In vitro stability study of methotrexate in blood and plasma samples for routine monitoring

Therapeutic Drug Monitoring

Volumn 25, Issue 1, 2003, Pages 81-87

  Limelette, Nadège ^a   Ferry, Mathieu ^a   Branger, Stéphanie ^a   Thuillier, Alain ^a   Fernandez, Christine ^b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Blood samples; Drug monitoring; Methotrexate; Stability

Indexed keywords

METHOTREXATE; THEOPHYLLINE;

ARTICLE; BLOOD; BLOOD SAMPLING; CENTRIFUGATION; CONTROLLED STUDY; COOLING; DRUG DETERMINATION; DRUG MONITORING; DRUG STABILITY; HUMAN; IN VITRO STUDY; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; ROOM TEMPERATURE;

CHROMATOGRAPHY, LIQUID; DRUG MONITORING; DRUG STABILITY; HUMANS; METHOTREXATE; TEMPERATURE;

EID: 0037304724     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200302000-00012     Document Type: Article

References (14)

1. Pommier Y, Lokiec F. Le méthotrexate. Chimiother Antican 1981;31:3083-9.
2. Moore MJ, Erlichman C. Therapeutic drug monitoring in oncology: problems and potential in antineoplastic therapy. Clin Pharmacokin 1987;13:205-27.
3. McLeod H. Therapeutic drug monitoring opportunities in cancer therapy. Pharmacol Ther 1971;74:39-54.
4. Le Guellec C, Gaudet ML, Lamanetre S, et al. Stability of rifampicin in plasma: consequences for therapeutic monitoring and pharmacokinetic studies. Ther Drug Monit 1997;19:669-74.
5. Dyvik O, Grislingaas AL, Tonnesen HH, et al. Methotrexate in infusion solution - a stability test for the hospital pharmacy. J Clin Hosp Pharm 1986;11:343-8.
6. Lawson GJ, Dixon PF. Rapid and simple method for the measurement of methotrexate and 7-OH-methotrexate in serum by HPLC. J Chromatogr B 1981;223:225-31.
7. Cossolo W, Drummer OH, Christophidis N. Comparison of high performance liquid chromatography and the Abbott fluorescent polarization radioimmunoassay in the measurement of methotrexate. J Chromatogr A 1989;494:201-8.
8. Najjar TA, Matar KM, Alfawaz IM. Comparison of a new HPLC method with fluorescence polarization immunoassay for analysis of methotrexate. Ther Drug Monit 1992;14:142-6.
9. Clauwaert KM, Van Bocxlaer JF, De Leenheer AP. Stability study of the designer drugs "MDA, MDMA and MDEA" in water, serum, whole blood and urine under various storage temperatures. Forensic Sci Int 2001;124:36-42.
10. El Mahjoub A, Staub C. Stability of benzodiazepines in whole blood samples stored at varying temperatures. J Pharm Biomed Anal 2000;23:1057-63.
11. Hadidi KA, Oliver JS. Stability of morphine and buprenorphine in whole blood. Int J Legal Med 1998;111:165-7.
12. Dufresne C, Favetta P, Paradis C, et al. Stability of sufentanil in human plasma samples. Ther Drug Monit 2001;23:550-2.
13. Bush V, Blennerhasset J, Wells A, et al. Stability of therapeutic drugs in serum collected in vacutainer serum separator tubes containing a new gel (SST II). Ther Drug Monit 2001;23:259-62.
14. Shen DD, Azarnoff DL. Clinical pharmacokinetics of methotrexate. Clin Pharmacokin 1978;3:1-13.