Dietary rhubarb (Rheum rhaponticum) stalk fibre does not lower plasma cholesterol levels in diabetic rats

British Journal of Nutrition

Volumn 89, Issue 2, 2003, Pages 201-206

  Cheema, Sukhinder Kaur ^a,b   Goel, Vinti ^a   Basu, Tapan K ^a   Agellon, Luis B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cholesterol 7 hydroxylase; Diabetes; Rhubarb (Rheum rhapontioum) stalk fibre

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; MESSENGER RNA; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; DIET THERAPY; DIETARY FIBER; ENZYME ACTIVITY; ENZYME REGULATION; HOST SUSCEPTIBILITY; LIPID DEGRADATION; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; RHUBARB; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BILE ACIDS AND SALTS; CELLULOSE; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FIBER; LIVER; MALE; MICROSOMES, LIVER; MODELS, ANIMAL; PLANT STEMS; RATS; RATS, INBRED BB; RATS, SPRAGUE-DAWLEY; RHEUM; RNA, MESSENGER; TRIGLYCERIDES;

ANIMALIA; RHEUM; RHEUM RHAPONTICUM; RHEUM X CULTORUM;

EID: 0037319719     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2002768     Document Type: Article

References (32)

1. Abbey M, Triantafilidis C & Toppings DL (1993) Dietary non-starch polysaccharide interact with cholesterol and fish oil in their effects on plasma lipids and hepatic lipoprotein receptor activity in rats. Journal of Nutrition 123, 900-908.
2. Agellon LB (1997) Partial transfection of liver with a synthetic cholesterol 7α-hydroxylase transgene is sufficient to stimulate the reduction of cholesterol in the plasma of hypercholesterolemic mice. Biochemistry and Cell Biology 75, 255-262.
3. Agellon LB & Torchia EC (2000) Intracellular transport of bile acids. Biochimica et Biophysica Acta 1486, 198-209.
4. Basu TK, Ooraikul B & Garg M (1993) The lipid lowering effects of rhubarb stalk fibre: A new source of dietary fibre. Nutrition Research 13, 1017-1024.
5. Bennion LJ & Grundy SM (1977) Effects of diabetes mellitus on cholesterol metabolism in man. New England Journal of Medicine 296, 1365-1371.
6. Brown WV (1994) Lipoprotein disorders in diabetes mellitus. Medical Clinics of North America 78, 143-161.
7. Cheema SK, Cikaluk D & Agellon LB (1997) Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7α-hydroxylase gene expression. Journal of Lipid Research 38, 315-323.
8. Chomczynski P & Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162, 156-158.
9. Feingold KR, Wilson DE, Wood LC, Kwong LK, Moser AH & Grunfield C (1994) Diabetes increases hepatic hydroxymethyl glutaryl coenzyme A reductase protein and mRNA levels in the small intestine. Metabolism 43, 450-454.
10. Fernandez ML (1995) Distinct mechanisms of plasma LDL lowering by dietary fibre in the guinea pig: Specific effects of pectin, guar gum and psyllium. Journal of Lipid Research 36, 2394-2404.
11. Fernandez ML, Lin EC, Trejo A & McNamara DJ (1992) Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pig. Journal of Nutrition 122, 2330-2340.
12. Gallaher DD, Hassel CA, Lee KJ & Gallaher CM (1993) Viscosity and fermentability as attributes of dietary fibre responsible for hypocholesterolemic effect in hamsters. Journal of Nutrition 123, 244-252.
13. Goel V, Cheema SK, Agellon LB, Ooraikul B & Basu TK (1999) Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7-α-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. British Journal of Nutrition 81, 65-71.
14. Goel V, Cheema SK, Agellon LB, Ooraikul B, McBurney MI & Basu TK (1998) In vitro binding of bile salt to rhubarb stalk powder. Nutrition Research 18, 893-903.
15. Goel V, Ooraikul B & Basu TK (1997) Cholesterol lowering effects of rhubarb fibre in hypercholesterolemic men. Journal of American College of Nutrition 16, 600-604.
16. Gonzalez J & Fevery J (1992) Spontaneously diabetic biobreeding rats and impairment of bile acid-independent bile flow and increased biliary bilirubin, calcium and lipid section. Hepatology 16, 426-432.
17. Hansson R (1989) Effect of diabetes, starvation, ethanol and isoniazid on rat liver microsomal 12α-hydroxylase activity involved in bile acid biosynthesis. Biochemical Pharmacology 38, 3386-3389.
18. Horton JD, Cuthbert JA & Spady DK (1994) Regulation of hepatic 7α-hydroxylase expression by dietary psyllium in the hamster. Journal of Clinical Investigation 93, 2084-2092.
19. Kessler II (1971) Mortality experience of diabetic patients: A twenty-six year follow-up study. American Journal of Medicine 51, 715-724.
20. Kimura K, Ogura M (1988) Increased rate of cholic acid formation from 3 alpha, 7 alpha-dihydroxy-5 beta-cholestane in perfused livers from diabetic rats. Biochimica et Biophysica Acta 963, 329-332.
21. Kimura K, Ogura Y & Ogura M (1992) Biosynthesis of cholic acid accelerated by diabetes: Its mechanism and effect of vanadate administration. Biochimica et Biophysica Acta 1123, 303-308.
22. Nakayama H & Nakagawa S (1977) Influence of streptozotocin diabetes on intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the rat. Diabetes 26, 439-444.
23. National Research Council (1995) Nutrient Requirements of Laboratory Animals, 4th Revised ed., pp. 11-79. Washington, DC: The National Academic Press.
24. Nervi FO, Severin CH & Valdivieso VD (1978) Bile acid pool changes and regulation of cholate synthesis in experimental diabetes. Biochimica et Biophysica Acta 529, 212-223.
25. Steel RGD & Torrie JH (1980) Principles and Procedures of Statistics: A Biometrical Approach, pp. 67-119. New York: McGraw-Hill.
26. Subbiah MTR & Yunker RL (1984) Cholesterol 7α-hydroxylase of rat liver: An insulin sensitive enzyme. Biochemical and Biophysical Research Communications 124, 896-902.
27. Torchia EC, Cheema SK & Agellon LB (1996) Coordinate regulation of bile acid biosynthetic and recovery pathways. Biochemical and Biophysical Research Communications 255, 128-133.
28. Turrill EL, McCarron MM & Mikkelson WP (1961) Gallstone and diabetes, ominous association. American Journal of Surgery 102, 184-190.
29. Twisk J, Hoekman FM, Lehman EM, Meijer P, Mager WH & Princen HMG (1995) Insulin suppresses bile acid synthesis in cultured hepatocytes by down regulation of cholesterol 7α-hydroxylate and sterol 27-hydroxylase gene transcription. Hepatology 21, 501-510.
30. Uchida K, Takase H, Kadowaki M, Nomura Y, Matsubara T & Takeuchi N (1979) Altered bile acid metabolism in alloxan diabetic rats. Japanese Journal of Pharmacology 29, 553-562.
31. Yokode M, Hammer RE, Ishibashi S, Brown MS & Goldstein JL (1990) Diet induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors. Science 250, 1273-1275.
32. Young NL, Saudek CD & Crawford SA (1982) Total hydroxy-methylglutaryl CoA reductase activity in the small intestine and liver of insulin-deficient rats. Journal of Lipid Research 23, 266-275.