Development of a novel soft hydrogel for the transdermal delivery of testosterone

Drug Development and Industrial Pharmacy

Volumn 29, Issue 1, 2003, Pages 99-105

  An, Na Mi ^a   Kim, Dae Duk ^a   Shin, Young Hee ^b   Lee, Chi Ho ^a  

^a Pusan National University   (South Korea)

^b Kyungsung University   (South Korea)

Author keywords

Permeation enhancer; Soft hydrogel; Testosterone; Transdermal delivery

Indexed keywords

1 [2 (DECYLTHIO)ETHYL]AZACYCLOPENTAN 2 ONE; ADHESIVE AGENT; DODECYLAMINE; HPE 101; ISOBUTYLENE; LAURIC ACID; OLEIC ACID; PENETRATION ENHANCING AGENT; POLYISOBUTYLENE; POLYVINYL ALCOHOL; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RADIOIMMUNOASSAY; RAT; SKIN PENETRATION;

ADHESIVES; ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, CUTANEOUS; AMINES; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; HYDROGELS; MALE; POLYENES; POLYMERS; POLYVINYL ALCOHOL; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; TESTOSTERONE;

EID: 0037275796     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120016688     Document Type: Article

References (21)

1. Hardman, J.G.; Limbird, L.E., Eds. In A Goodman and Gilman's the Pharmacological Basis of Therapeutics, 9th Ed.; Macmillan: London, 1996; 1459-1485.
2. Rosenfield, R.L. Role of androgens in growth and development of the fetus, child, and adolescent. Adv. Pediatr. 1972, 19, 172-213.
3. Gennaro, A.R., Ed. Remington: The Science and Practice of Pharmacy, 20th Ed.; Lippincott Williams & Wilkins: Philadelphia, 2000; 1391.
4. Satyannrana, S.; Ganaga, S.; Singh, J. Transport through rat skin from transdermal patch formulations. Pharmazie 1993, 48, 467-468.
5. Morgan, T.M.; Reed, B.L.; Finnin, B.C. Enhanced skin permeation of sex hormones with novel topical spray vehicles. J. Pharm. Sci. 1998, 87 (1), 1213-1218.
6. Morgan, T.M.; Parr, R.A.; Reed, B.L.; Finnin, B.C. Enhanced transdermal delivery of sex hormones in swine with a novel topical aerosol. J. Pharm. Sci. 1998, 87 (1), 1219-1225.
7. Salehian, B.; Wand, C.; Alexander, G.; Davidson, T.; McDonald, V.; Berman, N.; Dudley, R.E.; Zikl, F.; Verdloff, R.S. Pharmacokinetics, bioefficacy and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate - a clinical research center study. J. Clin. Endocr. Metab. 1995, 80 (12), 3567-3575.
8. Kesler, D.J.; Christenson, D.C.; Wallace, M.E. The effect of esterification on their release of testosterone and estradiol from silicone implants. Drug Dev. Ind. Pharm. 1996, 22 (3), 275-279.
9. William, A.C.; Barry, B.W. Skin permeation enhancers. Crit. Rev. Ther. Drug 1992, 9, 305-353.
10. Sugibayashi, K.; Nakyama, S.; Seki, S.; Hosoya, K.; Morimoto, Y. Mechanism of skin penetration-enhancing effect by laurocapram. J. Pharm. Sci. 1992, 81, 58-64.
11. Lee, C.H.; Lee, K.J.; Park, A.J.; Shin, Y.H. Studies on controlled release of indomethacin from PVA hydrogel. Arch. Pharm. Res. 1993, 16, 43-49.
12. Guo, J. Investigation of the surface properties and bioadhesion of buccal patches. J. Pharm. Pharmacol. 1994, 46, 647-650.
13. Kokubo, T.; Sugibayashi, K.; Morimoto, Y. Interaction between drugs and pressure-sensitive adhesives in transdermal therapeutic systems. Pharm. Res. 1994, 11, 104-107.
14. Xiong, G.L.; Quan, D.; Maibach, H.I. Effects of penetration of penetration enhancers on in vitro percutaneous absorption of low molecular weight heparin through human skin. J. Cont. Rel. 1996, 42, 289-296.
15. Hou, S.Y.E.; Flynn, G.L. Enhancement of hydrocortisone permeation of human and hairless mouse skin by 1-dodecylazacycloheptane-2-one. J. Invest. Dermatol. 1989, 93, 774-779.
16. Lambert, W.J.; Higuchi, W.I.; Knutson, K.; Krill, S.L. Dose-dependent enhancement effects of azone on skin permeability. Pharm. Res. 1989, 6, 798-803.
17. Cooper, E.R. Increased skin permeability for lipophilic molecules. J. Pharm. Sci. 1984, 73, 1153-1156.
18. Kim, D.D.; Kim, J.L.; Chien, Y.W. Mutual hairless rat skin permeation enhancing effect of ethanol/water system and oleic acid. J. Pharm. Sci. 1996, 85, 1191-1195.
19. Anungst, B.J.; Blake, J.A.; Hussain, M.A. Contributions of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amines. Pharm. Res. 1990, 7, 712-718.
20. Kim, M.K.; Zhao, H.; Lee, C.H.; Kim, D.D. Formulation of resevoir-type testosterone transdermal delivery system. Int. J. Pharm. 2001, 219, 51-59.
21. Royland, J.E.; Weber, L.J.; Fitzpatrick, M. Testes size and testosterone levels in a model for weightlessness. Life Sci. 1994, 54, 545-554.