Analysis of estrogen receptor (ERα and ERβ) and progesterone receptor (PR) polymorphisms in uterine leiomyomas

Medical Science Monitor

Volumn 9, Issue 1, 2003, Pages

  Massart, Francesco ^a,b   Becherini, Lucia ^b   Marini, Francesca ^b   Noci, Ivo ^b   Piciocchi, Luigi ^b   Del Monte, Francesca ^b   Masi, Laura ^b   Falchetti, Alberto ^b   Tanini, Annalisa ^b   Scarselli, Gianfranco ^b   Brandi, Maria Luisa ^b  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Estrogen receptors; Myometrium; Polymorphisms; Progesterone receptor; Sex hormones; Uterine leiomyoma

Indexed keywords

ENDONUCLEASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE PRODUCT; PROGESTERONE RECEPTOR;

ADULT; AGAR GEL ELECTROPHORESIS; ALLELISM; ARTICLE; CAUCASIAN; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PATHOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PREMENOPAUSE; UTERUS MYOMA;

ADULT; AGED; ALLELES; ELECTROPHORESIS, AGAR GEL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENOTYPE; HUMANS; LEIOMYOMA; MIDDLE AGED; POLYMORPHISM, GENETIC; POSTMENOPAUSE; RECEPTORS, ESTROGEN; UTERINE NEOPLASMS;

EID: 0037277601     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Pokras R, Hufnagel VG: Hysterectomy in the United States, 1965-84. Am J Public Health, 1988; 78: 852-3
2. Vollenhoven BJ, Lawrence AS, Healy DL: Uterine fibroids: a clinical review. Br J Obstet Gynaecol, 1990; 97: 285-98
3. Green S, Walter P, Kumar V et al: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature, 1986; 320: 134-9
4. Enmark E, Pelto-Huikko M, Grandien K et al: Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab, 1997; 82: 4258-65
5. Misrahi M, Venencie PY, Saugier-Veber P et al: Structure of the human progesterone receptor gene. Biochim Biophys Acta, 1993; 1216: 289-92
6. Kniper GG, Carlsson B, Grandien K et al: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 1997; 138: 863-70
7. Kasmer P, Krust A, Turcotte B et al: Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J, 1990; 9: 1603-14
8. Tibbetts TA, Mendoza-Meneses M, O'Malley BW, Conneely OM: Mutual and intercompartmental regulation of estrogen receptor and progesterone receptor expression in the mouse uterus. Biol Reprod. 1998; 59: 1143-52
9. Becherini L, Gennari L, Masi L et al: Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet, 2000; 9: 2043-50
10. Rosenkranz K, Hinney A, Ziegler A et al: Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. J Clin Endocrinol Metab, 1998; 83: 4524-7
11. Wang-Gohrke S, Chang-Claude J, Becher H et al: Progesterone receptor gene polymorphism is associated with decreased risk for breast cancer by age 50. Cancer Res, 2000; 60: 2348-50
12. Tsukamoto K, Inoue S, Hosoi T et al: Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor beta locus. J Hum Genet, 1998; 43: 73-4
13. Massart F, Becherini L, Gennari L et al: Genotype distribution of estrogen receptor alpha gene polymorphisms in Italian women affected by surgical uterine leiomyomas. Fertil Steril, 2001; 75: 567-570
14. Lessl M, Klotzbuecher M, Schoen S et al: Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. J Clin Endocrinol Metab, 1997; 82: 2596-600
15. Potgieter HC, Magagane F, Bester MJ: Oestrogen and progesterone receptor status and PgR/ER ratios in normal and myomatous human myometrium. East Afr Med J, 1995; 72: 510-4
16. Rein MS, Barbieri RL, Friedman AJ: Progesterone: a critical role in the pathogenesis of uterine myomas. Am J Obstet Gynecol, 1995; 172: 14-8
17. Carling T, Rastad J, Kindmark A et al: Estrogen receptor gene polymorphism in postmenopausal primary hyperparathyroidism. Surgery, 1997; 122: 1101-6
18. Brandi ML, Becherini L, Gennari L et al: Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease. Biochem Biophys Res Commun, 1999; 265: 335-8
19. Maruyama H, Toji H, Harrington CR et al: Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease. Arch Neurol, 2000; 57: 236-40
20. Kitawaki J, Obayashi H, Ishihara H et al: Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod, 2001; 16: 51-55
21. Lubahn DB, Moyer JS, Golding TS et al: Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA, 1993; 90: 11162-6
22. Krege JH, Hodgin JB, Couse JF et al: Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA, 1998; 95: 15677-82
23. Kenealy MR, Flouriot G, Sonntag-Buck V et al: The 3'-untranslated region of the human estrogen receptor alpha gene mediates rapid messenger ribonucleic acid turnover. Endocrinology, 2000; 141: 2805-13
24. Rowe SM, Coughlan SJ, McKenna NJ et al: Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion. Cancer Res, 1995; 55: 2743-5
25. Vegeto E, Allan GF, Schrader WT et al: The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell, 1992; 69: 703-13
26. Lancaster JM, Berchuck A, Carney ME et al: Progesterone receptor gene polymorphism and risk for breast and ovarian cancer. Br J Cancer, 1998: 78: 277
27. Britten RJ: Evidence that most human Alu sequences were inserted in a process that ceased about 30 million years ago. Proc Natl Acad Sci USA, 1994; 91: 6148-50
28. Norris J, Fan D, Aleman C et al: Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. J Biol Chem, 1995; 270: 22777-82
29. Li LC, Yeh CC, Nojima D, Dahiya R: Cloning and characterization of human estrogen receptor beta promoter. Biochem Biophys Res Commun, 2000; 275: 682-9
30. Klein-Hitpass L, Schorpp M, Wagner U, Ryffel GU: An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell. 1986: 46: 1053-61
31. Kropotov AV, Tomilin NV: Evidence for a regulatory protein complex on RNA polymerase III promoter of human retroposons of Alu family. Genetica, 1996-97; 98: 223-33