Use of threshold serum and milk ketone concentrations to identify risk for ketosis and endometritis in high-yielding dairy cows

American Journal of Veterinary Research

Volumn 64, Issue 2, 2003, Pages 188-194

  Reist, Martin ^a,b,c   Erdin, Daniel K ^a,d   von Euw, Daniel ^a,e   Tschümperlin, Kaspar M ^a   Leuenberger, Hans ^a   Hammon, Harald M ^b   Künzi, Niklaus ^a   Blum, Jürg W ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Novartis Ctr Recher Sante Anim SA   (Switzerland)

^d Swiss Farming Association   (Switzerland)

^e Ministry of Agriculture   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETONE; FATTY ACID; GLUCOSE; INSULIN; KETONE DERIVATIVE; LACTOSE; LEPTIN; MILK FAT; MILK PROTEIN; SOMATOMEDIN C;

ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DAIRY CATTLE; DELIVERY; DIAGNOSTIC VALUE; ENDOMETRITIS; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; KETOACIDOSIS; METABOLIC ACIDOSIS; MILK LEVEL; MILK PRODUCTION; MILK YIELD; NONHUMAN; PROTEIN BLOOD LEVEL; PUERPERIUM; RISK ASSESSMENT;

3-HYDROXYBUTYRIC ACID; ACETONE; ANIMAL FEED; ANIMAL HUSBANDRY; ANIMALS; CATTLE; DAIRYING; ENDOMETRIOSIS; FEMALE; KETONES; KETOSIS; MILK; ODDS RATIO; RISK FACTORS;

ANIMALIA; BOS TAURUS;

EID: 0037317270     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2003.64.188     Document Type: Article

References (45)

