In vitro kinetics of allergen- and microbe-induced IL-4 and IFN-γ mRNA expression in PBMC of pollen-allergic patients

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 58, Issue 1, 2003, Pages 62-66

  Laaksonen, Kirsi ^a,b   Waris, M ^a   Makela M J ^b   Terho, E O ^a   Savolainen, J ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Allergen; IFN ; IL 4; Kinetics; Tetanus toxin; Tuberculin

Indexed keywords

ALLERGEN; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; TETANUS TOXIN; TUBERCULIN;

ADULT; ARTICLE; BLOOD CELL; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; MALE; MICROORGANISM; MONONUCLEAR CELL; POLLEN ALLERGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA ANALYSIS;

ADULT; ALLERGENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-4; KINETICS; LEUKOCYTES, MONONUCLEAR; MALE; POLLEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 0037282373     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2003.23653.x     Document Type: Article

References (24)

1. WIERENGA E, SNOEK M, JANSEN HM, BOS JD, LIER R, KAPSENBERG ML. Human atopen-specific types 1 and 2 helper cell clones. J Immunol 1991;147:2942-2949.
2. ROMAGNANI S. Biology of human Th1 and Th2 cells. J Clin Immunol 1995;15:121.
3. WIERENGA E, SNOEK M, DE GROOT C et al. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990;144:4651-4656.
4. DEE PRETE G, MAGGI E, PARRONCHI P et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-4198.
5. SCHLEIMER RP, STERBINSKY SA, KAISER J, et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. J Immunol 1992;148:1086-1092.
6. WALSH GM, HARTNELL A, WARDLAW AJ, KURIHARA K, SANDERSON CJ, KAY AB. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/18)-dependent manner. Immunology 1990;71:258-265.
7. THEPEN T, LANGEVELD-WILDSCHUT EG, BIHARI IC et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response to a Th1 response in situ: An immunocytochemical study. J Allergy Clin Immunol 1996;97:828-837.
8. TSICOPOULOS A, HAMID Q, HACZKU A et al. Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals. J Allergy Clin Immunol 1994;94:764-772.
9. DURHAM S, YING S, VARNEY VA et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5 and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: Relationship for tissue eosinophilia. J Immunol 1992;148:2390-2394.
10. ROBINSON DS, HAMID Q, YING S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
11. YING S, DURHAM SR, CORRIGAN CJ, HAMID Q, KAY B. Phenotype of cells expressing mRNA for TH2-Type (Interleukin 4 and Interleukin 5) and TH1-Type (Interleukin 2 and Interferon γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995;12:477-487.
12. BORGER P, TEN HACKEN NHT, VELLENGA E, KAUFFMAN HF, POSTMA DS. Peripheral blood T lymphocytes from asthmatic patients are primed for enhanced expression of interleukin (IL)-4 and IL-5 mRNA. associations with lung function and serum IgE. Clin Exp Allergy 1999;29:772-779.
13. IMADA M, ESTELLE F, SIMONS R, JAY FT, HAYGLASS KT. Allergen-stimulated interleukin-4 and interferon-γ production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunol 1995;85:373-380.
14. MACAUBAS C, SLY PD, BURTON P et al. Regulation of T-helper cell responses to inhalant allergen during early childhood. Clin Exp All 1999;29:1223-1231.
15. SMART JM, KEMP AS. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin Exp Allergy 2002;32:796-802.
16. O'BRIEN RM, XU H, ROLLAND JM, BYRON KA, THOMAS WR. Allergen-specific production of interferon-γ by peripheral blood mononuclear cells and CD8 T cells in allergic disease and following immunotherapy. Clin Exp Allergy 2000;30:333-340.
17. BORISH L, ROSENWASSER L, Th1/Th2 lymphocytes: Doubt some more. J Allergy Clin Immunol 1997;99:161-164.
18. JOHANSSON SGO, HOURIHANE JO'B, BOUSQUET J et al. A revised nomenclature for allergy. Allergy 2001;56:813-824.
19. HALMINEN M, SJÖROOS M, MÄKELÄ MJ et al. Simultaneous detection of IFN-γ and IL-4 mRNAs using RT-PCR and time-resolved fluorometry. Cytokine 1999;11:87-93.
20. MCHUGH S, DEIGHTON J, RIFKIN I, EWAN P. Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol 1996;26:1260-1265.
21. MARCHANT A, GOETHEBUER T, OTA MO, et al. Newborns develop a Th1-type immune response to Mycobacterium boris Bacillus Calmette-Guérin vaccination. J Immunol 1999;163:2249-2255.
22. TILL S, DURHAM S, DICKASON R et al. IL-13 production by allergen-stimulated T cells is increased in allergic disease and associated with IL-5 but not IFN-γ expression. Immunol 1997;91:53-57.
23. ROWE J, MACAUBAS C, MONGER TM et al. Antigen-specific responses to diphtheria-tetanus-acellular pertussis vaccine in human infants are initially Th2 polarized. Infection Immunol 2000;68:3873-3877.
24. KURTZHALS JAL, HANSEN MB, HEY AS, POULSEN LK. Measurement of antigen-dependent interleukin-4 production by human peripheral blood mononuclear cells. J Immunol Meth 1992;156:239-245.