Zinc in pig nutrition: The essential trace element and potential adverse effect on environment;Le zinc dans l'alimentation du porc: Oligo-élément essentiel et risque potentiel pour l'environnement

Productions Animales

Volumn 16, Issue 1, 2003, Pages 3-18

  Revy, P S ^a,b   Jondreville, C ^a   Dourmad, J Y ^a   Nys, Y ^c  

^a CEMAGREF   (France)

^b ZI de la Gare ^*  (France)

^c STATION DE RECHERCHES AVICOLES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SUS SCROFA;

EID: 0037312329     PISSN: 09900632     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Adeola O., 1995. Digestive utilization of minerals by weanling pigs fed copper- and phytase-supplemented diets. Can. J. Anim. Sci., 75, 603-610.
2. Adeola O., Lawrence B.V., Sutton A.L., Cline T.R., 1995. Phytase-induced changes in mineral utilization in zinc-supplemented diets for pigs. J. Anim. Sci., 73, 3384-3391.
3. AFRC (Agricultural and Food Research Council), 1990. AFRC Technical Committee on Responses to Nutrients, Report Number 4, Nutrient requirements of sows and boars. Nutr. Abstr. a. Rev. (Series B) 60, 383-406.
4. Aggett P.J., 1991. The assessment of zinc status: a personal view. Proc. Nutr. Soc., 50, 9-17.
5. Ammerman C.B., Henry P.R., Miles R.D., 1998. Supplemental organically-bound mineral compounds in livestock nutrition. In: P.C. Garnsworthy and J. Wiseman (eds), Recent Advances in Animal Nutrition, Nottingham University Press.
6. ARC (Agricultural Research Council), 1981. The Nutrient Requirements of Pigs. Commonwealth Agricultural Bureaux, Slough UK.
7. Ashida K.Y., Tamura A., Matsui T., Yano H., Nakajima T., 1999. Effect of dietary microbial phytase on zinc bioavailability in growing pigs. Anim. Sci. J., 70, 306-311.
8. Bertrand G., Bhattacherjee R.C., 1935. Recherches sur l'action combinée du zinc et des vitamines dans l'alimentation des animaux. Ann. Inst. Pasteur, 55, 265-272.
9. Biehl R.R., Baker D.H., DeLuca H.F., 1995. 1 a-hydroxylated cholecalciferol compounds act additively with microbial phytase to improve phosphorus, zinc and manganese utilization in chicks fed soy-based diets. J. Nutr., 125, 2407-2416.
10. Buckley W.T., 2000. Trace elements dynamics. In: J.P.F. D'Mello (eds), Farm Animal Metabolism and Nutrition, CABI Publishing, Edinburgh, UK, 161-182.
11. Carlson M.S., Hill G.M., Link J.E., 1999. Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations. J. Anim. Sci., 77, 1199-1207.
12. Chappuis P., 1991. Les oligo-éléments en nutrition et en thérapeutique. Lavoisier, Tee & Doc, 643 pp.
13. Chappuis P., Favier A., 1995. Les oligo-éléments en médecine et en biologie. Lavoisier, Tec & Doc, Paris, 474 p.
14. Cheng J., Kornegay E.T., Schell T.C., 1998. Influence of dietary lysine on the utilisation of zinc from zinc sulfate and a zinc-lysine complex by young pigs. J. Anim. Sci., 76, 1064-1074.
15. Chesters J.K., 1992. Trace element-gene interactions. Nutr. Rev., 50, 217-223.
16. Chesters J.K., 1997. Zinc. In: O'Dell B.L. and Sunde R.A. (eds), Handbook of Nutritionally Essential Mineral Elements, Marcel Dekker, New York, 185-230.
17. Coppenet M., Golven J., Simon J.C., Le Roy M., 1993. Evolution chimique des sols en exploitations d'élevage intensif: exemple du Finistère. Agronomie, 13, 77-83.
18. CORPEN, 1996. Estimation des rejets d'azote et de phosphore des élevages de porcs. Impact des modifications de conduite alimentaire et des performances techniques. Comité d'Orientation pour la Réduction de la pollution des Eaux par les Nitrates, les phosphates et les produits phyto-sanitaires provenant des activités agricoles. République Française, Ministère de l'Agriculture de la Pêche et de l'Alimentation, Ministère de l'Environnement, 23 p.
