Mucosal high apoptotic activity and low p21WAF1/CIP1 expression and submucosal low proliferative activity in superficially spreading early gastric cancers: Comparison with the penetrating growth type

Pathology International

Volumn 53, Issue 2, 2003, Pages 81-89

  Ichinoe, Masaaki ^a   Mitomi, Hiroyuki ^a   Kikuchi, Shiro ^a   Tanabe, Satoshi ^a   Akino, Fumiyuki ^a   Okayasu, Isao ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell kinetics; Early gastric cancer; Growth pattern; Immunohistochemistry; p21WAF1 CIP1; Penetrating growth type; Superficially spreading type

Indexed keywords

KI 67 ANTIGEN; PROTEIN P21;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INCIDENCE; CANCER INVASION; CELL CYCLE; CELL KINETICS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAMINA PROPRIA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH CARCINOMA; SUBMUCOSA; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL COUNT; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DNA, NEOPLASM; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; KINETICS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0037296207     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01438.x     Document Type: Article

References (39)

1. Japanese Research Society for Gastric Cancer. Japanese Classification of Gastric Carcinoma, 1st English edn. Tokyo: Kanehara, 1995.
2. Maehara Y, Orita H, Okuyama T et al. Predictors of lymph node metastasis in early gastric cancer. Br J Surg 1992; 79: 245-47.
3. Kikuchi S, Sakuramoto S, Kobayashi N et al. Tumor volume try: proposal of a new concept to predict lymph node metastasis in early gastric cancer. Anticancer Res 2000; 20: 3669-74.
4. Guadagni S, Catarci M, Kinoshitá T, Valenti M, De Bernardinis G, Carboni M. Causes of death and recurrence after surgery for early gastric cancer. World J Surg 1997; 21: 434-39.
5. Folli S, Dente M, Dell'Amore D et al. Early gastric cancer: prognostic factors in 223 patients. Br J Surg 1995; 82: 952-56.
6. Kodama Y, Inokuchi K, Soejima K, Matsusaka T, Okamura T. Growth patterns and prognosis in early gastric carcinoma. Superficially spreading and penetrating growth types. Cancer 1983; 51: 320-26.
7. Noda H, Maehara Y, Irie K, Kakeji Y, Yonemura T, Sugimachi K. Growth pattern and expressions of cell cycle regulator proteins p53 and p21WAF1/CIP1 in early gastric carcinoma. Cancer 2001; 92: 1828-35.
8. Inokuchi K, Kodama Y, Sasaki O, Kamegawa T, Okamura T. Differentiation of growth patterns of early gastric carcinoma determined by cytophotometric DNA analysis. Cancer 1983; 51: 1138-41.
9. Haraguchi M, Korenaga D, Kakeji Y, Orita H, Maehara Y, Sugimachi K. DNA ploidy is associated with growth potential in gastric carcinoma. Cancer 1991; 68: 2608-11.
10. Ramires M, David L, Leitão D, Seixas M, Sansonetty F, Sobrinho-Simões M. Ki67 labelling index in gastric carcinomas: an immunohistochemical study using double staining for the evaluation of the proliferative activity of diffuse-type carcinomas. J Pathol 1997; 182: 62-67.
11. Yonemura Y, Ooyama S, Sugiyama K et al. Growth fractions in gastric carcinomas determined with monoclonal antibody Ki-67. Cancer 1990; 65: 1130-34.
12. Shinohara T, Ohshima K, Murayama H, Kikuchi M, Yamashita Y, Shirakusa T. Apoptosis and proliferation in gastric carcinoma: the association with histological type. Histopathology 1996; 29: 123-29.
13. Mijic A, Ferencic Z, Belicza M et al. Apoptosis in human gastric polyps and adenocarcinomas: a stereological analysis. Hepatogastroenterology 1998; 45: 684-90.
14. El-Deiry WS, Tokino T, Velculescu VE et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-25.
