Increased FR-900493 production in Bacillus cereus 2045 by incuding combined gentamicin and rifampicin-resistant mutations

Chinese Journal of Antibiotics

Volumn 28, Issue 1, 2003, Pages 53-54

  Hu, Hai feng ^a   Zhang, Qin ^a   Zhu, Bao quan ^a   Gong, Bing yong ^a   Ochi, Kozo ^b  

^a Shanghai Inst Pharmaceutical I   (China)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN; RIFAMPICIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS CEREUS; BACTERIAL MUTATION; GENOTYPE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

EID: 0037285230     PISSN: 10018689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Hu H F, Zhu B Q, Gong B Y. Screening the bioactive substance and new medicine discovery [J]. World Notes on Antibiotics, 1998,19(6):401
2. Hu H F, Ochi K. Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations [J]. Appl Environ Microbiol, 2001,67 (4):1885
3. Ochi K, Ezaki M, Iwami M, et al. Substance FR-900493, production thereof and drug composition containing the same substance [P]. JP Pat 01-296992,1989-11-30
4. Shima J, Hesketh A, Okamoto S, et al. Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistarnce in Streptomyces lividans and Streptomyces coelicolor A3 (2) [J]. J Bacterial 1996,178:7876