19. Cousins R.J., 1985. Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev., 65, 238-309.
20. Cousins R.J., 1996. Zinc. In: Filer L.J. and Ziegler E.E. (eds), Present knowledge in nutrition, 7th edition, Washington, 29, 293-307.
21. Cousins R.J., McMahon R.J., 2000. Integrative aspects of zinc transporters. J. Nutr., 130 (Suppl.), 1384S-1387S.
22. Cox D.H., Hale O.M., 1977. Liver iron depletion without copper loss in swine fed excess zinc. J. Nutr, 77, 225-228.
23. Davies N.T., Nightingale R., 1975. The effects of phytate on intestinal absorption and secretion of zinc, and whole body retention of zinc, copper, iron and manganese in rats. Br. J. Nutr., 34, 243-258.
24. Davies N.T., Olpin S.E., 1979. Studies on the phytate:zinc molar contents in diets as a determinant of Zn availability to young rats. Br. J. Nutr, 41, 590-603.
25. Dourmad J.Y., Pomar C., Massé D., 2002. Modélisation du flux de composés à risque pour l'environnement dans un élevage porcin. Journées Rech. Porcine en France, 34, 183-194.
26. Edwards H.M.III, Baker D.H., 1999. Bioavailability of zinc in several sources of zinc oxide, zinc sulfate, and zinc metal. J. Anim. Sci., 77, 2730-2735.
27. Fordyce E.J., Forbes R.M., Robbins K.R., Erdman J.W., 1987. Phytate ¥ Calcium/Zinc molar ratios: Are they predictive of zinc bioavailability, J. Food Sci., 52, 440-444.
28. Fryer A., Miller E.R., Ku P.K., Ullrey D.E., 1992. Effect of elevated dietary zinc on growth performance of weanling swine. Michigan State Univ. Rep. of Swine Res., 520, 128-132.
29. GfE (Gesellschaft für Ernährungsphysiologie), 1987. Ausschuss für Bedarfsnormen. Energie und Nährstoffbedarf landwirtschaftl. Nutztiere, Nr. 4 Schweine, DLG-Verlag Frankfurt/M.
30. Hahn J.D., Baker D.H., 1993. Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. J. Anim. Sci., 71, 3020-3024.
31. Hedges J.D., Kornegay E.T., Thomas H.R., 1976. Comparison of dietary zinc levels for reproducing sows and the effect of dietary zinc and calcium on the subsequent performance of their progeny. J. Anim. Sci., 43, 453-463.
32. Hill G.M., Miller E.R., 1983. Effect of dietary zinc levels on the growth and development of the gilt. J. Anim. Sci., 57, 106-113.
33. nd) chap. 10, CRC Press, Washington, DC, 187-212.
34. Hill G.M., Miller E.R., Stowe H.D., 1983a. Effect of dietary zinc levels on health and productivity of gilts and sows through two parities. J. Anim. Sci., 57, 114-122.
35. Hill G.M., Miller E.R., Ku P.K., 1983b. Effect of dietary zinc levels on mineral concentration in milk. J. Anim. Sci., 57, 123-129.
36. Hill G.M., Miller E.R., Whetter P.A., Ullrey D.E., 1983c. Concentration of minerals in tissues of pigs from dams fed different levels of dietary zinc. J. Anim. Sci., 57, 130-138.
37. Hill D.A., Peo E.R.Jr., Lewis A.J., Crenshaw J.D., 1986. Zinc-amino acid complexes for swine. J. Anim. Sci., 63, 121-130.
38. Hill G.M., Cromwell G.L., Crenshaw T.D., Dove C.R., Ewan R.C., Knabe D.A., Lewis A.J., Libal G.W., Mahan D.C., Shurson G.G., Southern L.L., Veum T.L., 2000. Growth promotion effects and plasma changes from feeding high dietary concentrations of zinc and copper to weanling pigs (regional study). J. Anim. Sci., 78, 1010-1016.