15. Del, Sal G, Loda M, Pagano M. Cell cycle and cancer: critical events at the G1 restriction point. Crit Rev Oncog 1996; 7: 127-42.
16. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994; 78: 67-74.
17. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994; 78: 59-66.
18. Ichiyoshi Y, Oiwa H, Tomisaki S et al. Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer. Hepatogastroenterology 1997; 44: 546-53.
19. Fonseca L, Yonemura Y, De Aretxabala X, Yamaguchi A, Miwa K, Miyazaki I. p53 detection as a prognostic factor in early gastric cancer. Oncology 1994; 51: 485-90.
20. Gabbert HE, Müller W, Schneiders A, Meier S, Hommel G. The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer 1995; 76: 720-26.
21. Sakaguchi T, Watanabe A, Sawada H et al. Prognostic value of cyclin E and p53 expression in gastric carcinoma. Cancer 1998; 82: 1238-43.
22. Gomyo Y, Ikeda M, Osaki M et al. Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma. Cancer 1997; 79: 2067-72.
23. Müller W, Noguchi T, Wirtz H-C, Hommel G, Gabbert HE. Expression of cell-cycle regulatory proteins cyclin D1, cyclin E, and their inhibitor p21WAF1 / CIP1 in gastric cancer. J Pathol 1999; 189: 186-93.
24. Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma. Cancer 1999; 85: 1711-18.
25. Kip1 loss does not predict survival in patients with advanced gastric carcinoma. Cancer 2000; 89: 1684-91.
26. Sugano H, Nakamura K, Kato Y. Pathological studies of human gastric cancer. Acta Pathol Jpn 1982; 32: 329-47.
27. Takahashi H, Mitomi H, Igarashi M, Katsumasa T, Okayasu I. Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum. Cancer 1999; 85: 796-802.
28. Sada M, Mitomi H, Igarashi M, Katsumasa T, Saigennji K, Okayasu I. Cell kinetics, p53 and bcl-2 expression, and c-Ki-ras mutations in flat-elevated tubulovillous adenomas and adenocarcinomas of the colorectum: comparison with polypoid lesions. Scand J Gastroenterol 1999; 34: 798-807.
29. Watanabe I, Toyoda M, Okuda J et al. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: antibody against single-stranded DNA and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) methods. Jpn J Cancer Res 1999; 90: 188-93.
30. Stout AP. Superficial spreading type of early gastric carcinoma of the stomach. Arch Surg 1942; 44: 651-57.
31. Yasui A, Hirase Y, Miyake M, Kidokoro T, Murakami T. [Pathology of Superficial Spreading Type of Gastric Cancer.] Stomach Intest. 1973; 8: 1305-1310 (in Japanese with English abstract).
32. Aoyagi K, Kohfuji K, Yano S, Terasaki Y, Takeda J, Shirouzu K. [Analysis of early gastric cancers of tumor size <2.0 cm]. Rinshoutokenkyuu 2000; 77: 2300-04 (in Japanese).
33. Yamao T, Shirao K, Ono H et al. Risk factors for lymph node metastasis from intramucosal gastric carcinoma. Cancer 1996; 77: 602-6.
34. Maehara Y, Okuyama T, Moriguchi S et al. Prophylactic lymph node dissection in patients with advanced gastric cancer promotes increased survival time. Cancer 1992; 70: 392-95.
35. Kikuchi S, Hiki Y, Sakakibara Y, Kakita A, Kuwao S. Measuring the tumor volume of gastric carcinoma by computer image analysis: clinical significance. World J Surg 2000; 24: 603-7.
36. Matsusaka T, Kodama Y, Soejima K et al. Recurrence in early gastric cancer: a pathologic evaluation. Cancer 1980; 46: 168-72.
37. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D. Induction of WAF/CIP1 by a p53-independent pathway. Cancer Res 1994; 54: 3391-95.
38. DiGiuseppe JA, Redston MS, Yeo CJ, Kern SE, Hruban RH. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am J Pathol 1995; 147: 884-88.
39. WAF1 but delayed down-regulation of Cdc25A in the TGF-fÀ-induced cell cycle arrest of gastric carcinoma cells. Br J Cancer 1999; 80: 1144-49.