Novel synthesis of N-aroylaminated pyridones via reaction of ketene dithioacetals with cyanoaceto-N-aroylhydrazides

Synthetic Communications

Volumn 33, Issue 2, 2003, Pages 253-258

  Elgemeie, Galal H ^a   Elghandour, Ahmed H ^b   Elzanate, Ali M ^b   Abd Elaziz, Ghada W ^b  

^a Helwan University   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

Heterocycles; Ketene Dithioacetals, cyanoaceto N aroylhydrazides; N aroylaminated pyridones; Unsaturated nitriles

Indexed keywords

ACETAL DERIVATIVE; CYACETAZIDE; CYANIC ACID DERIVATIVE; HYDRAZIDE DERIVATIVE; KETENE DERIVATIVE; KETENE DITHIOACETAL; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; MASS SPECTROMETRY; MELTING POINT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0037276361     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120015710     Document Type: Article

References (6)

1. Elgemeie, G.E.H.; Elghandour, A.H.; Elzanate, A.M.; Ahmed, S.A. Synthesis of some novel α-cyanoketene-S,S-acetals and their use in heterocyclic synthesis. J. Chem. Soc. Perkin Trans. 1, 1997, 3285.
2. Elgemeie, G.E.H.; Ali, H.A.; Elzanate, A.M. The reaction of cyanoketene-dithioacetals with imidazolidinones: a synthesis of methylsulfanylpyrrolo[1,2-c]imidazolones. J. Chem. Research (S) 1996, 340.
3. Elgemeie, G.E.H.; El-Ezbawy, S.R.; Ali, H.A.; Mansour, A.K. Novel synthesis of mercaptopurine and pentaaza-as-indacene analogues: reaction of [bis(methylthio)methylene]malononitrile and ethyl 2-cyano-3,3-bis(methylthio)acrylate with 5-aminopyrazoles. Bull. Chem. Soc. Japan 1994, 67, 738.
4. Elgemeie, G.E.H.; Elghandour, A.H.; Elzanate, A.M.; Ahmed, S.A. Novel synthesis of thioguanine and sulfanylpurine analogues: reaction of heterocyclic ketene dithioacetals with nucleophiles. J. Chem. Research (S) 1998, 162.
5. Soto, J.L.; Seoane, C.; Zamorano, P.; Guadrado, F.J. A convenient synthesis of N-amino-2-pyridones. Synthesis 1981, 529.
6. Elgemeie, G.E.H.; Elghandour, A.H.; Elzanate, A.M.; Masoud, W.A. Novel N-substituted amino-4-methylsulfanyl-2-pyridones and deazapurine analogues from ketene dithioacetals. J. Chem. Research (S) 1998, 164.