Impact of intraoperative radiation on postoperative and disease-specific outcome after pancreatoduodenectomy for adenocarcinoma: A propensity score analysis

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 26, Issue 1, 2003, Pages 16-21

  Schwarz, Roderich E ^a,c   Smith, David D ^b   Keny, Hemant ^a   Iklé, David N ^b   Shibata, Stephen I ^b   Chu, David Z J ^a   Pezner, Richard D ^b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Biostatistics ^*  (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Intraoperative radiation; Pancreatic cancer; Periampullary adenocarcinoma; Postoperative complications; Propensity score analysis

Indexed keywords

FLUOROURACIL; GEMCITABINE;

ADULT; AGED; ARTICLE; BEAM THERAPY; BILE DUCT CARCINOMA; BLEEDING; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; DUODENUM CARCINOMA; FEMALE; HOSPITALIZATION; HUMAN; INFECTION; INTRAOPERATIVE PERIOD; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIMODALITY CANCER THERAPY; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PANCREATICODUODENECTOMY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; RADIATION DOSE; RADIATION HAZARD; SCORING SYSTEM; SURVIVAL RATE; TREATMENT OUTCOME; VATER PAPILLA CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; AMPULLA OF VATER; BILE DUCT NEOPLASMS; DUODENAL NEOPLASMS; FEMALE; HUMANS; INTRAOPERATIVE PERIOD; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0037320560     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-200302000-00004     Document Type: Article

References (40)

