CCK regulates pancreatic enzyme secretion via short duodenal-pancreatic reflexes in pigs

Scandinavian Journal of Gastroenterology

Volumn 38, Issue 2, 2003, Pages 201-206

  Evilevitch, Lena ^a   Westrom B R ^a   Pierzynowski, S G ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

CCK A receptors; Exocrine pancreas; Regulation

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; PANCREAS ENZYME; PROTEIN; TRYPSIN;

ANIMAL EXPERIMENT; ARTICLE; CATHETER; CONTROLLED STUDY; DOSE CALCULATION; DUODENUM; ENZYME RELEASE; JUGULAR VEIN; NONHUMAN; PANCREAS; PANCREAS SECRETION; PRIORITY JOURNAL; STOMACH; SWINE;

ANIMALS; BENZODIAZEPINES; CHOLECYSTOKININ; DUODENUM; MUSCARINIC ANTAGONISTS; PANCREAS; PANCREATIC JUICE; PIPERIDINES; RECEPTOR, CHOLECYSTOKININ A; RECEPTOR, MUSCARINIC M3; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, MUSCARINIC; REFLEX; SWINE; TRYPSIN;

EID: 0037300797     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520310000708     Document Type: Article

References (28)

1. Holst JJ, Schaffalitzky de Muckadell OB, Fahrenkrug J. Nervous control of pancreatic exocrine secretion in pigs. Acta Physiol Scand 1979;105:33-51.
2. Lesniewska V, Gregard A, Westrom B, Hedemann MS, Laerke HN, Kruszewska D, et al. The role of cholinergic and peptidergic pathways in the regulation of pancreatic exocrine function during postnatal development in pigs. Exp Physiol 2001;86:399-409.
3. Singer MV Neurohormonal control of pancreatic enzyme secretion in animals. New York: Raven Press; 1993.
4. Pierzynowski SG, Rehfeld JF, Olsen O, Karlsson S, Ahrén B, Podgurniak M, et al. Mode of exocrine pancreatic function and regulation in pigs at weaning. In: Pierzynowski SG, Zabielski R, editors. Biology of the pancreas in growing animals. Amsterdam: Elsevier Science B.V.; 1999.
5. Collins SM, Abdelmoumene S, Jensen RT, Gardner JD. Cholecystokinin-induced persistent stimulation of enzyme secretion from pancreatic acini. Am J Physiol 1981;240:G459-65.
6. Sankaran H, Goldfine ID, Bailey A, Licko V, Williams JA. Relationship of cholecystokinin receptor binding to regulation of biological functions in pancreatic acini. Am J Physiol 1982;242:G250-7.
7. Cuber JC, Corring T, Levenez F, Bernard C, Chayvialle JA. Effects of cholecystokinin octapeptide on the pancreatic exocrine secretion in the pig. Can J Physiol Pharmacol 1989;67:1391-7.
8. Lhoste EF, Gueugneau AM, Garofano A, Philippe C, Levenez F, Corring T. Role of CCK in the regulation of secretion and adaptation in the pig pancreas. Pancreas 1995;11:86-94.
9. Morisset J, Levenez F, Corring T, Benrezzak O, Pelletier G, Calvo E. Pig pancreatic acinar cells possess predominantly the CCK-B receptor subtype. Am J Physiol 1996;271 (2 Pt 1):E397-402.
10. Philippe C, Lhoste EF, Dufresne M, Moroder L, Corring T, Fourmy D. Pharmacological and biochemical evidence for the simultaneous expression of CCKB/gastrin and CCKA receptors in the pig pancreas. Br J Pharmacol 1997;120:447-54.
11. Bourassa J, Laine J, Kruse ML, Gagnon MC, Calvo E, Morisset J. Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors. Biochem Biophys Res Commun 1999;260:820-8.
12. Pierzynowski SG, Mårtensson H, Weström B, Ahrén B, Uvnäs-Moberg K, Karlsson B. Cholecystokinin (CCK-33) can stimulate pancreatic secretion by a local intestinal mechanism in the pig. Biomed Res 1993;14:217-21.
13. Kiela P, Zabielski R, Podgurniak P, Midura M, Barej W, Gregory P, et al. Cholecystokinin-8 and vasoactive intestinal polypeptide stimulate exocrine pancreatic secretion via duodenally mediated mechanisms in the conscious pig. Exp Physiol 1996;81:375-84.
14. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988;24:739-68.
15. Holzer PSW, Lippe IT, Sametz W. Involvement of capsaicin-sensitive sensory neurons in gastrointestinal function. Acta Physiol Hung 1987;69:403-11.
16. Miyasaka K, Ohta M, Kanai S, Sato Y, Masuda M, Funakoshi A. Role of cholecystokinin (CCK)-A receptor for pancreatic growth after weaning: a study in a new rat model without gene expression of the CCK-A receptor. Pancreas 1996;12:351-6.
17. Blackshaw LA, Grundy D. Effects of cholecystokinin (CCK-8) on two classes of gastroduodenaI vagal afferent fibre. J Auton Nerv Syst 1990;31:191-201.
18. Zarbin MA, Wamsley JK, Innis RB, Kuhar MJ. Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve. Life Sci 1981;29:697-705.
19. Moran TH, Smith GP, Hostetler AM, McHugh PR. Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res 1987;415:149-52.
20. Owyang C. Physiological mechanisms of cholecystokinin action on pancreatic secretion. Am J Physiol 1996;271 (1 Pt 1):G1-7.
21. Gregory PC, Wolf KU, Eeckhout C, Waldeck H, Preuschoff U. Influence of CCK-A, CCK-B antagonists on CCK-8-induced satiety, gallbladder emptying and blockade of gastric emptying in the mouse. Regul Peptides 1992;40:163.
22. Rådberg K, Botermans J, Weström BR, Pierzynowski SG. Depressive effects of anesthesia or sedation on exocrine pancreatic function in pigs. Lab Anim Sci 1999;49:662-4.
23. Zabielski R, Lesniewska V, Borlak J, Gregory PC, Kiela P, Pierzynowski SG, et al. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept 1998;78:113-23.
24. Lowry OH, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75.
25. Pierzynowski SG, Weström BR, Svendsen J, Karlsson BW. Development of exocrine pancreas function in chronically cannulated pigs during 1-13 weeks of postnatal life. J Pediatr Gastroenterol Nutr 1990;10:206-12.
26. Pierzynowski SG, Podgurniak P, Olsen O, Weström B, Karlsson B. Effects of halothane anaesthesia and vagal cold-blockade on the exocrine pancreatic secretion in pigs. In: Soufrant W-B, Hagemeister H, editors. Forschugsinstitut fur die Biologie landwirtschaftlicher Nutztiere (FBN), Schriftenreihe 3,4. The VIth International Symposium on Digestive Physiology in Pigs, 1994; Dummerstorf, Bad Doberan, Germany: EAAP publication; 1994:408-10.
27. Zabielski R, Pierzynowski SG, Podgurniak P, Sharma P, Barej W. Effects of secretin and cholecystokinin octapeptide (CCK8) on exocrine pancreas during cold vagal blockade in calves. J Anim Physiol. A. Anim Nutr 1992;67:173-80.
28. Schweiger M, Erhard MH. Amselgruber WM. Cell-specific localization of the cholecystokinin-A receptor in the porcine pancreas. Anat Histol Embryol 2000;29:357-61.