Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate

Regulatory Toxicology and Pharmacology

Volumn 37, Issue 1, 2003, Pages 54-65

  Van Miller, J P ^a   Garman, R H ^b   Hermansky, S J ^c,f   Mirsalis, J C ^d   Frederick, C B ^e,f  

^a Toxicology Regulatory Services   (United States)

^b Consult in Vet Pathology Inc ^*  (United States)

^c UNION CARBIDE CORPORATION   (United States)

^d SRI INTERNATIONAL   (United States)

^e ROHM AND HAAS COMPANY   (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acrylates; Carcinogenesis; Cell proliferation; Methacrylates; Skin irritation; TREGDA; TREGDMA

Indexed keywords

ACRYLIC ACID; ACRYLIC ACID DERIVATIVE; METHACRYLIC ACID; METHACRYLIC ACID DERIVATIVE; TRIETHYLENE GLYCOL; TRIETHYLENE GLYCOL DIMETHACRYLATE; TRIETHYLENEGLYCOL DIACRYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CARCINOGENICITY; CELL DEATH; CELL PROLIFERATION; CHRONIC INFLAMMATION; CHRONIC TOXICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIUM CELL; EVALUATION; HISTOPATHOLOGY; LONG TERM EXPOSURE; MALE; MORTALITY; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; SKIN DEFECT; SKIN INFLAMMATION; SKIN IRRITATION; SKIN TUMOR;

EID: 0037298671     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-2300(02)00027-2     Document Type: Article

References (12)

1. Andrews L.S., Clary J.J. Review of the toxicity of multifunctional acrylates. J. Toxicol. Environ. Health. 19:1986;149-164.
2. Chun, J.S., Negley, J.E., 1992. Fourteen-Day Skin Painting Study II with Triethylene Glycol Diacrylate (TREGDA) and Triethylene Glycol Dimethacrylate (TREGDMA) in Male C3H/HeNHsd Mice. Bushy Run Research Center Project 54-554 [CMA Ref. No. SAM-6.0-BIO-BRRC]. 114 p.
3. DePass L.R., Maronpot R.R., Weil S.S. Dermal oncogenicity bioassays of monofunctional and multifunctional acrylates and acrylate-based oligomers. J. Toxicol. Environ. Health. 16:1985;55-60.
4. Fowler, E.H., Hermansky, S.J., Benson, C.L., 1995a. Triethylene Glycol Diacrylate (TREGDA): Chronic Dermal Bioassay in C3H/HeNHsd Male Mice. Bushy Run Research Center Project 92N168B [CMA Ref. No. SAM-6.0-BIO-BRRC]. 748 p.
5. Fowler, E.H., Hermansky, S.J., Benson, C.L., 1995b. Triethylene Glycol Dimethacrylate (TREGDMA): Chronic Dermal Bioassay in C3H/HeNHsd Male Mice. Bushy Run Research Center Project 92N168A [CMA Ref. No. SAM-6.0-BIO-BRRC]. 710 p.
6. Greenwell A., Foley J.F., Maronpot R.R. An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues. Cancer Lett. 59:1991;251-256.
7. Hermansky, S.J., Negley, J.E., 1992. Ninety-Day Dermal Dose-Finding Study with Triethylene Glycol Diacrylate (TREGDA) and Triethylene Glycol Dimethacrylate (TREGDMA) in Male C3H/HeNHsd Mice. Bushy Run Research Center Project 91N0017 [CMA Ref. No. SAM-6.0-BIO-BRRC]. 357 p.
8. Lawson R.G., Jurs P.C. New index for clustering tendency and its application to chemical problems. J. Chem. Inf. Comput. Sci. 30:1989;36-41.
9. Lawson R.G., Jurs P.C. Cluster analysis of acrylates to guide sampling for toxicity testing. J. Chem. Inf. Comput. Sci. 30:1990;137-144.
10. Mirsalis, J.C., 1992. Cell Proliferation Studies of Triethylene Glycol Diacrylate and Triethylene Glycol Dimethacrylate. SRI International Project LSC-2427, Study No. 2427-S01-91 [CMA Ref. No. SAM-7.0-CP-SRI]. August 21, 1992. 103 p.
11. Mirsalis, J.C., 1993. Cell Proliferation Studies of Triethylene Glycol Diacrylate and Triethylene Glycol Dimethacrylate: PCNA Analysis. SRI International Project LSC-2427 [CMA Ref. No. SAM-7.0-CP-SRI]. July 12, 1993. 15 p.
12. Moss K., Alwood J., Auer C. Acrylate regulation under TSCA. Chem. Health Safety. (May/June):1997;38-41.