1. Greenlee RT, Murray T, Bolden S, et al. Cancer statistics, 2000. CA Cancer J Clin 2000;50:7-33.
2. Fong Y, Blumgart LH, Lin E, et al. Outcome of treatment for distal bile duct cancer. Br J Surg 1996;83:1712-5.
3. Howe JR, Klimstra DS, Moccia RD, et al. Factors predictive of survival in ampullary carcinoma. Ann Surg 1998;228:87-94.
4. Rose DM, Hochwald SN, Klimstra DS, et al. Primary duodenal adenocarcinoma: a ten-year experience with 79 patients [see comments]. J Am Coll Surg 1996;183:89-96.
5. Yeo CJ, Sohn TA, Cameron JL, et al. Periampullary adenocarcinoma: analysis of 5-year survivors. Ann Surg 1998;227:821-31.
6. Evans DB, Abbruzzese JL, Rich TA. Cancer of the pancreas. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology, 5th ed. Philadelphia: Lippincott-Raven, 1997:1054-86.
7. Griffin JF, Smalley SR, Jewell W, et al. Patterns of failure after curative resection of pancreatic carcinoma. Cancer 1990;66:56-61.
8. Abe M, Takahashi M, Yabumoto E, et al. Clinical experiences with intraoperative radiotherapy of locally advanced cancers. Cancer 1980;45:40-8.
9. Sindelar WF, Kinsella TJ. Studies of intraoperative radiotherapy in carcinoma of the pancreas. Ann Oncol 1999;4:226-30.
10. Alfieri S, Morganti AG, Di Giorgio A, et al. Improved survival and local control after intraoperative radiation therapy and postoperative radiotherapy: a multivariate analysis of 46 patients undergoing surgery for pancreatic head cancer. Arch Surg 2001;136:343-7.
11. D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 1998;17:2265-81.
12. Fleming ID, Cooper JS, Henson DE, et al. American Joint Committee on Cancer staging manual. 5th ed. Philadelphia: Lippincott-Raven, 1997.
13. Schwarz RE, Karpeh MS, Brennan MF. Factors predicting hospitalization after operative treatment for gastric carcinoma in patients older than 70 years [see comments]. J Am Coll Surg 1997;184:9-15.
14. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Am Stat Assoc J 1958;53:457-81.
15. Peto R, Pike MC. Conservatism in the approximation E(0-E)2/E in the log rank test for survival data or tumor incidence data. Biometrics 1973;29:579-84.
16. Cox DR. Regression models and life tables. J R Stat Assoc 1972;29:187-220.
17. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika 1983;70:41-55.
18. Nishimura Y, Hosotani R, Shibamoto Y, et al. External and intraoperative radiotherapy for resectable and unresectable pancreatic cancer: analysis of survival rates and complications. Int J Radiat Oncol Biol Phys 1997;39:39-49.
19. Roldan GE, Gunderson LL, Nagorney DM, et al. External beam versus intraoperative and external beam irradiation for locally advanced pancreatic cancer. Cancer 1988;61:1110-6.
20. Mohiuddin M, Regine WF, Stevens J, et al. Combined intraoperative radiation and perioperative chemotherapy for unresectable cancers of the pancreas. J Clin Oncol 1995;13:2764-8.
21. Shipley WU, Wood WC, Tepper JE, et al. Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann Surg 1984;200:289-96.
22. Shibamoto Y, Nishimura U, Abe M. Intraoperative radiotherapy and hyperthermia for unresectable pancreatic cancer. Hepatogastroenterology 1996;43:326-32.
23. Kawamura M, Kataoka M, Fujii T, et al. Electron beam intraoperative radiation therapy (EBIORT) for localized pancreatic carcinoma. Int J Radiat Oncol Biol Phys 1992;23:751-7.
24. Dobelbower RR, Merrick HW, Khuder S, et al. Adjuvant radiation therapy for pancreatic cancer: a 15-year experience. Int J Radiat Oncol Biol Phys 1997;39:31-7.
25. Hosotani R, Kogire M, Arii S, et al. Results of pancreatectomy with radiation therapy for pancreatic cancer. Hepatogastroenterology 1997;44:1528-35.
26. Farrell TJ, Barbot DJ, Rosato FE. Pancreatic resection combined with intraoperative radiation therapy for pancreatic cancer. Ann Surg 1997;226:66-9.
27. Reni M, Panucci MG, Ferreri AJ, et al. Effect on local control and survival of electron beam intraoperative irradiation for resectable pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys 2001; 50:651-8.
28. Hiraoka T, Uchino R, Kanemitsu K, et al. Combination of intraoperative radiation with resection of cancer of the pancreas. Int J Pancreatol 1990;7:201-7.
29. Coquard R, Ayzac L, Gilly FN, et al. Intraoperative radiotherapy in resected pancreatic cancer: feasibility and results. Radiother Oncol 1997;44:271-5.
30. Kokubo M, Nishimura Y, Shibamoto Y, et al. Analysis of the clinical benefit of intraoperative radiotherapy in patients undergoing macroscopically curative resection for pancreatic cancer. Int J Radiat Oncol Biol Phys 2000;48:1081-7.
31. Ouchi K, Sugawara T, Ono H, et al. Palliative operation for cancer of the head of the pancreas: significance of pancreaticoduodenectomy and intraoperative radiation therapy for survival and quality of life [see comments]. World J Surg 1998;22:413-6.
32. Joffe MM, Rosenbaum PR. Invited commentary: propensity scores. Am J Epidemiol 1999;150:327-33.
33. Chakravarthy A, Abrams RA, Yeo CJ, et al. Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. Int J Radiat Oncol Biol Phys 2000;48:1089-96.
34. Merchant NB, Conlon KC, Saigo P, et al. Positive peritoneal cytology predicts unresectability of pancreatic adenocarcinoma. J Am Coll Surg 1999;188:421-6.
35. Willett CG, Lewandrowski K, Warshaw AL, et al. Resection margins in carcinoma of the head of the pancreas. Implications for radiation therapy. Ann Surg 1993;217:144-8.
36. Evans DB, Termuhlen PM, Byrd DR, et al. Intraoperative radiation therapy following pancreaticoduodenectomy. Ann Surg 1993;218:54-60.
37. Balcom JHt, Rattner DW, Warshaw AL, et al. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg 2001; 136:391-8.
38. Pisters PW, Abbruzzese JL, Janjan NA, et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol 1998;16:3843-50.
39. Yamaguchi K, Nakamura K, Kimura M, et al. Intraoperative radiation enhances decline of pancreatic exocrine function after pancreatic head resection. Dig Dis Sci 2000;45:1084-90.
40. Staley CA, Lee JE, Cleary KR, et al. Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am J Surg 1996;171:118-4.