Can an arbitrary sequence evolve towards acquiring a biological function?

Journal of Molecular Evolution

Volumn 56, Issue 2, 2003, Pages 162-168

  Hayashi, Yuuki ^a   Sakata, Hiroshi ^a   Makino, Yoshihide ^a   Urabe, Itaru ^a   Yomo, Tetsuya ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Directed evolution; Displayed phage; Domain substitution; G3p protein; Infectivity; Population size; Random polypeptide

Indexed keywords

ANTIBODY; POLYPEPTIDE;

ARTICLE; BACTERIOPHAGE; DIRECTED MOLECULAR EVOLUTION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC SELECTION; INFECTION; MOLECULAR CLONING; NONHUMAN; PHAGE DISPLAY; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIOPHAGES; BASE SEQUENCE; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; GENE LIBRARY; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SELECTION (GENETICS); TETRACYCLINE RESISTANCE; VIRAL FUSION PROTEINS;

UNIDENTIFIED BACTERIOPHAGE;

EID: 0037308696     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-002-2389-y     Document Type: Article

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