Lead discovery of α,β-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 4, 2003, Pages 745-748

  Ni, Liming ^a   Zheng, X Sharon ^a   Somers, Patricia K ^a   Hoong, Lee K ^a   Hill, Russell R ^a   Marino, Elaine M ^a   Suen, Ki Ling ^a   Saxena, Uday ^a   Meng, Charles Q ^a  

^a AtheroGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYL GROUP; SULFONE DERIVATIVE; VASCULAR CELL ADHESION MOLECULE 1; VINYL DERIVATIVE;

ACYLATION; ARTICLE; COMBINATORIAL CHEMISTRY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 0037292989     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)01033-8     Document Type: Article

References (13)

1. Springer T.A. Cell. 76:1994;301.
2. Harris E.D. N. Engl. J. Med. 322:1990;1277.
3. Castano L., Eisenbarth G.S. Annu. Rev. Immunol. 8:1990;647.
4. Zamvil S., Steinman L. Annu. Rev. Immunol. 8:1990;579.
5. Bevilacqua M.P., Nelson R.M., Mannori G., Cecconi O. Annu. Rev. Med. 45:1994;361.
6. Ross R. N. Engl. J. Med. 314:1986;488.
7. Cybulsky M.I., Iiyama K., Li H., Zhu S., Chen M., Iiyama M., Davis V., Gutierrez-Ramos J.C., Conuelly P.W., Milstone D.S. J. Clin. Invest. 107:2001;1255.
8. Foster C.A. J. Allergy Clin. Immunol. 98:1996;S270.
9. Meng C.Q., Zheng X.S., Holt L.A., Hoong L.K., Somers P.K., Hill R.R., Saxena U. Bioorg. Med. Chem. Lett. 11:2001;1823, and references cited therein.
10. Foster C.A., Besemer J., Meingassner J.G., Naegeli H.U., Schon G., Bevec D., Brend T. Skin Pharmacol. 9:1996;149.
11. Oguchi S., Dimayuga P., Zhu J., Chyu K.-Y., Yano J., Shah P.K., Nilsson J., Cercek B. Arterioscler. Thromb. Vasc. Biol. 20:2000;1729.
12. Nakao H., Doi T., Suda M., Umetani M., Ohtaka M., Shiratsuchi M., Kodama T. J. Atheroscler. Thromb. 4:1998;149.
13. 'NE' stands for 'no effect.' For a general protocol used to test compounds for inhibition of inducible VCAM-1 expression, see ref 9.