A homodimeric sporamin-type trypsin inhibitor with antiproliferative, HIV reverse transcriptase-inhibitory and antifungal activities from wampee (Clausena lansium) seeds

Biological Chemistry

Volumn 384, Issue 2, 2003, Pages 289-293

  Ng, Tzi B ^a   Lam, Sze K ^a   Fong, Wing P ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Antifungal; Sporamin; Trypsin inhibitor; Wampee

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIFUNGAL AGENT; BUFFER; CELLULOSE; CHYMOTRYPSIN; DIMER; PROTEINASE K; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRYPSIN; TRYPSIN INHIBITOR; VIRUS ENZYME;

AMINO ACID SEQUENCE; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BOTRYTIS CINEREA; CELL STRAIN HEPG2; CELL STRAIN HL 60; CONTROLLED STUDY; COPRINUS COMATUS; DRUG ISOLATION; FUNGUS; FUSARIUM OXYSPORUM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR WEIGHT; MYCOSPHAERELLA ARACHIDICOLA; NONHUMAN; PHYSALOSPORA PIRICOLA; PLANT; PLANT SEED; PRIORITY JOURNAL; RABBIT; RETICULOCYTE LYSATE; WAMPEE;

BOTRYOTINIA FUCKELIANA; BOTRYTIS; BOTRYTIS CINEREA; CLAUSENA; CLAUSENA LANSIUM; COPRINUS; COPRINUS COMATUS; FUNGI; FUSARIUM; FUSARIUM OXYSPORUM; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LANSIUM; MYCOSPHAERELLA; MYCOSPHAERELLA ARACHIDICOLA; ORYCTOLAGUS CUNICULUS; PHYSALOSPORA; PHYSALOSPORA PIRICOLA; SPERMATOPHYTA;

EID: 0037298753     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.032     Document Type: Article

References (34)