39. Hill G.M., Mahan D.C., Carter S.D., Cromwell G.L., Ewan R.C., Harrold R.L., Lewis A.J., Miller P.S., Shurson G.C., Veum T.L., 2001. Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. J. Anim. Sci., 79, 934-941.
40. Hoekstra W.G., Faltin B.C., Lin C.W., Roberts H.F., Grummer R.H., 1967. Zinc deficiency in reproducing gilts fed a diet high in calcium and its effect on tissue zinc and blood serum alkaline phosphatase. J. Anim. Sci., 26, 1348-1357.
41. Höhler D., Pallauf J., 1993. Effect of citric acid added to a maize-soya-diet with or without Zn-supplementation on the availability of minerals. J. Anim. Physiol. a. Anim. Nutr., 69, 133-142.
42. Höhler D., Pallauf J., 1994. Effects of Zn-supply and addition of citric acid to a maize-soya-diet on the nutritional efficiency and absorption of minerals in piglets. J. Anim. Physiol. a. Anim. Nutr., 71, 189-199.
43. Holm A., 1988. Escherichia coli associated diarrhea in weaner pigs: Zinc oxide added to the feed as a preventive measure. Dan. Veterinaertidsskr., 72, 1118-1126.
44. Hsu F.S., Krook L.P., Pond W.G., Duncan J.R., 1975. Interactions of dietary calcium with toxic levels of lead and zinc in pigs. J. Nutr., 105, 112-118.
45. Hurley L.S., 1981. Teratogenic effects of manganese, zinc and copper in nutrition. Physiol. Rev., 61, 249-295.
46. INRA, 1989. L'alimentation des animaux monogastriques: porcs, lapins, volailles. Institut National de la Recherche Agronomique, Paris, 282 p.
47. INRA-AFZ, 2002. Tables de composition et de valeur nutritive des matières premières destinées aux animaux d'élevage. Porcs, volailles, bovins, ovins, caprins, lapins, chevaux, poissons. D. Sauvant, J.-M. Perez, G. Tran (eds), INRA, Paris, France.
48. Jensen-Waern M., Melin L., Lindberg R., Johannisson A., Peterson L., Wallgren P., 1998. Dietary zinc oxide in weaned pigs: effects on performance, tissue concentrations, morphology, neutrophil functions and faecal microflora. Res. Vet. Sci., 64, 225-231.
49. Jondreville C., Revy P.S., Dourmad J.Y., 2002. Dietary means to better control the environmental impact of copper and zinc in pig feeding. In: Book of Abstracts of the 53rd Annual Meeting of the European Association for Animal Production, Cairo, Egypt, 8, 100.
50. Jongbloed A.W., Mroz Z., van der Weij-Jongbloed R., Kemme P.A., 2000. The effects of microbial phytase, organic acids and their interaction in diets for growing pigs. Livest Prod. Sci., 67, 113-122.
51. JORF, 1998. Arrêté du 8 janvier 1998 fixant les prescriptions techniques applicables aux épandages de boues sur les sols agricoles pris en application de décret no 97-1153 du 8 décembre 1997 relatif à l'épandage des boues issues du traitement des eaux usées. Journal Officiel de la République Française, 31 janvier 1998, 1563-1571.
52. Kalinowski J., Chavez E.R., 1986. Low dietary zinc intake during pregnancy and gestation of gilts. I. Effects on the dam. Can. J. Anim. Sci., 66, 201-216.
53. Katouli M., Melin L., Jensen-Waern M., Wallgren P., Mollby R., 1999. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. J. App. Microbiol., 87, 564-573.
54. Kavanagh N.T., 1992. The effect of feed supplemented with zinc oxide on the performance of recently weaned pigs. Proc. Int. Pig Vet. Meetings, 616. The Hague, Netherlands.
55. King J.C., 1990. Assessment of zinc status. J. Nutr., 120, 1474-1479.
56. Kirchgessner M., Roth EX., 1982. Fumaric acid as a feed additive in pig nutrition. Pig News Inf., 3, 259-264.
57. Kirchgessner M., Spörl R., Roth-Maier D.A., 1980. Fecal excretion and apparent absorption of copper, zinc, nickel and manganese in nonpregnant and pregnant sows with different supplies of trace elements. Z. Tierphysiol. Tierernährg. Futtermittelkd., 44, 98-101.
