oxide measurement during the emergency department treatment of acute vasooclusive sickle cell crisis. American Journal of Hematology, 64, 15-19.
9. Morris, C.R., Kuypers, F., Larkin, S., Kennedy, N., Simon, J., Vichinsky, E. & Styles, L. (2000a) Patterns of arginine and nitric oxide in patients with sickle cell disease with vasoocclusive crisis and acute chest syndrome. Journal of Pediatric Hematology and Oncology, 22, 515-520.
10. Morris, C.R., Kuypers, F., Larkin, S., Kennedy, N., Simon, J., Vichinsky, E. & Styles, L. (2000b) Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. British Journal of Haematology, 111, 498-500.
11. Mosseri, M., Bartlett-Pandite, A.N., Wenc, K., Isner, J.M. & Weinstein, R. (1993) Inhibition of endothelium-dependent vasorelaxation by sickle erythrocytes. American Heart Journal, 126, 338-346.
12. Todd, K.H., Funk, K.G., Funk, J.P. & Bonacci, R. (1996) Clinical significance of reported changes in pain severity. Annals of Emergency Medicine, 27, 485-489.