Induction chemotherapy with gemcitabine and oxaliplatin for locally advanced cervical carcinoma

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 26, Issue 1, 2003, Pages 22-25

  Dueñas González, Alfonso ^a,b   López Graniel, Carlos ^a   González, Aaron ^a   Gomez, Ernesto ^a   Rivera, Lesbia ^a   Mohar, Alejandro ^a   Chanona, Gregorio ^a   Trejo Becerril, Catalina ^a   De La Garza, Jaime ^a  

^a INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Cervical cancer; Gemcitabine; Neoadjuvant chemotherapy; Oxaliplatin

Indexed keywords

GEMCITABINE; OXALIPLATIN;

ADULT; ALOPECIA; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DRUG ACTIVITY; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; EXTRAPYRAMIDAL SYNDROME; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; GRANULOCYTOPENIA; HUMAN; LEUKOPENIA; MOUTH DISEASE; NAUSEA; NEPHROTOXICITY; NEUROTOXICITY; NEUTROPENIA; PHARYNX DISEASE; PILOT STUDY; SKIN TOXICITY; THROMBOCYTOPENIA; TOXICITY; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA; VOMITING;

ADENOCARCINOMA; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM STAGING; ORGANOPLATINUM COMPOUNDS; UTERINE CERVICAL NEOPLASMS;

EID: 0037320561     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-200302000-00005     Document Type: Article

References (20)

1. Mohar A, Frias-Mendivil M. Epidemiology of cervical cancer. Cancer Invest 2000;18:584-90.
2. Lehman M, Thomas G. Is concurrent chemotherapy and radiotherapy the new standard of care for locally advanced cervical cancer? Int J Gynecol Cancer 2001;11:87-99.
3. Tierney JF, Stewart LA, Parmar MK. Can the published data tell us about the effectiveness of neoadjuvant chemotherapy for locally advanced cancer of the uterine cervix? Eur J Cancer 1999;35:406-9.
4. Eddy GL. Neoadjuvant chemotherapy before surgery in cervical cancer. Monogr NCI 1996;21:93-6.
5. Sardi J, Giaroli A, Sananes C, et al. Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: the final results. Gynecol Oncol 1997;67:61-9.
6. Benedetti-Panici P, Landoni F, Greggi S, et al. Neoadjuvant chemotherapy and radical surgery vs exclusive radiotherapy in locally advanced squamous cell cervical cancer. Results from the Italian Multicenter Randomized Trial. Proc Am Soc Clin Oncol 1999;18:357a.
7. Sardi J, Giaroli A, Sananes C, et al. Randomized trial with neoadjuvant chemotherapy in stage IIIB squamous carcinoma of the cervix uteri: an unexpected therapeutic management. Int J Gynecol Cancer 1996;6:85-93.
8. Hui YF, Reitz J. Gemcitabine. A cytidine analogue active against solid tumors. Am J Health Syst Pharm 1997;54:162-70.
9. Lawrence TS, Eisbruch A, McGinn CJ, et al. Radiosensitization by gemcitabine. Oncology (Huntingt) 1999;13(suppl 5):1355-60.
10. Hernández P, Olivera P, Dueñas-Gonzalez A, et al. Gemcitabine activity in cervical cancer cell lines. Cancer Chemother Pharmacol 2001;48:488-92.
11. Dueñas-González A, Hinojosa-Garcia LM, López-Graniel C, et al. Weekly cisplatin/low-dose gemcitabine combination for advanced and recurrent cervical carcinoma. Am J Clin Oncol 2001;24:201-3.
12. Dueñas-González A, López-Graniel C, González A, et al. A phase II study of gemcitabine and cisplatin combination as induction chemotherapy for untreated locally advanced cervical carcinoma. Ann Oncol 2001;12:541-7.
13. Faivre S, Raymond E, Woynarowski JM, et al. Supraadditive effect of 2′,2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer Chemother Pharmacol 1999;44:117-23.
14. Mavroudis D, Kourousis C, Kakolyris S, et al. Phase I study of the gemcitabine/oxaliplatin combination in patients with advanced solid tumors: a preliminary report. Semin Oncol 2000;27(suppl 2):25-30.
15. Sugiyama T, Nishida T, Kumagai S, et al. Combination therapy with irinotecan and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer. Br J Cancer 1999;81:95-8.
16. Pignata S, Silvestro G, Ferrari E, et al. Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. J Clin Oncol 1999;17:756-60.
17. Zanetta G, Lissoni A, Pellegrino A, et al. Neoadjuvant chemotherapy with cisplatin, ifosfamide and paclitaxel for locally advanced squamous-cell cervical cancer. Ann Oncol 1998;9:977-80.
18. Goff BA, Muntz HG, Paley PJ, et al. Impact of surgical staging in women with locally advanced cervical cancer. Gynecol Oncol 1999;74:436-42.
19. Grigsby PW, Siegel BA, Dehdashti F. Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol 2001;19:3745-9.
20. Dueñas-Gonzalez A, Rivera L, Mota A, et al. The advantages of concurrent chemoradiation after induction neoadjuvant chemotherapy for locally advanced cervical carcinoma. Arch Med Res 2002;33:201-2.