Conversion of a racemic mixture of 8-chloro-2-(2,6-difluorophenylmethyl)- 2,3-dihydro-3-methyl-1,2,5-benzothiadiazepin-4(5H)-one 1,1-dioxide into a single enantiomer via a chromatographic resolution/racemization method

Chirality

Volumn 15, Issue 5, 2003, Pages 429-432

  La Torre, F ^a   Cirilli, R ^a   Ferretti, R ^a   Gallinella, B ^a   Costi, R ^b   Di Santo, R R ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Enantiomer separation; Free energy barrier; Polyacrylamide derivative; Racemization; Rate constant

Indexed keywords

8 CHLORO 2 (2,6 DIFLUOROPHENYLMETHYL) 2,3 DIHYDRO 3 METHYL 1,2,5 BENZOTHIADIAZEPIN 4(5H) ONE 1,1 DIOXIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; POLYACRYLAMIDE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHIRAL CHROMATOGRAPHY; CRYSTAL STRUCTURE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; PRIORITY JOURNAL; RACEMIC MIXTURE; RACEMIZATION; SYNTHESIS;

EID: 0037277248     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10226     Document Type: Article

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