58. Kirchgessner M., Paulicks B.R., Roth H.P., 1993. Zinc in animal nutrition: function, deficiency, diagnosis, requirement, supply and absorption. Ciencia e Investigacion Agraria, 20, 182-201.
59. Kirchgessner M., Kreuzer M., Roth F.X., 1994. Alters- und geschlechtsbedingte unterschiede in den Gehalte an Fe, Zn, Cu und Mn verschiedener Körperpartien sowie ihre Retention bei Mastschweinen. Arch. Anim. Nutr., 46, 327-337.
60. Kratzer F.H., Vohra P., 1986. Chelates in nutrition. CRC Press, Boca Raton, Florida, 169 p.
61. Krebs N.F., 2000. Overview of zinc absorption and excretion in the human gastrointestinal tract. J. Nutr., 130 (Suppl.), 1374S-1377S.
62. Lantzsch H.J., Wjst S., Drochner W., 1995. The effect of dietary calcium on the efficacy of microbial phytase in rations fror growing pigs. J. Anim. Physiol. a. Anim. Nutr., 73, 19-26.
63. Le Grusse J., Watier B., 1993. Les vitamines: Données biochimiques, nutritionnelles et cliniques. Centre d'Etude et d'Information sur les Vitamines, Produits Roche, France, 304 pp.
64. Lei X.G., Ku P.K., Miller E.R., Ullrey D.E., Yokoyama M.T., 1993. Supplemental microbial phytase improves bioavailability of dietary zinc to weanling pigs. J. Nutr, 123, 1117-1123.
65. Levasseur P., Texier C., 2001. Teneurs en éléments trace métalliques des aliments et des lisiers de porcs à l'engrais, de truies et de porcelets. Journées Rech. Porcine en France, 33, 57-62.
66. L'Herroux L., 1997. Devenir des éléments métalliques provenant des effluents d'élevage apportés aux parcelles agricoles. Etude du modèle expérimental Solepur et cas de l'estuaire de l'Aber Wrach. Thèse doctorat UBO, 211 p.
67. Liptrap D.O., Miller E.R., Ullrey D.E., Whitenack D.L., Schoepke B.L., Luecke R.W, 1970. Sex influence on the zinc requirement of developing swine. J. Anim. Sci., 30, 736-741.
68. Mahan D.C., Newton E.A., 1995., Effect of initial breeding weight on macro- and micromineral composition over a three-parity period using a high-producing sow genotype. J. Anim. Sci., 73, 151-158.
69. Mahan D.C., Shields R.G.Jr., 1998. Macro- and micromineral composition of pigs from birth to 145 kilograms of body weight. J. Anim. Sci., 76, 506-512.
70. Mavromichalis I., Peter C.M., Parr T.M., Ganessunker D., Baker D.H., 2000. Growth-promoting efficacy in young pigs of two sources of zinc oxide having either a high or a low bioavailability of zinc. J. Anim. Sci., 78, 2896-2902.
71. McGrath S.P., Chaudri A.M., Giller K.E., 1995. Long term effects of metals in sewage sludge on soils, microorganisms and plants. J. Ind. Microbiol, 14, 94-104.
72. Mertz W., 1977. Criteria for adequacy and safety of trace elements in animal nutrition. J. Arum. Sci., 44, 469-474.
73. Miller E.R., Luecke R.W., Ullrey D.E., Baltzer B.V., Bradley B.L., Hoefer J.A., 1968. Biochemical, skeletal and allometric changes due to zinc deficiency in the baby pig. J. Nutr., 95, 278-286.
74. Mohanna C., Nys Y., 1999. Changes in zinc and manganese availability in broiler chicks induced by vegetal and microbial phytases. Anim. Feed Sci. Technol., 77, 241-253.
75. Morel J.L., 1997. Bioavaibility of trace elements to terrestrial plants- Chapter 6. In: Tarradellas J., Bitton G., Rossel D. (eds), Soil Ecotoxicology, F1, 141-176. Lewis Publihers, CRC Press, Boca Raton.
