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Bekersky I, Boswell GW, Hiles R, Fielding RM, Buell D, Walsh TJ: Safety, toxicokinetics and tissue distribution of long-term intravenous liposomal amphotericin B (AmBisome): A 91-day study in rats. Pharm Res (2000) 17(12):1494-1502. This paper provides detailed information about the biodistribution of repeated dosing of AmBisome and sustained drug tissue levels post-treatment.
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Leenders ACAP, De Marie S, Ten Kate MT, Bakker-Woudenberg IA, Verbrugh HA: Liposomal amphotericin B (AmBisome) reduces dissemination of infection as compared with amphotericin B deoxycholate (Fungizone) in a rat model of pulmonary aspergillosis. J Antimicrob Chemother (1996) 38(2):215-225. This paper describes the effectiveness of high-dose AmBisome in preventing fungal dissemination from the lungs to other tissues.
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Clemons KV, Sobel RA, Williams PL, Pappagianis D, Stevens DA: Efficacy of intravenous liposomal amphotericin B (AmBisome) against coccidioidal meningitis in rabbits. Antimicrob Agents Chemother (2002) 46(8):2420-2426. This paper supports the use of high-dose AmBisome for difficult to treat central nervous system infections, such as coccidioidal meningitis.
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Van Etten EW, Van Den Heuvel-De Groot C, Bakker-Woudenberg IA: Efficacies of amphotericin B-desoxycholate (Fungizone), liposomal amphotericin B (AmBisome) and fluconazole in the treatment of systemic candidosis in immunocompetent and leucopenic mice. J Antimicrob Chemother (1993) 32(5):723-739. This paper describes the sustained bioactivity of high-dose AmBisome for the treatment of kidney infections.
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Ortoneda M, Capilla J, Pastor FJ, Pujol I, Guarro J: Efficacy of liposomal amphotericin B in treatment of systemic murine fusariosis. Antimicrob Agents Chemother (2002) 46(7):2273-2275. This paper shows the improved efficacy of high-dose AmBisome for difficult to treat infections, such as fusariosis.
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Gangneux JP, Sulahian A, Garin YJ, Farinotti R, Derouin F: Therapy of visceral leishmaniasis due to Leishmania infantum: Experimental assessment of efficacy of AmBisome. Antimicrob Agents Chemother (1996) 40(5):1214-1218. This paper describes the efficacy of high-dose AmBisome for treating a systemic infection which localizes in the RES and non-RES tissues, the sustained bioactivity of AmBisome in the tissues and a correlation between tissue drug concentration and drug efficacy.
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Clearance of Candida albicans from infected vaginal tissues of immunosuppressed mice following treatment with AmBisome
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Gibbs DM, Olson JA, Adler-Moore JP: Clearance of Candida albicans from infected vaginal tissues of immunosuppressed mice following treatment with AmBisome. Am Soc Microbiol (2002) 102:Abs F48.
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Gibbs, D.M.1
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Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis
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note
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Yardley V, Croft SL: Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis. Antimicrob Agents Chemother (1997) 41(4):752-756. This paper demonstrates that intravenously administered AmBisome can biodistribute to the skin as evidenced by the efficacy of high-dose AmBisome for resolving skin lesions.
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Llanos-Cuentas A, Echevarria J, Chang P, Campos J, Cieza D, Lentnek D, Gonzalez M, Robbins JB, Williams R: Randomized trial of amphotericin B complex (ABLC) versus Fungizone in patients with mucocutaneous leishmaniasis. Mem Inst Oswaldo Cruz (1991) 86(Suppl 1):238.
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41
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Efficacy of AmBisome (AMBI) loading dose regimens for the treatment of systemic candidiasis in immunosuppressed mice
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Olson JA, Adler-Moore JP, Proffitt RT: Efficacy of AmBisome (AMBI) loading dose regimens for the treatment of systemic candidiasis in immunosuppressed mice. 9th Annual Focus on Fungal Infections, San Diego, CA, USA (1999):Abs 022.
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Garcia A, Adler-Moore JP, Proffitt RT: Single-dose AmBisome (Liposomal amphotericin B) as prophylaxis for murine systemic candidiasis and histoplasmosis. Antimicrob Agents Chemother (2000) 44(9):2327-2332. This paper describes the efficacy of intravenous AmBisome for prophylaxis and a correlation between the efficacy and tissue drug concentration at the time of fungal challenge.
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Allen SD, Sorensen KN, Nejdl MJ, Durrant C, Proffitt RT: Prophylactic efficacy of aerosolized liposomal (AmBisome) and non-liposomal (Fungizone) amphotericin B in murine pulmonary aspergillosis. J Antimicrob Chemother (1994) 34(6):1001-1013. This paper describes the efficacy of aerosolized AmBisome for prophylaxis and the high drug levels in the lungs achieved by the aerosol route of administration.
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J Antimicrob Chemother
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Correlation between drug lung concentrations, colony forming units (CFU) and survival following AmBisome (AmBi) or Abelcet (Ablt) treatment of pulmonary aspergillosis in immunosuppressed mice
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Abs J-1835
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Olson JA, Adler-Moore JA: Correlation between drug lung concentrations, colony forming units (CFU) and survival following AmBisome (AmBi) or Abelcet (Ablt) treatment of pulmonary aspergillosis in immunosuppressed mice. ICAAC (2001) 41:Abs J-1835.
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Croft SL, Davidson RN, Thornton EA: Liposomal amphotericin B in the treatment of visceral leishmaniasis. J Antimicrob Chemother (1991) 28(Suppl B):111-118.
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Proffitt RT, Satorius A, Chiang S-M, Sullivan L, Adler-Moore JP: Pharmacology and toxicology of a liposomal formulation of amphotericin B (AmBisome) in rodents. J Antimicrob Chemother (1991) 28(Suppl B):49-61.
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50
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0033943712
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Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system
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Groll AH, Giri N, Petraitis V, Petraitiene R, Candelario M, Bacher JS, Piscitelli SC, Walsh TJ: Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system. J Infect Dis (2000) 182(1):274-282. This paper describes the comparative efficacy of different amphotericin B lipid formulations in treating an infection of the central nervous system and the increased penetration of AmBisome into the brain.
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J Infect Dis
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, pp. 274-282
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Groll, A.H.1
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Bacher, J.S.6
Piscitelli, S.C.7
Walsh, T.J.8
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