1. Batista, I.F., Oliva, M.L., Araujo, M.S., Sampaio, M.U., Richardson, M., Fritz, H. and Sampaio, C.A. (1996). Primary structure of a Kunitz-type trypsin inhibitor from Enterolobium contortilisiquum seeds. Phytochemistry 41, 1017-1022.
2. Birk, Y. (1985). The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans. Int. J. Peptide Protein Res. 25, 113-131.
3. Chen, Z.Y., Brown, R.L., Lax, A.R., Guo, B.Z., Clevelard, T.E. and Russin, J.S. (1998). Resistance to Aspergillus flavus in corn kernels is associated with a 14-kDa protein. J. Phytopathol. 88, 276-291.
4. Chen, Z.Y., Brown, R.L., Russin, J. S., Lax, A.R. and Cleveland, T.E. (1999). A corn trypsin inhibitor with antifungal activity inhibits Aspergillus flavus α-amylase. Phytopathology 89, 902-907.
5. Chilosi, G., Caruso, C., Caporale, C, Leonardi, L., Bertini, L., Buzi, A. and Nobile, M. (2000). Antifungal activity of a Bowman-Birk type trypsin inhibitor from wheat kernel. J. Phytopathol. 148, 477-481.
6. Collins, R.A., Ng, T.B., Fong, W.P., Wan, C.C. and Yeung, H.W. (1997). A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of Chinese medicinal herbs. Life Sci. 60, PL 345-351.
7. Gruber, A., Berlit, J., Speth, C., Lass, F.C., Dierich, M.P. and Wuerzner, R. (1999). Dissimilar attenuation of Candida albicans virulence properties by human immunodeficiency virus type 1 protease inhibitors. Immunobiology 201, 133-144.
8. Huang, B., Ng, T.B., Fong, W.P., Wan, C.C. and Yeung, H.W. (1999). Isolation of a trypsin inhibitor with deletion of N-terminal pentapeptide from the seeds of Momordica cochinchinensis, the Chinese drug mubiezhi. Int. J. Biochem. Cell Biol. 31, 707-715.
9. Johnson, R., Narvaez, J., An, G. and Ryan, C. (1989). Expression of proteinase inhibitors I and II in transgenic tobacco plants: effects on natural defense against Manduca sexta larvae. Proc. Natl. Acad. Sci. USA 86, 9871-9875.
10. Joshi, B.N., Sainani, M.N., Bastawade, K.B., Gupta, V.S. and Ranjekar, P.K. (1998). Cysteine protease inhibitor from pearl millet: a new class of antifungal protein. Biochem. Biophys. Res. Commun. 246, 382-387.
11. Kennedy, A.R. (1998). Chemopreventive agents: protease inhibitors. Pharmacol. Ther. 78, 167-209.
12. Laemmli, U.K. and Favre, M. (1973). Gel electrophoresis of proteins. J. Mol. Biol. 80, 575-599.
13. Lam, S.K. and Ng, T.B. (2001). First simultaneous isolation of a ribosome inactivating protein and an antifungal protein from a mushroom (Lyophyllum shimeiji) together with evidence for synergism of their antifungal effects. Arch. Biochem. Biophys. 393, 271-280.
14. Lam, S.S.L., Wang, H.X. and Ng, T.B. (1998). Purification and characterization of novel ribosome inactivating proteins, α-and β-pisavins, from seeds of the garden pea Pisum sativum. Biochem. Biophys. Res. Commun. 253, 135-142.
15. Ng, T.B., Huang, B., Fong, W.P. and Yeung, H.W. (1997). Anti-human immunodeficiency virus (anti-HIV) natural products with special emphasis on HIV reverse transcriptase inhibitors. Life Sci. 61, 933-949.
16. Ooi, L.S.M., Ng, T.B., Geng, Y. and Ooi, V.E.C. (2000). Lectins from bulbs of the Chinese daffodil Narcissus tazetta (family Amaryllidaceae). Biochem. Cell Biol. 78, 463-468.
17. Tamir, S., Bell, J., Finlay, T.H., Sakal, E., Smirnoff, P., Gaur, S. and Birk, Y. (1996). Isolation, characterization and properties of a trypsin-chymotrypsin inhibitor from amaranth seeds. J. Protein Chem. 15, 219-229.
18. Tashiro, M., Asao, T., Hirata, C. and Takahashi, K. (1991). Purification, characterization and amino acid sequence of foxtail millet trypsin inhibitor III. Agric. Biol. Chem. 55, 419-426.
19. Terras, F.R.G., Schoofs, H.M.E., Thevissen, K., Osborn, R.W., Vanderleyden, J., Cammue, B.R.A. and Broekaert, W.F. (1993a). Synergistic enhancement of the antifungal activity of wheat thionins by radish and oilseed rape 2S albumins and by barley trypsin inhibitors. Plant Pathol. 103, 1311-1319.
20. Terras, F.R.G., Torrekens, S., Van Leuven, F., Osborn, R.W., Vanderleyden, J., Cammue, B.P.A. and Broekaert, W.F. (1993b). A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. FEBS Lett. 316, 233-240.
21. Tommee, J.F.C., Hiemstra, P.S., Heinzel, W.R. and Kauffman, H.F. (1997). Antileukoprotease: an endogenous protein in the innate mucosal defense against fungi. J. Infect, Dis. 176, 740-747.
22. Tommee, J.F.C., Koeter, G.H., Hiemstra, P.S. and Kauffman, H. (1998). Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option? Thorax 53, 114-116.
23. Troll, W. and Kennedy, A.R. (1993). Protease Inhibitors as Cancer Chemopreventive Agents (New York, USA: Plenum Press).
24. Vernekar, J.V., Ghatge, M.S., and Deshpande, V.V. (1999). Alkaline protease inhibitor: a novel class of antifungal proteins against phytopathogenic fungi. Biochem. Biophys. Res. Commun. 262, 702-707.
25. Wang, H.X. and Ng, T.B. (2000). Ginkbilobin, a novel antifungal protein with sequence similarity to embryo-abundant protein. Biochem. Biophys. Res. Commun. 279, 407-411.
26. Wang, H.X. and Ng, T.B. (2002). Ascalin, a new anti-fungal peptide with human immunodeficiency virus type 1 reverse transcriptase-inhibiting activity from shallot bulbs. Peptides 23, 1025-1029.
27. Wang, X.Y., Ye, X.Y. and Ng, T.B. (2001). Purification of chrysancorin, a novel antifungal protein with mitogenic activity from garland chrysanthemum seeds. Biol. Chem. 382, 947-951.
28. Ye, X.Y. and Ng, T.B. (2000a). Mungin, a novel cyclophilin-like antifungal protein from the mung bean. Biochem. Biophys. Res. Commun. 273, 1111-1115.
29. Ye, X.Y. and Ng, T.B. (2000b). Hypogin, a novel antifungal peptide from peanuts with sequence similarity to peanut allergen. J. Peptide Res. 57, 330-336.
30. Ye, X.Y., Wang, H.X. and Ng, T.B. (2000a). Sativin, a novel antifungal miraculin-like protein isolated from the legumes of the sugar snap Pisum sativum var. macrocarpon. Life Sci. 67, 775-781.
31. Ye, X.Y., Wang, H.X. and Ng, T.B. (2000b). Dolichin, a new chitinase-like antifungal protein isolated from field beans (Dolichos lablab). Biochem. Biophys. Res. Commun. 269, 155-159.
32. Ye, X.Y., Wang, H.X. and Ng, T.B. (2000c). Structurally dissimilar proteins with antiviral and antifungal potency from cowpea (Vigna unguiculata) seeds. Life Sci. 67, 3199-3207.
33. Yeh, K.W., Chen, I.C., Lin, M.I., Chen, Y.M. and Lin, C.Y. (1997). Functional activity of sporamin from sweet potato (Ipomoea batatas Lam): a tuber storage protein with trypsin inhibitory activity. Plant. Mol. Biol. 33, 565-570.
34. Zhao, M., Naude, R.J., Muramoto, K. and Oelofsen, W. (1996). Purification and characterization of ostrich pancreatic secretory trypsin inhibitor. Int. J. Pept. Protein Res. 48, 174-181.