A randomized double-blind trial to compare the clinical efficacy of granisetron with metoclopramide, both combined with dexamethasone in the prophylaxis of chemotherapy-induced delayed emesis

Annals of Oncology

Volumn 14, Issue 2, 2003, Pages 291-297

  Aapro, M S ^a   Thuerlimann, B ^b   Sessa, C ^c   de Pree, C ^d   Bernhard, J ^e   Maibach, R ^e  

^a CLINIQUE DE GENOLIER   (Switzerland)

^b KANTONSSPITAL   (Switzerland)

^c OSPEDALE SAN GIOVANNI   (Switzerland)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e Swiss Inst for Appl Cancer Res   (Switzerland)

Author keywords

Acute; Delayed; Dexamethasone; Granisetron; Nausea; Vomiting

Indexed keywords

CARBOPLATIN; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DACARBAZINE; DEXAMETHASONE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; GRANISETRON; IFOSFAMIDE; IRINOTECAN; METHYLPREDNISOLONE; METOCLOPRAMIDE; ONDANSETRON; PLACEBO; SEROTONIN 3 ANTAGONIST; TACHYKININ RECEPTOR ANTAGONIST; TROPISETRON;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; ASTHENIA; CHEMOPROPHYLAXIS; CHEMOTHERAPY INDUCED EMESIS; CLINICAL PROTOCOL; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EPIGASTRIC PAIN; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HEADACHE; HEALTH CARE COST; HUMAN; INSOMNIA; INVOLUNTARY MOVEMENT; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTIEMETICS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEXAMETHASONE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GRANISETRON; HUMANS; MALE; METOCLOPRAMIDE; MIDDLE AGED; NEOPLASMS; VOMITING;

EID: 0037294667     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdg075     Document Type: Article

References (13)

1. Prevention of chemotherapy- and radiotherapy-induced emesis: results of the Perugia Consensus Conference. Antiemetic Subcommittee of the Multinational Association for Supportive Care in Cancer (MASCC). Ann Oncol 1998; 9: 811-819.
2. Gralla RJ, Navari RM, Hesketh PJ et al. Single-dose oral granisetron has equivalent antiemetic efficacy to intravenous ondansetron for highly emetogenic cisplatin-based chemotherapy. J Clin Oncol 1998; 16: 1568-1573.
3. Perez EA, Hesketh P, Sandbach J et al. Comparison of single-dose oral granisetron versus intravenous ondansetron in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy: a multicenter, double-blind, randomized parallel study. J Clin Oncol 1998; 16: 754-760.
4. Bernhard J, Maibach R, Thürlimann B et al. Patients' estimation of overall treatment burden: why not ask the obvious? J Clin Oncol 2002; 20: 65-72.
5. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549-556.
6. Lan KK, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrics 1983; 70: 659-663.
7. Ondansetron versus metoclopramide, both combined with dexamethasone, in the prevention of cisplatin-induced delayed emesis. The Italian Group for Antiemetic Research. J Clin Oncol 1997; 15: 124-130.
8. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. The Italian Group for Antiemetic Research. N Engl J Med 2000; 342: 1554-1559.
9. Friedman CJ, Burris HA 3rd, Yocom K et al. Oral granisetron for the prevention of acute late onset nausea and vomiting in patients treated with moderately emetogenic chemotherapy. Oncologist 2000; 5: 136-143.
10. Hesketh PJ, Crews JR, Cohen R et al. Antiemetic efficacy of single-dose oral granisetron (1 mg vs 2 mg) with moderately emetogenic chemotherapy. Cancer J Sci Am 2000; 6: 157-166.
11. Double-blind, dose-finding study of four intravenous doses of dexamethasone in the prevention of cisplatin-induced acute emesis. Italian Group for Antiemetic Research. J Clin Oncol 1998; 16: 2937-2942.
12. Kris MG, Gralla RJ, Tyson LB et al. Controlling delayed vomiting: double-blind, randomized trial comparing placebo, dexamethasone alone, and metoclopramide plus dexamethasone in patients receiving cisplatin. J Clin Oncol 1989; 7: 108-114.
13. Diemunsch P, Grelot L. Potential of substance P antagonists as antiemetics. Drugs 2000; 60: 533-546.