The combined effects of garlic oil and fish oil on the hepatic antioxidant and drug-metabolizing enzymes of rats

British Journal of Nutrition

Volumn 89, Issue 2, 2003, Pages 189-200

  Chen, Haw Wen ^a   Tsai, Chia Wen ^a   Yang, Jaw Ji ^a   Liu, Cheng Tze ^a   Kuo, Wei Wen ^a   Lii, Chong Kuei ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidant enzymes; Cytochrome P450; Fish oil; Garlic oil

Indexed keywords

ANTIOXIDANT; CORN OIL; CYTOCHROME P450 1A1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; ERYTHROMYCIN DEMETHYLASE; ETHOXYRESORUFIN DEETHYLASE; FATTY ACID; FISH OIL; GARLIC OIL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; ISOENZYME; LIPID; LIVER ENZYME; MESSENGER RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET; ENZYME ACTIVITY; ENZYME METABOLISM; FAT INTAKE; FATTY ACID ANALYSIS; FEEDING; IMMUNOBLOTTING; LIPID BLOOD LEVEL; MALE; MODULATION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ALLYL COMPOUNDS; ANIMALS; ANTIOXIDANTS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY FATS; FATTY ACIDS; FISH OILS; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LIVER; MALE; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; SULFIDES; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

ALLIUM SATIVUM; ANIMALIA; ZEA MAYS;

EID: 0037321247     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2002766     Document Type: Article

References (51)