1. Krebs HA. Bovine ketosis. Vet Rec 1966;78:187-192.
2. Baird GD, Hibbit KG, Hunter GD, et al. Biochemical aspects of bovine ketosis. Biochem J 1968;107:683-689.
3. Baird GD. Primary ketosis in the high-producing dairy cow: clinical and subclinical disorders, treatment, prevention, and outlook. J Dairy Sci 1982;65:1-10.
4. Blum JW, Jans F, Moses W, et al. Twenty-four-hour pattern of blood hormone and metabolite concentrations in high-yielding dairy cows: effects of low or high amounts of starch, or crystalline fat. Zentralbl Veterinarmed [A] 1985;32:401-418.
5. Gustafsson AH, Emanuelson U. Milk acetone concentration as an indicator of hyperketonaemia in dairy cows: the critical value revised. Anim Sci 1996;63:183-188.
6. Chilliard Y, Bocquier F, Doreau M. Digestive and metabolic adaptations of ruminants to undernutrition, and consequences on reproduction. Reprod Nutr Dev 1998;38:131-152.
7. Miettinen PV. Relationship between milk acetone and milk yield in individual cows. Zentralbl Veterinarmed [A] 1994;41:102-109.
8. Dohoo IR, Martin SW. Subclinical ketosis: prevalence and associations with production and disease. Can J Comp Med 1984;48:1-5.
9. Fourichon C, Seegers H, Bareille N, et al. Effects of disease on milk production in the dairy cow: a review. Prev Vet Med 1999;41:1-35.
10. Reist M, Koller A, Busato A, et al. First ovulation and ketone body status in the early postpartum period of dairy cows. Theriogenology 2000;54:685-701.
11. Veenhuizen JJ, Drackley JK, Richard MJ, et al. Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. J Dairy Sci 1991;74:4238-4253.
12. Arrigo Y, Chaubert C, Daccord R, et al. Eidgenössische Forschungsanstalt für Nutztiere. In: Fütterungsempfehlungen und Nährwerttabellen für Wiederkäuer. 4th ed. Zollikofen, Switzerland: Landwirtschaftliche Lehrmittelzentrale, 1999.
13. Edmonson AJ, Lean IJ, Weaver LD, et al. A body condition scoring chart for Holstein dairy cows. J Dairy Sci 1989;72:68-78.
14. Bruckmaier RM, Gregoretti L, Jans F, et al. Longissimus dorsi muscle diameter, backfat thickness, body condition scores and skinfold values related to metabolic and endocrine traits in lactating dairy cows fed crystalline fat or free fatty acids. Zentralbl Veterinarmed [A] 1998;45:397-410.
15. Schwager-Suter R, Stricker C, Erdin D, et al. Relationship between body condition scores and ultrasound measurements of subcutaneous fat and m. longissimus dorsi in dairy cows differing in size and type. Anim Sci 2000;71:465-470.
16. Aeberhard K, Bruckmaier RM, Blum JW. Metabolic, enzymatic and endocrine status in high-yielding dairy cows-part 2. Zentralbl Veterinarmed [A] 2001;48:111-127.
17. Delavaud C, Bocquier F, Chilliard Y, et al. Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. J Endocrinol 2000;165:519-526.
18. Marstorp P, Anfält T, Andersson L. Determination of oxidized ketone bodies in milk by flow injection analysis. Anal Chim Acta 1983;149:281-289.
19. Aeberhard K, Bruckmaier RM, Kuepfer U, et al. Milk yield and composition, nutrition, body conformation traits, body condition scores, fertility and diseases in high-yielding dairy cows-part 1. Zentralbl Veterinarmed [A] 2001;48:97-110.
20. Hosmer DW, Lemeshow S. Applied logistic regression. New York: John Wiley & Sons, 1989.
21. Andersson L, Emanuelson U. An epidemiological study of hyperketonaemia in Swedish dairy cows; determinants and the relation to fertility. Prev Vet Med 1985;3:449-462.
22. Ronge H, Blum JW, Clément F, et al. Somatomedin C in dairy cows related to energy and protein supply and to milk production. Anim Prod 1988;47:165-183.
23. Eicher R, Liesegang A, Bouchard E, et al. Effect of cow-specific factors and feeding frequency of concentrate on diurnal variations of blood metabolites in dairy cows. Am J Vet Res 1999;60:1493-1499.
24. Blum JW, Bruckmaier RM, Vacher PY, et al. Twenty-four-hour patterns of hormones and metabolites in week 9 and 19 of lactation in high-yielding dairy cows fed triglycerides and free fatty acids. Zentralbl Veterinarmed [A] 2000;47:43-60.
25. Steen A, Osteras O, Gronstol H. Evaluation of additional acetone and urea analyses, and of the fat-lactose-quotient in cow milk samples in the herd recording system in Norway. Zentralbl Veterinarmed [A] 1996;43:181-191.
26. Miettinen PV, Setala JJ. Relationship between subclinical ketosis, milk production and fertility in Finnish dairy cattle. Prev Vet Med 1993;17:1-8.
27. Ostergaard S, Gröhn YT. Effects of diseases on test day milk yield and body weight of dairy cows from Danish research herds. J Dairy Sci 1999;82:1188-1201.
28. Rajala-Schultz PJ, Gröhn YT, McCulloch CE. Effects of milk fever, ketosis, and lameness on milk yield in dairy cows. J Dairy Sci 1999;82:288-294.
29. Miller HV, Kimsey PB, Kendrick JW. Endometritis of dairy cattle: diagnosis, treatment, and fertility Bov Pract 1980;15:13-23.
30. De Kruif A, Gunnink JW, De Bois CH. Onderzoek en behandeling van endometritis post partum bij het rund. Tijdschr Diergeneesk 1982;107:717-725.
31. Markusfeld O. Factors responsible for post parturient metritis in dairy cattle. Vet Rec 1984;114:539-542.
32. Markusfeld O. Relationship between overfeeding, metritis and ketosis in high yielding dairy cows. Vet Rec 1985;116:489-491.
33. Klucinski W, Degorski A, Miernik-Degorska E, et al. Effect of ketone bodies on the phagocytic activity of bovine milk macrophages and polymorphonuclear leukocytes. Zentralbl Veterinarmed [A] 1988;35:632-639.
34. Suriyasathaporn W, Daemen AJ, Noordhuizen-Stassen EN, et al. Beta-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes. Vet Immunol Immunopathol 1999;68:177-186.
35. Markusfeld O. Periparturient traits in seven high dairy herds. Incidence rates, association with parity, and interrelationships among traits. J Dairy Sci 1987;70:158-166.
36. Emanuelson U, Oltenacu PA, Gröhn YT. Nonlinear mixed model analyses of five production disorders of dairy cattle. J Dairy Sci 1993;76:2765-2772.
37. Grohn YT, Erb HN, McCulloch CE, et al. Epidemiology of metabolic disorders in dairy cattle: association among host characteristics, disease, and production. J Dairy Sci 1989;72:1876-1885.
38. Oltenacu PA, Ekesho I. Epidemiological study of clinical mastitis in dairy cattle. Vet Res 1994;25:208-212.
39. Suriyasathaporn W, Heuer C, Noordhuizen-Stassen EN, et al. Hyperketonemia and the impairment of udder defense: a review. Vet Res 2000;31:397-412.
40. Kunz PL, Blum JW, Hart IC, et al. Effects of different energy intakes before and after calving on food intake, performance and blood hormones and metabolites in dairy cows. Anim Prod 1985;40:219-231.
41. Busato A, Faissler D, Küpfer U, et al. Body condition scores in dairy cows: associations with metabolic and endocrine changes. Zentralbl Veterinarmed [A] 2002 (in press).
42. Heuer C, Schukken YH, Dobbelaar P. Postpartum body condition score and results from the first test day milk as predictors of disease, fertility, yield, and culling in commercial dairy herds. J Dairy Sci 1999;82:295-304.
43. Holtenius P, Holtenius K. New aspects of ketone bodies in energy metabolism of dairy cows: a review. Zentralbl Veterinarmed [A] 1996;43:579-587.
44. Botts RL, Hemken RW, Bull LS. Protein reserves in the lactating dairy cow. J Dairy Sci 1979;62:433-440.
45. Drackley JK, Overton TR, Neil Douglay G. Adaptations of glucose and long-chain fatty acid metabolism in the liver of dairy cows during the periparturient period. J Dairy Sci 2001;84(suppl):E100-E112.