Effects of phenobarbital and multiple-dose corticosteroids on developmental outcome at age 7 years

Obstetrics and Gynecology

Volumn 101, Issue 2, 2003, Pages 363-373

  Thorp, James A ^a,b,c,d,e,f   O'Connor, Mary ^a,b,c,d,e,f   Belden, Brian ^a,b,c,d,e,f   Etzenhouser, Janice ^a,b,c,d,e,f   Hoffman, Edward L ^a,b,c,d,e,f   Jones, Philip G ^a,b,c,d,e,f  

^a Sacred Heart Health System   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c ST LUKE S HOSPITAL   (United States)

^d CHILDREN S MERCY HOSPITAL   (United States)

^e Special Care Pediatrics   (United States)

^f Analytic Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETAMETHASONE; MAGNESIUM SULFATE; PHENOBARBITAL; PLACEBO; VITAMIN K GROUP;

ACHIEVEMENT; ADULT; ARTICLE; BRAIN DEVELOPMENT; BRAIN HEMORRHAGE; CHILD BEHAVIOR; CHILD DEVELOPMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FETUS; FOLLOW UP; HEAD CIRCUMFERENCE; HUMAN; INTELLIGENCE; INTELLIGENCE QUOTIENT; INTELLIGENCE TEST; MAJOR CLINICAL STUDY; NEWBORN; OUTCOMES RESEARCH; PRENATAL EXPOSURE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; READING; SCHOOL CHILD; SCORING SYSTEM; SIDE EFFECT; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; INTELLIGENCE; MALE; MULTIVARIATE ANALYSIS; PHENOBARBITAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; TIME FACTORS; WECHSLER SCALES;

EID: 0037308662     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(02)02509-7     Document Type: Article

References (31)

