Synthesis and biological evaluation of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines as new ligands of central and peripheral benzodiazepine receptors

Farmaco

Volumn 58, Issue 2, 2003, Pages 129-140

  Campagna, Francesco ^a   Palluotto, Fausta ^a   Mascia, Maria Paola ^b   Maciocco, Elisabetta ^b   Marra, Carla ^b   Carotti, Angelo ^a   Carrieri, Antonio ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Binding assay; Indeno 1,2 c pyridazines; Peripheral benzodiazepine receptor; Pyridazino 4,3 b indoles; Structure activity relationships

Indexed keywords

2 PHENYL 2H INDENO[1,2 C]PYRIDAZINE 3,5 DIONE; 2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 3 PHENYL 5 ETHYL 5H PYRIDAZINO[4,3 B]INDOLE 4 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; ESTER DERIVATIVE; INDOLE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NF 182; PYRIDAZINE DERIVATIVE; RO 54864; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; MALE; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 0037322297     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)00017-4     Document Type: Article

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