The dose-dependent effects of fentanyl on rat skeletal muscle microcirculation in vivo

Anesthesia and Analgesia

Volumn 96, Issue 2, 2003, Pages 456-462

  Brookes, Zoë L S ^a   Brown, Nicola J ^a   Reilly, Charles S ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; FENTANYL; HYPNORM; SODIUM CHLORIDE;

ANALGESIA; ANESTHESIA; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTERIOLE; ARTICLE; BOLUS INJECTION; CONSCIOUSNESS; CONTROLLED STUDY; DOSE RESPONSE; IN VIVO STUDY; MAINTENANCE THERAPY; MALE; MICROCIRCULATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; VASOCONSTRICTION; VASODILATATION; VENULE;

ANALGESICS, OPIOID; ANIMALS; ARTERIOLES; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; FENTANYL; HEART RATE; MALE; MICROCIRCULATION; MUSCLE, SKELETAL; PAIN MEASUREMENT; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; RESTRAINT, PHYSICAL; VENULES;

EID: 0037302787     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200302000-00030     Document Type: Article

References (25)

1. Tammisto T, Takki S, Toikka P. A comparison of the circulatory effects in man of the analgesics fentanyl, pentazocine and pethidine. Br J Anaesth 1970;42:317-24.
2. Lang RM, Marcus RH, Neumann A, et al. A time course study of the effects of pentobarbital, fentanyl and morphine chloralose on myocardial mechanics. Am J Physiol 1992;73:143-50.
3. Nussenmeir NA, Benthuysen JL, Stiffy EP, et al. Cardiovascular, respiratory and analgesic effects of fentanyl in unanesthetized rhesus monkeys. Anesth Analg 1991;72:221-6.
4. Hutchins PM, Marshburn TH, Maultsby, et al. Long-term microvascular response to hydralazine in spontaneously hypertensive rats. Hypertension 1988;12:74-9.
5. Smith TL, Osbourne SW, Hutchins PM. Long-term macro- and microcirculatory measurements in conscious rats. Microvasc Res 1985;29:360-70.
6. Brookes ZL, Brown NJ, Reilly CS. Intravenous anaesthesia and the rat microcirculation: the dorsal microcirculatory chamber. Br J Anaesth 2000;58:901-3.
7. Albrecht E, Heinrich N, Lorenz D, et al. Influence on continuous levels of fentanyl in rats on the mu-opioid receptor in the central nervous system. Pharmacol Biochem Behav 1997;58:189-94.
8. Cadet P, Bilfinger TV, Fimiani C, et al. Human vascular and cardiac endothelia express mu opiate receptor transcripts. Endothelium 2000;7:185-91.
9. Bachelard H, Pitre M. Regional hemodynamic effects of mu-, delta- and kappa-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious unrestrained rats. Br J Pharmacol 1995;115:613-21.
10. Toda N, Hatano Y. Alpha-adrenergic blocking action of fentanyl on the isolated aorta of the rabbit. Anesthesiology 1977;46: 411-6.
11. Feuerstein G, Powell E, Faden AI. Central effects of mu, delta, and kappa receptor agonists in hemorrhagic shock. Peptides 1985;6:11-3.
12. May CN, Whitehead CJ, Mathias CJ. The pressor response to central administration of beta-endorphin results from a centrally mediated increase in noradrenaline release and adrenaline secretion. Br J Pharmacol 1991;102:639-44.
13. Carlsson C, Smith DS, Keykhah MM, et al. The effects of high-dose fentanyl on cerebral circulation and metabolism in rats. Anesthesiology 1982;57:375-80.
14. Monitto CL, Kurth CD. The effects of fentanyl, sufentanil, and alfentanil on cerebral arterioles in piglets. Anesth Analg 1993; 76:985-9.
15. White DA, Reitan JA, Kien ND, Thorup SJ. Decrease in vascular resistance in the isolated canine hindlimb after graded doses of alfentanil, fentanyl, and sufentanil. Anesth Analg 1990;71:29-34.
16. Medvedev OS, Martynova ER, Hoque AM. Effects of mu- and delta-opiate receptor agonists on systemic and regional hemodynamics in conscious rats. In: Stumpe KO, Kraft K, Faden AI, eds. Opioid peptides and blood pressure control. Berlin: Springer Verlag, 1988:159-67.
17. Yaster M, Koehler RC, Traystman RJ. Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs. Anesthesiology 1987;66:524-30.
18. Hutchins PM, Goldstone J, Wells R. Effects of hemorrhagic shock on the microvasculature of skeletal muscle. Microvasc Res 1973;5:131-40.
19. Miller FN, Joshua JG, Anderson GL. Quantification of vasodilator induced macromolecular leakage by in vivo fluorescent microscopy. Microvasc Res 1982;24:56-67.
20. 3 opiate receptor in endothelial cells. J Biol Chem 1995;270: 30290-3.
21. Milde LN, Milde JH, Gallagher WJ. Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg 1990;70:138-46.
22. Parra L, Perez-Vizicaino F, Alsasua A, et al. Mu and deltaopioid receptor mediated contractile effects on rat aortic vascular smooth muscle. Eur J Pharmacol 1995;277:99-105.
23. Ward ME. Interaction between hypoxia and hypercapnia in regulating canine diaphragm arteriolar diameter. J Appl Physiol 1996;80:802-9.
24. Marshall JM. The influence of the sympathetic nervous system on individual vessels of the microcirculation of skeletal muscle of the rat. J Physiol 1982;332:169-86.
25. Brookes ZL, Brown NJ, Reilly CS. Effects of haemorrhage on the rat mesenteric microcirculation in vivo during intravenous anaesthesia. Br J Anaesth 2002;88:255-63.