Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution

Journal of Biochemistry

Volumn 133, Issue 1, 2003, Pages 83-91

  Kawasaki, Takashi ^a   Hamano, Yoshimitsu ^a   Kuzuyama, Tomohisa ^b   Itoh, Nobuya ^a   Seto, Haruo ^c   Dairi, Tohru ^a  

^a TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Farnesyl diphosphate synthase; Geranylgeranyl diphosphate synthase; Product specificity; Site directed mutagenesis; Streptomyces

Indexed keywords

FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; GENE MUTATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; STREPTOMYCES ARGENTEOLUS;

ALKYL AND ARYL TRANSFERASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CLONING, MOLECULAR; DIMETHYLALLYLTRANSTRANSFERASE; EUBACTERIUM; FARNESYLTRANSTRANSFERASE; GERANYLTRANSTRANSFERASE; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; STREPTOMYCES; SUBSTRATE SPECIFICITY;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); KITASATOSPORA GRISEOLA; STREPTOMYCES; STREPTOMYCES ARGENTEOLUS; UNCULTURED ACTINOMYCETE;

EID: 0037283967     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvg002     Document Type: Article

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