Efficacy and safety of caudal injection of levobupivacaine, 0.25%, in children under 2 years of age undergoing inguinal hernia repair, circumcision or orchidopexy

Paediatric Anaesthesia

Volumn 13, Issue 2, 2003, Pages 114-121

  Taylor, R ^a   Eyres, R ^b   Chalkiadis, G A ^b   Austin, S ^a  

^a ROYAL BELFAST HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Anaesthesia; Bupivacaine; Efficacy; Levobupivacaine; Paediatric

Indexed keywords

BUPIVACAINE; LEVOBUPIVACAINE;

ANALGESIA; ARTICLE; BRADYCARDIA; CHILD; CIRCUMCISION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HERNIOPLASTY; HUMAN; HYPOGLYCEMIA; INFANT; INGUINAL HERNIA; MALE; MULTICENTER STUDY; ORCHIDOPEXY; PAIN ASSESSMENT; PEDIATRIC ANESTHESIA; PRIORITY JOURNAL; RASH; VOMITING;

ANESTHESIA, CAUDAL; ANESTHETICS, LOCAL; BUPIVACAINE; CIRCUMCISION, MALE; FEMALE; HERNIA, INGUINAL; HUMANS; INFANT; INFANT, NEWBORN; MALE; ORCHIECTOMY; STEREOISOMERISM; TIME FACTORS;

EID: 0037282342     PISSN: 11555645     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.2003.01036.x     Document Type: Article

References (35)