76. Mornet P., Tournut J., Toma B., 1982. Le porc et ses maladies. Maloine, Paris, France.
77. Morris E.R., Ellis R., 1980. Effect of dietary phytate/zinc molar ratio on growth and bone zinc response of rats fed semipurified diets. J. Nutr., 110, 1037-1045.
78. NRC, 1998. Nutrient Requirements of Swine (10th Edition). National Academy Press, Washington, DC.
79. Oberleas D., Muhrer M.E., O'Dell B.L., 1962. Effects of phytic acid on zinc availability and parakeratosis in swine. J. Anim. Sci., 21, 57-61
80. Oberleas D., Muhrer M.E., O'Dell B.L., 1966. Dietary metal-complexing agents and zinc availability in the rat. J. Nutr. 90, 56-62.
81. O'Dell B.L., 1984. Bioavalability of trace elements. Nutr. Rew., 42, 301-308.
82. O'Dell B.L., Savage J.E., 1960. Effect of phytic acid on zinc availability. Proc. Soc. Exp. Biol. Med., 103, 304-306.
83. Paboeuf F., Calvar C., Landrain B., Roy H., 2001. Impact de la réduction des niveaux alimentaires en matières azotée totale, en phosphore, en cuivre et en zinc sur les performances et les rejets des porcs charcutiers. Journées Rech. Porcine en France, 33, 49-56.
84. Pallauf J., 1996. Requirements of trace elements for pigs. In: Proc. 47th Annu. Mtg. Eur. Assoc. Anim. Prod., Lillehammer, Norway, 1-8.
85. Pallauf J., Höhler D., Rimbach G., 1992. Effect of microbial phytase supplementation to a maize-soya-diet on the apparent absorption of Mg, Fe, Cu, Mn and Zn and parameters of Zn-status in piglets. J. Anim. Physiol. a. Anim. Nutr., 68, 1-9.
86. Pallauf J., Rimbach G., Pippig S., Schindler B., Most E., 1994a. Effect of phytase supplementation and to aphytate-rich diet based on wheat, barley and soya on the bioavailability of dietary phosphorus, calcium, zinc and protein in piglets. Agribiol. Res., 47, 39-48.
87. Pallauf J., Rimbach G., Pippig S., Schindler B., Höhler D., Most E., 1994b. Dietary effect of phytogenic phytase and an addition of microbial phytase to a diet based on field beans, wheat, peas and barley on the utilization of phosphorus, calcium, magnesium, zinc and protein in piglets. Z. Ernährungswiss., 33, 128-135.
88. Pointillart A., 1994. Phytates, phytases: leur importance dans l'alimentation des monogastriques. INRA Prod. Anim., 7, 29-39.
89. Poulsen H.D., 1989. Zinc oxide for weaned pigs. In: Proc. 40th Annu. Mtg. Eur. Assoc. Anim. Prod., Dublin, Ireland, 8-10.
90. Poulsen H.D., 1995. Zinc oxide for weanling piglets. Acta Agric. Scand., 45, 159-167.
91. Poulsen H.D., 1998. Zinc and copper as feed additives, growth factors or unwanted environmental factors. J. Anim. Feed Sci. 7, 135-142.
92. Poulsen H.D., Larsen T., 1995. Zinc excretion and retention in growing pigs fed increasing levels of zinc oxide. Livest. Prod. Sci., 43, 235-242.
93. Priem R., Maton A., 1980. The influence of the content of trace elements in the feed on the composition of liquid manure of pig. In: Gasser J.K.R (ed), Effluents from livestock, 9-22. Applied Science Publishers, Baking.
94. Raulin J., 1869. Etudes chimiques sur la végétation. Ann. Sci. Natl. Bot. Biol. Végét., 11, 93.
95. Ravindran V., Kornegay E.T., 1993. Acidification of weaner pig diet: A review. J. Sci. Food Agric., 62, 313-322.
96. Roberson K.D., Edwards H.M. Jr., 1994. Effects of 1,25-dihydroxycholecacliferol and phytase on zinc utilization in broiler chicks. Poult. Sci., 73, 1312-1326.
97. Roth F.X., Windisch W., Kirchgessner M., 1998. Mineral metabolism (P, K, Ca, Mg, Zn, Mn, Cu) of piglets supplied with potassium diformate (FormiTM LHS). Agribiol. Res., 51, 177-183.
