Cadmium pathways during gestation and lactation in control versus metallothoinein 1,2-knockout mice

Toxicological Sciences

Volumn 71, Issue 2, 2003, Pages 154-163

  Brako, Emmanuel E ^a   Wilson, Allison K ^b   Jonah, Margaret M ^c   Blum, Carmen A ^d   Cerny, Elizabeth A ^d   Williams, Kanesha L ^d   Bhattacharyya, Maryka H ^d  

^a WINONA STATE UNIVERSITY   (United States)

^b BENEDICTINE UNIVERSITY   (United States)

^c DOMINICAN UNIVERSITY   (United States)

^d ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

Cadmium; Gestation; Lactation; Metallothionein; Mice; Pregnancy

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; METALLOTHIONEIN; WATER;

ANIMAL TISSUE; BREAST MILK; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DUODENUM; FEMALE; GESTATIONAL AGE; INTESTINE ABSORPTION; KNOCKOUT MOUSE; LACTATION; METAL BINDING; MILK LEVEL; MOUSE; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; TISSUE LEVEL; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; CADMIUM; CADMIUM RADIOISOTOPES; DRINKING; FEMALE; INTESTINE, SMALL; LACTATION; MALE; MATERNAL-FETAL EXCHANGE; METALLOTHIONEIN; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PLACENTA; PREGNANCY; PREGNANCY, ANIMAL; WATER SUPPLY;

ANIMALIA;

EID: 0037291794     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/71.2.154     Document Type: Review

References (38)