1. Bosenberg AT, Barry AR, Bland FF et al. Thoracic epidural anesthesia via caudal route in infants. Anesthesiology 1988; 69: 265-269.
2. Ecoffey C, Dubousset AM, Samii K. Lumbar and thoracic epidural anesthesia for urologic and upper abdominal surgery in infants and children. Anesthesiology 1986; 65: 87-90.
3. Krane EJ, Jacobson LE, Lynn AM et al. Caudal morphine for postoperative analgesia in children: a comparison with caudal bupivacaine and intravenous morphine. Anesth Analg 1987; 66: 647-653.
4. May AE, Wandless J, James RH. Analgesia for circumcision in children. A comparison of caudal bupivacaine and intramuscular buprenorphine. Acta Anaesthesiol Scand 1982; 26: 331-333.
5. Luz G, Innerhofer P, Bachmann B et al. Bupivacaine plasma concentrations during continuous epidural anesthesia in infants and children. Anesth Analg 1996; 82: 231-234.
6. Luz G, Wieser C, Innerhofer P et al. Free and total bupivacaine plasma concentrations after continuous epidural anaesthesia in infants and children. Paediatr Anaesth 1998; 8: 473-478.
7. McCaughey W, Mirakhura RK. Drugs in anaesthetic practice and analgesia. In: Speight TM, Holford NHG, eds. Avery's Drug Treatment, 4th edn. Auckland: Adis International, 1997; 451-514.
8. McCloskey JJ, Haun SE, Deshpande JK. Bupivacaine toxicity secondary to continuous caudal epidural infusion in children. Anesth Analg 1992; 75: 287-290.
9. Gristwood RW, Greaves JL. Levobupivacaine: a new safer long acting local anaesthetic agent. Expert Opinion Invest Drugs 1999; 8: 861-876.
10. Bardsley H, Gristwood R, Watson N et al. The local anaesthetic activity of levobupivacaine does not differ from racemic bupivacaine (Marcaine): first clinical evidence. Expert Opinion Invest Drugs 1997; 6: 1883-1885.
11. Gunter JB, Gregg T, Varughese AM et al. Levobupivacaine for ilioinguinal/iliohypogastric nerve block in children. Anesth Analg 1999; 89: 647-649.
12. Cox CR, Faccenda KA, Gilhooly C et al. Epidural S(-)-bupivacaine: comparison with racemic RS-bupivacaine. Br J Anaesth 1998; 80: 289-293.
13. Kopacz D, Allen H, Thompson G et al. Double-blind randomised trial of 0.75% levobupivacaine compared to 0.75% bupivacaine for epidural anesthesia in patients undergoing major elective abdominal surgery. Reg Anesth Pain Med 1998; 23: 12 (Abstract).
14. Convery PN, Weir P, Quinn P et al. Epidural levobupivacaine for hip arthroplasty anesthesia and analgesia. Reg Anesth Pain Med 1998; 23: 86 (Abstract).
15. Checketts MR, Cox C, MacKenzie N et al. Comparison of levobupivacaine in supraclavicular brachial plexus blockade. Reg Anaesth 1997; 22: 19 (Abstract).
16. McLure HA, Rubin AP. Comparison of 0.75% levobupivacaine with 0.75% racemic bupivacaine for peribulbar anaesthesia. Anaesthesia 1998; 53: 1160-1164.
17. Bay-Nielsen M, Klarskov B, Bech K et al. Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorraphy. Br J Anaesth 1999; 82: 280-282.
18. Murdoch J, Dickson U, Wilson P et al. Levobupivacaine administered as a continuous epidural infusion for postoperative pain in patients undergoing elective orthopaedic surgery. Int Monitor Reg Anaesth 1998; 10: 9 (Abstract).
19. Crews JC, Hord AH, Sudarshan G et al. Analgesic efficacy of epidural levobupivacaine 0.25% and morphine 0.005%, or levobupivacaine 0.25%, in patients following major abdominal surgical procedures. Reg Anesth Pain Med 1998; 23: 72 (Abstract).
20. Åberg G. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol 1972; 31: 278-286.
21. Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from the block during diastole. Anesthesiology 1985; 62: 396-405.
22. Vanhoutte F, Vereecke J, Verbeke N et al. Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle. Br J Pharmacol 1991; 103: 1275-1281.
23. Valenzuela C, Snyders DJ, Bennett PB et al. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation 1995; 92: 3014-3024.
24. Valenzuela C, Delpon E, Tamkun MM et al. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys J 1995; 69: 418-427.
25. Mazoit JX, Boico O, Samii K. Myocardial uptake of bupivacaine. II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart. Anesth Analg 1993; 77: 477-482.
26. Denson DD, Behbehanin MM, Gregg RV. Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovascular system in the anesthetised rat. Reg Anesth 1992; 17: 311-316.
27. Van F, Rolan PE, Brennan N et al. Differential effects of levo-and racemic bupivacaine on the EEG in volunteers. Reg Anesth Pain Med 1998; 23: 48 (Abstract).
28. Bardsley H, Gristwood R, Baker H et al. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol 1998; 46: 245-249.
29. Tiret L, Nivoche Y, Hatton F et al. Complications related to anaesthesia in infants and children. A prospective survey of 40,240 anaesthetics. Br J Anaesth 1988; 61: 263-269.
30. Scherhag A, Kleeman PP, Vrana S et al. Plasma concentrations of bupivacaine for continuous peridural anesthesia in children. Anaesthetist 1998; 47: 202-208 [Article in German].
31. Smith T, Moratin P, Wulf H. Smaller children have greater bupivacaine plasma concentrations after ilioinguinal block. Br J Anaesth 1996; 76: 452-455.
32. Mazoit JX, Denson DD, Samii K. Pharmacokinetics of bupivacaine following caudal anesthesia in infants. Anesthesiology 1988; 68: 387-391.
33. Tucker GT. Pharmacokinetics of local anaesthetics. Br J Anaesth 1986; 58: 717-731.
34. Gristwood R, Bardsley H, Baker H et al. Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcaine): new clinical evidence. Expert Opinion Invest Drugs 1994; 3: 1209-1212.
35. Thomas J, Schug SA. Recent advances in the pharmacokinetics of local anaesthetics. Long-acting amide enantiomers and continuous infusions. Clin Pharmacokinet 1999; 36: 67-83.