Anti-inflammatory and analgesic effects of Drypemolundein A, a sesquiterpene lactone from Drypetes molunduana

Pharmaceutical Biology

Volumn 41, Issue 1, 2003, Pages 26-30

  Nkeh, Benedicta Chungag Anye ^a   Njamen, Dieudonné ^a   Wandji, Jean ^a   Fomum, Zacharias Tanee ^a   Dongmo, Alain ^b   Nguelefack, Telesphore Benoît ^c   Wansi, Duplex ^a   Kamanyi, Albert ^c  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b UNIVERSITY OF DOUALA   (Cameroon)

^c UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

Analgesic; Anti inflammatory activity; Drypemolundein A; Drypetes molunduana (Euphorbiaceae)

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; DRYPEMOLUNDEIN A; DRYPETES MOLUNDUANA EXTRACT; FURANOSESQUITERPENE LACTONE; INDOMETACIN; LIGNAN; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; SESQUITERPENE LACTONE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BARK; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG ISOLATION; DRYPETES MOLUNDUANA; EDEMA; FEMALE; INHIBITION KINETICS; LABORATORY DIAGNOSIS; MALE; MEDICINAL PLANT; NONHUMAN; PLANT STEM; RAT; STRUCTURE ANALYSIS;

ANIMALIA; DRYPETES; DRYPETES MOLUNDUANA; EUPHORBIACEAE;

EID: 0037303690     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.41.1.26.14704     Document Type: Article

References (9)

1. Di Rosa M, Willoughby DA (1971): Screens of antiinflammatory drugs. J Pharm Pharmacol 23: 297-298.
2. Flower RJ, Gryglewski R, Herbaczyska-Credo K, Vane JR (1972): Effects of antiinflammatory drugs on prostaglandin biosynthesis. Nature New Biol 238: 104-106.
3. Flower RJ, Moncada S, Vane RJ (1985): Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout. In: Goodman LS, Gilman A, eds., The Pharmacological Basis of Therapeutics. 6th Ed., pp. 682-728.
4. Heptinstall S, Awang DV, Dawson BA, Kindack D, Knight DW, May J (1992): Parthenolide content and bioactivity of feverfew Tanacetum partrhenium (L.). J Pharm Pharmacol 44: 391-395.
5. Hutchinson J, Dalziel M (1958): Flora of West Tropical Africa. 2nd Ed. Vol. 1, Part 2. The Whitefrias Press, Ltd, London and Tonbridge, pp. 377-383.
6. Hwang D, Fisher NH, Jang BC, Tak H, Kim JK, Lee W (1996): Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones correlates with the inhibition of MAP kinases. Biochem Biophys Res Commun 226: 810-818.
7. 13C-NMR spectra of pentacyclic triterpenoids. A compilation and some salient features. Phytochemistry 37: 1517-1575.
8. Safayhi H, Sailer E-R (1997): Anti-inflammatory actions of pentacyclic triterpenes. Planta Med 63: 487-493.
9. Wandji J, Wansi JD, Fuendjiep V, Dagne E, Mulholland DA, Tillequin F, Fomum ZT, Sondengam BL, Nkeh BC, Njamen D (2000): Sesquiterpene lactone and a Friedelane derivative from Drypetes molunduana. Phytochemistry 54: 811-815.