Update on granulosa cell tumours of the ovary

Current Opinion in Obstetrics and Gynecology

Volumn 15, Issue 1, 2003, Pages 33-37

  Stuart, Gavin C E ^a   Dawson, Lesa M ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Granulosa cell; Inhibin; Ovarian tumours

Indexed keywords

INHIBIN; MOLECULAR MARKER; PROTEIN P53;

CANCER STAGING; CLINICAL FEATURE; GENE MUTATION; GRANULOSA CELL TUMOR; MEDICAL DECISION MAKING; MITOSIS INDEX; MOLECULAR BIOLOGY; OVARY TUMOR; PATHOGENESIS; PATHOLOGY; POSTMENOPAUSE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SEX CORD TUMOR;

ADOLESCENT; ADULT; AGE DISTRIBUTION; BIOPSY, NEEDLE; FEMALE; FOLLOW-UP STUDIES; GRANULOSA CELL TUMOR; HUMANS; INCIDENCE; INHIBINS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OVARIAN NEOPLASMS; RISK ASSESSMENT; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 0037306311     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001703-200302000-00005     Document Type: Review

References (21)

1. Hartmann LC, Young RH, Podratz KC. Ovarian sex cord-stromal tumors. In: Hoskins WJ, Perez CA, Young RC, editors. Principles and practice of gynecologic oncology, 3rd ed. Lippincott Williams and Wilkins. Chapter 36:1075-1093. This book chapter presents a good overview about what is known about stromal tumours of the ovary including GCTs.
2. Miller BE, Barron BA, Dockter ME, et al. Parameters of differentiation and proliferation in adult granulosa cell tumors of the ovary. Cancer Detect Prevent 2001; 25:48-54. An excellent review of the molecular pathology of GCTs of the ovary collectively derived from three institutions.
3. Fujimoto T, Sakuragi N, Okuyama K, et al. Histopathological prognostic factors of adult granulosa cell tumors of the ovary. Acta Obstet Gynecol Scand 2001; 80:1069-1074. A detailed analysis of the histopathotogy of GCTs and the microscopic appearance in a group of 27 patients.
4. A detailed analysis of the histopathotogy of GCTs and the microscopic appearance in a group of 27 patients. McCluggage WG. Value of inhibin staining in gynecological pathology. Int J Gynecol Pathol 2001; 20:79-85. The author discusses the overall role of inhibin staining in gynaecological pathology.
5. The author discusses the overall role of inhibin staining in gynaecological pathology. Ala-Fossi SL, Aine R, Punnonen R, Maenpaa J. Is potential to produce inhibins related to prognosis in ovarian granulosa cell tumors? Eur J Gynaecol Oncol 2000; 21:187-189.
6. Fuller PJ, Chu S, Fikret S, Burger HG. Molecular pathogenesis of granulosa cell tumours. Elsevier; 2002. pp. 89-96. The authors develop a logical understanding of the basic pathophysiology of GCTs focusing on the basic science components. The consideration of signalling pathways and endocrine feedback loops is very helpful in enhancing the reader's knowledge of this area.
7. Arcellana-Panlilio MY, Egeler RM, et al. Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumours. Genes Chromosomes Cancer 2002; 35:000-000.
8. Woodruff TK. Role of inhibins and activins in ovarian cancer. Cancer Treat Res 2002; 107:293-302. The molecular basis of inhibin function is detailed in this article in a logical and sequential manner as welt as the role in ovarian cancer.
9. Cooke I, O'Brien M, Charnock FM, et al. Inhibin as a marker for ovarian cancer. Br J Cancer 1995; 71:1046-1050.
10. Robertson DM, Stephenson T, Pruysers E, et al. Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancer. J Clin Endocrinol Metab 2002; 87:816-824. This is a very good review of the assays and methodology used in measuring inhibin levels. It will assist in the understanding of inhibin forms.
11. Burger HG, Fuller PJ, Chu S, et al. The inhibins and ovarian cancer. Mol Cell Endocrinol 2001; 180: 145-148. For the reader to understand the role of inhibins in ovarian cancer, this is an excellent article with the full scope of ovarian neoplasms being addressed. The role in GCTs is addressed but is not the focus of the manuscript.
12. Gebhart JB, Roche PC, Keeney GL, et al. Assessment of inhibin and p53 in granulosa cell tumors of the ovary. Gynecot Oncol 2000; 77:232-236.
13. King LA, Okagaki T, Gallup DG, et al. Mitotic count, nuclear atypia and immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2 and p53 expression in granulosa cell tumours of the ovary: mitotic count and Ki-67 are indicators of poor prognosis. Gynecol Oncol 1996; 61:227-232.
14. Sharony R, Aviram R, Fishman A, et al. Granulosa cell tumors of the ovary: do they have any unique ultrasonographic and color Doppler flow features? Int J Gynecol Cancer 2001; 11:229-233. This study compares the ultrasonographic features of GCTs with those of epithelial tumours of the ovary in a very detailed manner.
15. This study compares the ultrasonographic features of GCTs with those of epithelial tumours of the ovary in a very detailed manner. Al-Badawi IA, Brasher PM, Ghatage P, et al. Postoperative chemotherapy in advanced ovarian granulosa cell tumors. Int J Gynecol Cancer 2002; 12:119-123. The authors present a review of the literature on surgical management of GCTs and report a case series that supports the role of aggressive surgery.
16. Homesley HD, Bundy BN, Hurteau JA, Roth LM. Bleomycin, etoposide and cisplatin combination therapy of ovarian granulosa cell tumours and other stromal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol 1999; 72:131-137.
17. Robertson DM, Stephenson T, Pruysers E, et al. Inhibins/activins as diagnostic markers for ovarian cancer. Mol Cell Endocrinol 2002; 191:97-103. The authors of this manuscript summarize exceptionally well what is currently known about the role of inhibins in ovarian cancer. The assays for inhibin are also discussed.
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19. Dubuc-Lissoir J, Berthiaume MJ, Boubez G, et al. Case report: bone metastasis from a granulosa cell tumor of the ovary. Gynecol Oncol 2001; 83:400-404.
20. Merras-Salmio L, Vettenranta K, Möttönen M, Heikinheimo M. Ovarian granulosa cell tumors in childhood. Pediatr Hematol Oncol 2002; 19:145-156. This is an excellent review of childhood GCTs with a report of three new cases. Particular emphasis is made of the clinical management.
21. Powell JL, Connor GP, Henderson G. Case report: management of recurrent juvenile granulosa cell tumor of the ovary. Gynecol Oncol 2001; 81:113-116.