1. Agarwal KC (1996) Therapeutic actions of garlic constituents. Medicinal Research Review 16, 111-124.
2. Alder AJ & Holub BJ (1997) Effect of garlic-oil and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. American Journal of Clinical Nutrition 65, 445-450.
3. Bang HO, Dyerberg J & Sinclair HM (1980) The composition of the Eskimo Food in north western Greenland. American Journal of Clinical Nutrition 33, 2657-2661.
4. Bellomo G, Mirabelli F, DiMonte D, Richelmi P, Thor H, Orrenius C & Orrenius S (1987) Formation and reduction of glutathione-mixed disulfides during oxidative stress. Biochemical Pharmacology 36, 1313-1320.
5. Bergelson S, Pinkus R & Daniel V (1994) Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression. Oncogene 9, 565-571.
6. Catignani GL & Bieri JG (1983) Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography. Clinical Chemistry 29, 708-712.
7. Chen HW, Yang JJ, Tsai CW, Wu JJ, Sheen LY, Ou CC & Lii CK (2001) Dietary fat and garlic oil independently regulate hepatic cytochrome P450 2B1 and the placental form of glutathione S-transferase expression in rats. Journal of Nutrition 131, 1438-1443.
8. Conney AH (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes memorial lecture. Cancer Research 42, 4875-4917.
9. Crosby AJ, Wahle KW & Duthie GG (1996) Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. Biochimica et Biophysica Acta 1303, 187-192.
10. Cross CE, Halliwell B, Borish ET, Pryon WA, Ames BN, Saul RL, McCord JM & Harman D (1987) Oxygen radicals and human disease. Annals of Internal Medicine 107, 526-545.
11. Dyerberg J, Bang HO & Hjørne N (1975) Fatty acids composition of the plasma lipids in Greenland Eskimos. American Journal of Clinical Nutrition 28, 958-966.
12. Fang JL, Vaca CE, Valsta LM & Mutanen M (1996) Determination of DNA adducts of malondialdehyde in humans: Effects of dietary fatty acids consumption. Carcinogenesis 17, 1035-1040.
13. Fernanes G, Chandrasekar B, Luan X & Troyer DA (1996) Modulation of antioxidant enzymes and programmed cell death by n-3 fatty acids. Lipids 31, S91-S96.
14. Fleischhauer AT & Arab L (2001) Garlic and cancer: A critical review of the epidemiologic literature. Journal of Nutrition 131, 1032S-1040S.
15. Folch J, Lees M & Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497-509.
16. Fotouhi-Ardakani N & Batist G (1999) Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Biochemical Journal 339, 685-693.
17. Fox PL & DiCorleto PE (1988) Fish oil inhibits endothelial cell production of platelet-derived growth factor-like protein. Science 241, 453-456.
18. Fraga CG, Leibovitz BE & Tappel AL (1988) Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: Characterization and comparison with homogenates and microsomes. Free Radical Biology and Medicine 4, 155-161.
19. Goodnight SH Jr, Harris WS, Connor WE & Illingworth DR (1982) Polyunsaturated fatty acids, hyperlipidemia and thrombosis. Arteriosclerosis 2, 87-113.
20. Guengerich FP (1991) Oxidation of toxic and carcinogenic chemicals by human cythrome P-450 enzymes. Chemical Research in Toxicology 4, 391-407.
21. Guengerich FP (1995) Influence of nutrients and other dietary materials on the cytochrome P-450 enzymes. American Journal of Clinial Nutrition 61, 651S-658S.
22. Habig WH, Pabst MJ & Jakoby WB (1974) Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 249, 7130-7139.
23. Hwang D & Rhee SH (1999) Receptor-mediated signaling pathways: Potential targets of modulation by dietary fatty acids. American Journal of Clinical Nutrition 70, 545-556.
24. Iqbal M & Athar M (1998) Attenuation of iron-nitrilotriacetate (Fe-NTA)-mediated renal oxidative stress, toxicity and hyperproliferative response by the prophylactic treatment of rats with garlic oil. Food and Chemical Toxicology 36, 485-495.
25. Jump DB (2002) Dietary polyunsaturated fatty acids and regulation of gene expression. Current Opinion in Lipidology 13, 155-164.
26. Laemmli UK Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277, 680-685.
27. Lawrence RA & Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochemical and Biophysics Research Communication 71, 952-958.
28. Leclercq I, Horsmans Y, Desager JP, Delzenne N & Geubel AP (1998) Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation. Journal of Hepatology 28, 410-416.
29. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ & Robertson GR (2000) CYP 2E1 and CYP 4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. Journal of Clinical Investigation 105, 1067-1075.
30. Lepage G & Roy CC (1986) Direct transesterification of all classes of lipids in one-step reaction. Journal of Lipid Research 27, 114-120.
31. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ (1951) Protein measurement with Folin phenol reagent. Journal of Biological Chemistry 193, 265-275.
32. Machlin ZJ & Bendich A (1987) Free radicals tissue damage: Protective role for antioxidant nutrients. FASEB Journal 1, 441-445.
33. Morcos NC (1997) Modulation of lipid profile by fish oil and garlic combination. Journal of the National Medical Association 89, 673-678.
34. Nash T (1953) The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical Journal 55, 416-421.
35. National Research Council (1985) Guide for the Care and Use of Laboratory Animals. Publication No. 85-23 (Rev.). Bethesda, MD: National Institutes of Health.
36. Phelps S & Harris WS (1993) Garlic supplementation and lipoprotein oxidation susceptibility. Lipids 28, 475-477.
37. Poul RJ & Fouts JR (1980) A rapid method for assaying the metabolism of 7-ethoxyresorufin subcellular fractions. Analytical Biochemistry 107, 150-155.
38. Rahman K (2001) Historical perspective on garlic and cardiovascular disease. Journal of Nutrition 313, 977S-979S.
39. Reddy BS & Surgi S (1988) Effect of different levels of omega-3 and omega-6 fatty a cids on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Research 48, 6642-6647.
40. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW & Potter DW (1994) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Analytical Biochemistry 106, 55-62.
41. Ruiz-Gutiérrez V, Pérez-Espinosa A, Vázquez CM & Santa-Mariá C (1999) Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver. British Journal of Nutrition 82: 233-241.
42. Rushmore TH, Pickett CB (1990) Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Journal of Biological Chemistry 165, 14648-14653.
43. Sheen LY, Chen HW, Kung YL, Liu CT & Lii CK (1999) Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets. Nutrition and Cancer 35, 160-166.
44. Shimokawa H & Vanhoutte PM (1989) Dietary omega-3 fatty acids and endothelium-depedent relaxations in porcine coronary arteries. American Journal of Physiology 256, H968-H973.
45. Sparnins VL, Barany G & Watenberg LW (1988) Effects of organosulfur compounds from garlic and onions on benzo[a]-pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 9, 131-134.
46. Su GM, Sefton RM & Murray M (1999) Down-regulation of rat hepatic microsomal P-450 in microvesicular steatosis induced by orotic acid. Journal of Pharmacology and Experimental Therapeutics 291, 953-959.
47. Tsai CF, Lii CK, Yang JJ, Liu K, Lin WL & Chen HW (2001) Prostaglandin E2 is involved in the increase of cytochrome P-450 2B1 expression by alpha-tocopheryl succinate in primary rat hepatocytes in the presence of phenobarbital. Nutrition and Cancer 41, 188-195.
48. 1 mice. Lipids 29, 561-568.
49. Vos RM & Van Bladeren PJ (1990) Glutathione S-transferases in relation to their role in the biotransformation of xenobiotics. Chemico-Biological Interactions 75, 241-265.
50. Waxman DJ (1999) P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR. Archives of Biochemistry and Biophysics 369, 11-23.
51. Yang CS, Smith TJ & Hong JY (1994) Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: Opportunities and limitations. Cancer Research 54, 1982s-1986s.