1. Akesson, A., Berglund, M., Schutz, A., Bjellerup, P., Bremme, K., and Vahter, M. (2002). Cadmium exposure in pregnancy and lactation in relation to iron status. Am. J. Public Health 92, 284-287.
2. Bhattacharyya, M. H., Sellers, D. A., and Peterson, D. P. (1986). Postlactational changes in cadmium retention in mice orally exposed to cadmium during pregnancy and lactation. Environ. Res. 40, 145-154.
3. Bhattacharyya, M. H., Whelton, B. D., and Peterson, D. P. (1981). Gastrointestinal absorption of cadmium in mice during gestation and lactation. I. Short-term exposure studies. Toxicol. Appl. Pharmacol. 61, 335-342.
4. Bhattacharyya, M. H., Whelton, B. D., and Peterson, P. D. (1982). Gastrointestinal absorption of cadmium in mice during gestation and lactation. II. Continuous exposure studies. Toxicol. Appl. Pharmacol. 66, 368-375.
5. Bhattacharyya, M. H., Wilson, A. K., Rajan, S. S., and Jonah, M. (2000). Biochemical pathways in cadmium toxicity. In Molecular Biology and Toxicology of Metals (R. K. Zalups and J. Koropatnick, Eds.), pp. 34-74. Taylor and Francis, New York.
6. Chan, H.-M., and Cherian, M. G. (1993). Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats. Biochem. Cell Biol. 71, 133-140.
7. Dawson, D. C., and Ballatori, N. (1995). Membrane transporters as sites of action and routes of entry for toxic metals. In Toxicology of Metals (R. A. Goyer and M. G. Cherian, Eds.), pp. 53-76. Springer-Verlag, Berlin.
8. Dorian, C., Gattone, V. H., II, and Klaassen, C. D. (1995). Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules. Toxicol. Appl. Pharmacol. 130, 161-168.
9. Eaton, D. L., and Cherian, M. G. (1991). Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. Methods Enzymol. 205, 83-88.
10. Floris, B., Bomboi, G., Sechi, P., Pirino, S., Marongiu, M. L. (2000). Cadmium chronic administration to lactating ewes: Reproductive performance, cadmium tissue accumulation and placental transfer. Ann. Chim. 90, 703-708.
11. Frazier, J. M. (1984). Mathematical model for cadmium kinetics in the isolated perfused rat liver system. Toxicol. Appl. Pharmacol. 76, 426-436.
12. Friberg, L., Elinder, C.-G., Kjellstrom, T., and Nordberg, G. F. (1986). Cadmium and Health: A Toxicological and Epidemiological Appraisal, Volume I. Exposure, Dose, and Metabolism. CRC Press, Boca Raton, FL.
13. Goyer, R. A., Haust, M. D., and Cherian, M. G. (1992). Cellular localization of metallothionein in human term placenta. Placenta 13, 349-355.
14. Itoh, N., Fujita, Y., Nakanishi, H., Kawai, Y., Mayumi, T., Hwang, G. S., Min, K., Onosaka, S., Muto, N., and Tanaka, K. (1996). Binding of Cd to metallothionein in the placenta of Cd-treated mouse. J. Toxicol. Sci. 21, 19-27.
15. Jonah, M. M., and Bhattacharyya, M. H. (1989). Early changes in the tissue distribution of cadmium after oral but not intravenous cadmium exposure. Toxicology 58, 325-338.
16. Kondo, Y., Rusnak, J. M., Hoyt, D. G., Settineri, C. E., Pitt, B. R., and Lazo, J. S. (1997). Enhanced apoptosis in metallothionein null cells. Mol. Pharmacol. 52, 195-201.
17. Lau, L. C., Joseph, M. G., and Cherian, M. G. (1998). Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Toxicology 127, 167-178.
18. Lind, Y., and Wicklund-Glynn, A. (1997). The involvement of metallothionein in the intestinal absorption of cadmium in mice. Toxicol. Lett. 91, 179-187.
19. Liu, J., Liu, Y., Michalska, A. E., Choo, K. H., and Klaassen, C. D. (1996a). Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol. 136, 260-268.
20. Liu, J., Liu, Y., Michalska, A. E., Choo, K. H., and Klaassen, C. D. (1996b). Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity. J. Pharmacol. Exp. Ther. 276, 1216-1223.
21. Liu, Y., Liu, J., and Klaassen, C. D. (2001). Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration. Toxicol. Appl. Pharmacol. 175, 253-259.
22. Lucis, O. J., Lucis, R., and Shaikh, Z. A. (1972). Cadmium and zinc in pregnancy and lactation. Arch. Environ. Health 25, 14-22.
23. Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., and Palmiter, R. D. (1994). Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U.S.A. 91, 584-588.
24. Min, K. S., Fujita, Y., Onosaka, S., and Tanaka, K. (1991). Role of intestinal metallothionein in absorption and distribution of orally administered cadmium. Toxicol. Appl. Pharmacol. 109, 7-16.
25. Min, K. S., Nakatsubo, T., Kawamura, S., Fujita, Y., Onosaka, S., and Tanaka, K. (1992). Effects of mucosal metallothionein in small intestine on tissue distribution of cadmium after oral administration of cadmium compounds. Toxicol. Appl. Pharmacol. 113, 306 -310.
26. Michalska, A. E., and Choo, K. H. (1993). Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A. 90, 8088-8092.
27. Ohta, H., and Cherian, M. G. (1991). Gastrointestinal absorption of cadmium and metallothionein. Toxicol. Appl. Pharmacol. 107, 63-72.
28. Ono, S., Cai, L., and Cherian, M. (1998). Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice. Radiat. Res. 150, 52-57.
29. Palmiter, R. D., Findley, S. P., Whitmore, T. E., and Durnam, D. M. (1992). MTIII, a brain-specific member of the metallothionein gene family. Proc. Natl. Acad. Sci U.S.A. 89, 6333-6337.
30. Petersson, G. K., and Oskarsson, A. (2000). Cadmium in milk and mammary gland in rats and mice. Arch. Toxicol. 73, 519-527.
31. Picard, V., Govoni, G., Jabado, N., and Gros, P. (2000). Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J. Biol. Chem. 275, 35738-35745.
32. Quaife, C. J., Findley, S. D., Erickson, J. C., Froelick, G. J., Kelly, E. J., Zambrowicz, B. P. and Palmiter, R. D. (1994). Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 33, 7250-7259.
33. Sasser, L. B., and Jarboe, G. E. (1977). Intestinal absorption and retention of cadmium in neonatal rat. Toxicol. Appl. Pharmacol. 41, 423-431.
34. Sauer, G. R., Nie, D., Wu, L. N., and Wuthier, R. E. (1998). The induction and characterization of metallothionein in chicken epiphyseal growth plate cartilage chondrocytes. J. Cell Biochem. 68, 110-120.
35. Shimada, H., Hochadel, J. F., and Waalkes, M. P. (1997). Progesterone pretreatment enhances cellular sensitivity to cadmium despite a marked activation of the metallothionein gene. Toxicol. Appl. Pharmacol. 142, 178-185.
36. Solaiman, D., Jonah, M. M., Miyazaki, W., Ho, G., and Bhattacharyya, M. H. (2001). Increased metallothionein in mouse liver, kidneys, and duodenum during lactation. Toxicol. Sci. 60, 184-192.
37. Templeton, D. M., and Cherian, M. G. (1991). Toxicological significance of metallothionein. Methods Enzymol. 205, 11-24.
38. Whelton, B. D., Toomey, J. M., and Bhattacharyya, M. H. (1993). Cadmium-109 metabolism in mice. IV. Diet versus maternal stores as a source of cadmium transfer to mouse fetuses and pups during gestation and lactation. J. Toxicol. Environ. Health 40, 531-546.