Third pathway: Endothelium-dependent hyperpolarization

Drug Development Research

Volumn 58, Issue 1, 2003, Pages 18-22

  Félétou, Michel ^a   Vanhoutte, Paul M ^b  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Blood vessel; Endothelium; Potassium channel; Smooth muscle; Vasodilatation

Indexed keywords

APAMIN; ARACHIDONIC ACID; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL; CHARYBDOTOXIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; IBERIOTOXIN; INDOMETACIN; N(G) NITROARGININE; POTASSIUM ION; UNSPECIFIC MONOOXYGENASE;

CALCIUM CELL LEVEL; CELL MEMBRANE POTENTIAL; CONFERENCE PAPER; ENDOTHELIUM CELL; ENZYME METABOLISM; EVOKED RESPONSE; GUINEA PIG; HEART ACCESSORY CONDUCTION PATHWAY; HUMAN; HYPERPOLARIZATION; INHIBITION KINETICS; NONHUMAN; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0037282549     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10125     Document Type: Conference Paper

References (17)

1. Beny JL, Pacicca C. 1994. Bidirectional electrical communication between smooth muscle and endothelial cells in the pig coronary artery. Am J Physiol 266:H1465-H1472.
2. Brandes PL, Schmitz-Winnenthal FH, Félétou M, Gödecke A, Huang PL, Vanhoutte PM, Fleming I, Busse R. 2000. An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild type and endothelial NO synthase knock-out mice. Proc Natl Acad Sci USA 57:9747-9752.
3. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. 1996. Identification of epoxyeicosatrienoic acids as derived hyperpolarizing factor. Circ Res 78:415-423.
4. Chataigneau T, Félétou M, Duhault J, Vanhouüe PM. 1998. Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarisation in the guinea-pig carotid artes. Br J Pharmacol 123:574-580.
5. Chaytor AY, Evens WH, Griffith TM. 1998. Central role of heterocellular gap junction communication in endothelium-dependent relaxations of rabbit arteries. J Physiol (Lond) 508:561-573.
6. Edwards G, Weston AH. 1998. Endothelium-derived hyperpolarizing factor - a critical appraisal. Prog Drug Res 50:109-133.
7. + an endothelium-derived hyperpolarizing factor in rat arteries. Nature 396:269-272.
8. Emerson GG, Segal SS. 2000. Electrical coupling between endothelial cells and smooth muscle cells in hamster feed arteries: role in vasomotor control. Circ Res 87:474-479.
9. Félétou M, Vanhoutte PM. 2000. Endothilium-dependent hyperpolarization of vascular smooth muscle cells. Acta Pharmacol Sin 21:1-18.
10. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R. 1999. Cytochrome P4540 2C is an EDHF synthase in coronar), arteries. Nature 401:493-497.
11. Garland CJ, Plane F, Kemp BK, Cocks TM. 1995. Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol Sci 16:23-30.
12. Quilley J, McGiff JC. 2000. Is EDHF an epoxyeicosatrienoic acid? Trends Pharmacol Sci 21:121-124.
13. Vanhoutte PM. 1996. Endothelium-derived hyperpolarizing factor. Amsterdam: Harwood.
14. Vanhoutte PM. 1999. Endothelium-dependent hyperpolarizations. Amsterdam: Hanvood.
15. Vanhoutte PM. 2001. EDHF 2000. London: Taylor and Francis.
16. Yamamoto Y, Imaeda K, Suzuki H. 1999. Endothelium-dependent hyperpolarization and intercellular electrical coupling in guinea-pig mesenteric arterioles. J Physiol (Lond) 514:505-513.
17. Zygmunt PM, Plane F, Paulsson M, Garland CJ, Högestätt ED. 1998. Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF. Br J Pharmacol 124:992-1000.