1. Reinisch J.M., Sanders S.A. Early barbiturate exposure The brain, sexually dimorphic behavior and learning . Neurosci Biobehav Rev. 6:1982;311-319.
2. Reinisch J.M., Sanders S.A., Mortensen E.L., Psych C., Rubin D.B. In utero exposure to phenobarbital and intelligence deficits in adult men. JAMA. 274:1996;1518-1524.
3. Vanoverloop D., Schnell R.R., Harvey E.A., Holmes L.B. The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function at 4 to 8 years of age. Neurotoxicol Teratol. 14:1992;329-335.
4. Dessens A.B., Cohen-Kettenis P.T., Mellenbergh G.J., Koppe J.G., van De Poll N.E., Boer K. Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems. Acta Paediatr. 89:2000;533-541.
5. van der Pol M.C., Hadders-Algra M., Huisjes H.J. Antiepileptic medication in pregnancy Late effects on children's central nervous system development . Am J Obstet Gynecol. 164:1991;121-128.
6. Fishman R.H.B., Yanai J. Long-lasting effects of early barbiturates on central nervous system and behavior. Neurosci Biobehav Rev. 7:1983;19-28.
7. Bergman A., Rosselli-Austin L., Yedwab G., Yanai J. Neuronal deficits in mice following phenobarbital exposure during various periods in fetal development. Acta Anat. 108:1980;370-373.
8. Yanai J., Fares F., Gavish M., Greenfeld Z., Katz Y., Marcovici G., et al. Neural and behavioral alterations after early exposure to phenobarbital. Neurotoxicology. 10:1989;543-554.
9. Thorp J.A., O'Connor M., Jones A.M.H., Hoffman E.L., Belden B. Does perinatal phenobarbital exposure affect developmental outcome at age 2 years? Am J Perinatol. 16:1999;51-60.
10. Weichsel M.E. The therapeutic use of glucocorticoid hormones in the perinatal period Potential neurological hazards . Ann Neurol. 2:1977;364-366.
11. Uno H., Lohmiller L., Thieme C., Kemnitz J.W., Engle M.J., Roecker E.B., et al. Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Dev Brain Res. 53:1990;157-167.
12. Prodanov D., Mantchev G., Iliev A., Traykov V., Yakimova K., Kaneva R., et al. Effects of dexamethasone in rat neonatal model of axotomy-induced motoneuronal cell death. Arch Physiol Biochem. 106:1998;355-361.
13. Tsubota S., Adachi N., Chen J., Yorozuya T., Nagaro T., Arai T. Dexamethasone changes brain monoamine metabolism and aggravates ischemic neuronal damage in rats. Anesthesiology. 90:1999;515-523.
14. Huang W.L., Beazley L.D., Quinlivan J.A., Evans S.F., Newnham J.P., Dunlop S.A. Effect of corticosteroids on brain growth in fetal sheep. Obstet Gynecol. 94:1999;213-218.
15. Aghajafari F., Murphy K., Willan A., Ohlsson A., Amankwah K., Matthews S., et al. Multiple courses of antenatal corticosteroids A systematic review and meta-analysis . Am J Obstet Gynecol. 185:2001;1073-1080.
16. Quinlivan J.A., Evans S.F., Dunlop S.A., Beazley L.D., Newnham J.P. Use of corticosteroids by Australian obstetricians - a survey of clinical practice. Aust N Z J Obstet Gynaecol. 38:1998;1-7.
17. French N.P., Hagan R., Evans S.F., Godfrey M., Newnham J.P. Repeated antenatal corticosteroids Size at birth and subsequent development . Am J Obstet Gynecol. 180:1999;114-121.
18. Abbasi S., Hirsch D., Davis J., Tolosa J., Stouffer N., Debbs R., et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol. 182:2000;1243-1249.
19. Thorp J.A., Jones P.G., Knox E., Clark R.H. Does antenatal corticosteroid therapy affect birth weight and head circumference? Obstet Gynecol. 99:2002;101-108.
20. Vermillion S.T., Soper D.E., Newman R.B. Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy. Am J Obstet Gynecol. 183:2000;810-814.
21. Banks B.A., Merrill J.D., Cnaan A., Morgan M.A., Parer J.T., Merrill J.D., et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates. Am J Obstet Gynecol. 181:1999;709-717.
22. Thorp J.A., Ferrette-Smith D., Gaston L.A., Johnson J., Yeast J.D., Meyer B.A. Antepartum vitamin K and phenobarbital for preventing intracranial hemorrhage in the premature newborn A randomized, double-blind, placebo-controlled trial . Obstet Gynecol. 86:1995;1-8.
23. Johnson R.A., Wichern D.W. Applied multivariate statistical analysis. 3rd ed:1992;Prentice-Hall Inc, Englewood Cliffs, New Jersey.
24. Valaes T., Kipouros K., Petmezaki S., Solman M., Doxiadis S.A. Effectiveness and safety of prenatal phenobarbital for prevention of neonatal jaundice. Pediatr Res. 14:1980;947-952.
25. Shankaran S., Woldt E., Nelson J., Bedard M.P., Delaney-Black V. Antenatal phenobarbital exposure and neonatal outcome II Neurodevelopmental outcome at 36 months . Pediatrics. 97:1996;649-652.
26. Shankaran S., Papile L.A., Wright L.L., Ehrenkranz R.A., Mele L., Lemons J.A., et al. The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants. N Engl J Med. 337:1997;466-471.
27. Shankaran S., Papile L.A., Wright L.L., Ehrenkranz R.A., Mele L., Lemons J.A., et al. Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure. Am J Obstet Gynecol. 187:2002;171-177.
28. Barker D.J.P., Osmond C., Goldings J., Kuh K., Wadsworth M.E.J. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br Med J. 298:1989;564-567.
29. Barker D.J.P., Winter P.D., Osmond C., Margetts B., Simmonds S.J. Weight in infancy and death from ischaemic heart disease. Lancet. 2:(8663):1989;577-580.
30. Welberg L.A., Seckl J.R. Review article Prenatal stress, glucocorticoids and the programming of the brain . J Neuroendocrinol. 13:2001;113-128.
31. Doyle L.W., Ford G.W., Davis N.M., Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci. 98:2000;137-142.