Mode of action and pharmacokinetic studies of 2-butoxyethanol in the mouse with an emphasis on forestomach dosimetry

Toxicological Sciences

Volumn 71, Issue 2, 2003, Pages 176-189

  Poet, Torka S ^a   Soelberg, Jolen J ^a   Weitz, Karl K ^a   Mast, Terryl J ^a   Miller, Rodney A ^a   Thrall, Brian D ^a   Corley, Richard A ^a  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

2 butoxyethanol; Butoxyacetic acid; Forestomach, dosimetry; Glycol ethers

Indexed keywords

2 BUTOXYETHANOL; ACETIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; BLOOD LEVEL; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETOXIFICATION; EPITHELIUM HYPERPLASIA; EXCRETION; EXPOSURE; FEMALE; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL MUCOSA; GROOMING; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; REVIEW; SALIVA; STOMACH CONTENT; TISSUE LEVEL; TOXICOKINETICS;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; ERYTHROCYTES; ETHYLENE GLYCOLS; FEMALE; GASTROINTESTINAL CONTENTS; HAIR; HALF-LIFE; HEMATOCRIT; LONGEVITY; MALE; MICE; MICE, INBRED STRAINS; SALIVA; STOMACH;

ANIMALIA;

EID: 0037291129     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/71.2.176     Document Type: Review

References (26)

1. ACC (2000). EGBE: A world of solutions. American Chemistry Council Ethylene Glycol Ethers Panel. American Chemistry Council. Available at: http://www.egep.org/. Accessed July, 2000.
2. Bennette, D. (2001). The distribution of radioactivity in the female B6C3F1 mouse following a single intravenous injection of 2-butyox[1-14C]ethanol. Report # CTL/R/1446, Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, UK.
3. Boatman, R. J., and Knaak, J. B. (2001). Ethers of ethylene glycol and derivatives. In Patty's Toxicology, 5th ed. (E. Bingham, A. Cohrssen, and C. H. Powell, Eds.), vol. 7, part D., pp. 73-270. John Wiley and Sons, New York.
4. Corley, R. A., Bormett, G. A., and Ghanayem, B. I. (1994). Physiologically based pharmacokinetics of 2-butoxyethanol and its major metablite, 2-butoxyacetic acid, in rats and humans. Toxicol. Appl. Pharmacol. 129, 61-79.
5. Corley, R. A., Markham, D. A., Banks, C., Delorme, P., Masterman, A. and Houle, J. M. (1997). Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans. Fundam. Appl. Toxicol. 39, 120-130.
6. DeSesso, J. M., and Jacobsen, C. F. (2001). Anatomical and physiological parameters affecting gastsrointestinal absorption in humans and rats. Food. Chem. Toxicol. 39, 209-228.
7. Dill, J. A., Lee, K. M., Bates, D. J., Anderson, D. J., Johnson, R. E., Chou, B. J., Burka, L. T., and Roycroft, J. H. (1998). Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2- butoxyacetic acid, in F344 rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 153, 227-242.
8. ECETOC (1994). European Chemical Industry Ecology and Toxicology Centre. CTL/R/1444, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK. Special Report No. 7. Butoxyethanol Criteria Document Including a Suplement for 2-Butoxyethyl Acetate, April, 1994. Brussels, Belgium.
9. Eldridge, S. R., and Goldsworthy, S. M. (1996). Cell proliferation rates in common cancer target tissues of B6C3F1 mice and F344 rats: Effects of age, gender, and choice of marker. Fundam. Appl. Toxicol. 32, 159-167.
10. Elliot, B. M., and Ashby, J. (1997). Review of the genotoxicity of 2-butoxyethanol. Mutat. Res. 387, 89-96.
11. U.S. EPA (1999). Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE). In Support of Summary Information on the Integrated Risk Information System. IRIS. U.S. Environmental Protection Agency. Available at: http://www.epa.gov/iris. Accessed October, 1999.
12. Farris, E. J. (1998). Age-, gender- and species-comparison of blood and tissue partition coefficients for 2-butoxyacetic acid. Master's Thesis. Washington State University. May, 1998.
13. Ghanayem, B. I., Burka, L. T., and Matthews, H. B. (1987). Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: Role of alcohol and aldehyde dehydrogenases. J. Pharmacol. Exp. Ther. 242, 222-231.
14. Ghanayem, B. I., and Sullivan, C. A. (1993). Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Hum. Exp. Toxicol. 12, 305-311.
15. Green, T. (2001a). The distribution of radioactivity in the female B6C3F1 mouse following a single six-h exposure to 2-butyoxy[1-14C]ethanol by inhalation. Report # CTL/R/1444, Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, U.K.
16. Green, T. (2001b). 2-Butyoxethanol induced forestomach tumours in the mouse: Studies on the modes of action. Report # CTL/R/1445, Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, U.K.
17. Green, T., Toghill, A., Lee, R., Moore, R., and Foster, J. (2002). The development of forestomach tumors in the mouse following exposure to 2-butoxyethanol by inhalation. Studies on the mode of action and relevance to humans. Toxicology 180, 257-273.
18. Kamendulis, L. M., Jiang, J., Xu, Y., and Klaunig, J.E. (1999). Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile. Carcinogenesis 20, 1555-1560.
19. Klaunig, J. E., Xu, Y., Isenberg, J. S., Bachowski, S., Kolaja, K. L., Jiang, J., Stevenson, D. E., and Walborg, E. F., Jr. (1998). The role of oxidative stress in chemical carcinogenesis. Environ. Health Perspect. 106(Suppl. 1), 289-295.
20. Lee, K. M., Dill, J. A., Chou, B. J., and Roycroft, J. H. (1998). Physiologically based pharmacokinetic model for chronic inhalation of 2- butoxyethanol. Toxicol. Appl. Pharmacol. 153, 211-226.
21. NTP (1993). Ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol administered in drinking water to F344/N rats and B6C3F1 mice. National Toxicology Program Technical Report Series No. 26. National Toxicology Program, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. NIH Publication 93-3349. July, 1993.
22. NTP (2000). Technical report on the toxicology and carcinogenesis studies of 2-butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program Technical Report Series No. 484. National Toxicology Program, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. NIH Publication 00-3974, March, 2000.
23. Park, J., Kamendulis, L. M., and Klaunig, J. E. (2002). Effects of 2-butoxyethanol on hepatic oxidative damage. Toxicol. Lett. 126, 19-29.
24. Tyl, R. W., Ballantyne, B., Fisher, L. C., Fait, D. L., Dodd, D. E., Klonne, D. R., Pritts, I. M., and Losco, P. E. (1995). Evaluation of the developmental toxicity of ethylene glycol aerosol in CD-1 mice by nose-only exposure. Fundam. Appl. Toxicol. 27, 49-62.
25. Udden, M. M. (1994). Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility. J. Appl. Toxicol. 14, 97-102.
26. Udden, M. M., and Patton, C. S. (1994). Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: I. Sensitivity in rats and resistance in normal humans. J. Appl. Toxicol. 14, 91-96.