The development of a practical and reliable large-scale synthesis of 2,6-diamino-4-bromopyridine

Organic Process Research and Development

Volumn 7, Issue 1, 2003, Pages 38-43

  Nettekoven, Matthias ^a   Jenny, Christian ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIBROMOPYRIDINE N OXIDE; 2,6 DIAMINO 4 BROMOPYRIDINE; PYRIDINE 1 OXIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; PROCESS DEVELOPMENT; SAFETY; SCALE UP; SYNTHESIS;

EID: 0037283039     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op020085j     Document Type: Article

References (16)

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10. Purity of 6 was determined by reversed phase analytical HPLC at 230 nm. Purity was generally higher than 90%.
11. 3), 7.20 (s, br, 2H, NH), 7.80 (s, 2H, H3,5). Mp 175.5 °C.
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15. For alternative use of 2,4-dibromo-6-nitropyridine-N-oxide in a medicinal chemistry program, see: Riemer, C.; Borroni, E.; Levet-Trafit, B.; Martin, J. R.; Poli, S.; Porter, R.; Bös, M. J. Med. Chem. 2002. Manuscript submitted.
16. Kowalski P.; Majaka Z.; Kowalska T. Chem. Heterocycl. Comput. 1998. 34, 740-741.