98. Rucker R.B., Lönnerdal B., Keen C.L., 1994. Intestinal absorption of nutritionally important trace elements. In: Johnson L. R. (ed), Physiology of the gastrointestinal tract, 2183-2202. Raven Press, New York.
99. Schell T.C., Kornegay E.T., 1996. Zinc concentration in tissues and performance of weanling pigs fed pharmacological levels of zinc from ZnO, Zn-methionine, Zn-lysine, or ZnSO4. J. Anim. Sci, 74, 1584-1593.
100. Scott M.L., 1972. Trace Elements in Animal Nutrition. In: Mortverdt JJ, Giordano P.M. and Lindsay W.L. (eds), Micronutrients in Agriculture, Soil Sci. Soc. of Am. Inc. Madison, Wisc., USA, 22, 555-591.
101. Smith W.H., Plumlee M.P., Beeson W.M., 1961. Zinc requirement of the growing pig fed isolated soybean protein semi-purified rations. J. Anim. Sci., 20, 128-132.
102. Smith WH, Plumlee M.P., Beeson W.M., 1962. Effect of source of protein on zinc requirement of the growing pig. J. Anim. Sci., 21, 399-405.
103. Stevenson J.W., Earle I.P., 1956. Studies on parakeratosis in swine. J. Anim. Sci., 15, 1036-1045.
104. Sullivan J.E., Williams R.V., Wisecarver J., Etzel K., Jetton M.M., Magee D.F., 1981. The zinc content of bile and pancreatic juice in zinc-deficient swine. Proc. Soc. Exp. Biol. Med., 166, 39-43.
105. Swiatkiewicz S., Koreleski J., Zhong D., 2001. The bioavailability of zinc from inorganic and organic sources in broiler chickens as affected by addition of phytase. J. Anim. Feed Sci, 10, 317-328.
106. Swinkels J.W.G.M., Kornegay E.T., Versiegen M.W.A., 1994. Biology of zinc and biological value of dietary organic zinc complexes and chelates. Nutr. Res. Rev., 7, 129-149.
107. Swinkels J.W.G.M., Kornegay E.T., Zhou W., Lindemann M.D., Webb K.E.Jr., Versiegen M.W.A., 1996. Effectiveness of a zinc amino acid chelate and zinc sulfate in restoring serum and soft tissue zinc concentrations when fed to zinc-depleted pigs. J. Anim. Sci, 74, 2420-2430.
108. Tucker H.F., Salmon W.D., 1955. Parakeratosis or zinc deficiency disease in the pig. Proc. Soc. Exp. Biol. Med., 28, 613-616.
109. Underwood E.J., 1977. Zinc. In: Trace Elements in Human and Animal Nutrition, Ed. 4, 196-242. Academic Press Inc., London, UK.
110. rd edition) , 477-512. CABI Publishing, Wallingford, UK.
111. Vallee B.L., 1983. Zinc in biology and biochemistry. In: Spiro T.G. (eds), Zinc Enzymes, 1-24. Wiley Interscience publication, John Wiley, New-York.
112. Vallee B.L., Falchuk K.H., 1993. The biochemical basis of zinc physiology. Physiol. Rev., 73, 79-118.
113. Wedekind K.J., Hortin A.E., Baker, D.H., 1992. Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide. J. Anim. Sci, 70, 178-187.
114. Wedekind K.J., Lewis A.J., Giesemann M.A., Miller P., 1994. Bioavailability of zinc from inorganic and organic sources for pigs fed corn-soyabean meal diets. J. Anim. Sci., 72, 2681-2689.
115. Windisch V.W., Kirchgessner M., 1993. Zinc exchange in adult rat at different zinc supply. In: Anke M., Meissner D. and Mills C.F. (eds), Trace Elements in Man and Animals - TEMA 8, 351-355. Verlag Media Touristik, Gersdorf, Germany.
116. Windisch V.W., Kirchgessner M., 1994. Distribution and exchange of zinc in different tissue fractions at deficient and excessive zinc supply. 3. Effect of different zinc supply on quantitative zinc exchange in the metabolism of adult rats. J. Anim. Physiol. a. Anim. Nutr., 71, 131-139.