Genetic alterations responsible for metastatic phenotypes of lung cancer cells

Clinical and Experimental Metastasis

Volumn 20, Issue 3, 2003, Pages 189-193

  Yokota, Jun ^a   Nishioka, Michiho ^a   Tani, Masachika ^a   Kohno, Takashi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Lung cancer; Metastasis; Multistage carcinogenesis; Tumor suppressor gene

Indexed keywords

MYOSIN; PROTEIN P16; PROTEIN P53;

ADVANCED CANCER; APOPTOSIS; CANCER CELL; CANCER GENETICS; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL GROWTH; CHROMOSOME 22Q; GENE CONTROL; GENE DELETION; GENE INACTIVATION; GENE MUTATION; GENE REPRESSION; HETEROZYGOSITY LOSS; LUNG CANCER; METASTASIS; METHYLATION; MULTIGENE FAMILY; PHENOTYPE; REVIEW;

ADENOCARCINOMA; ANIMALS; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 22; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; MICE; MYOSINS; PHENOTYPE; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037273289     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022978932215     Document Type: Review

References (38)

1. Fearon ER, Vogelstain B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-67.
2. Saha S, Bardelli A, Buckhaults P et al. A phosphatase associated with metastasis of colorectal cancer. Science 2001; 294: 1343-6.
3. Baylin S, Bestor TH. Altered methylation patterns in cancer cell genomics: Cause or consequence? Cancer Cell 2002; 1: 299-305.
4. Kohno T, Yokota J. How many tumor suppressor genes are involved in human lung carcinogenesis? Carcinogenesis 1999; 20: 1403-10.
5. Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol 2001; 28: 3-13.
6. ARF alterations in non-small cell lung carcinoma. Cancer Genet Cytogenet 2003; 141: 5-13.
7. Ookawa K, Shiseki M, Takahashi R et al. Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations. Oncogene 1993; 8: 2175-81.
8. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 1995; 55: 6200-9.
9. Adachi J, Ookawa K, Shiseki M et al. Induction of apoptosis but not G1 arrest by expression of the wild-type p53 gene in small-cell lung carcinoma. Cell Growth Differ 1996; 7: 879-86.
10. Adachi J, Kohno T, Baeg GH et al. Growth suppression of non-small cell lung carcinoma cells by the introduction of the p16INK4A gene. Int J Oncol 1997; 10: 33-9.
11. Adachi J, Ookawa K, Kohno T et al. Phenotypic alteration of small cell lung carcinoma induced by different levels of wild-type p53 expression. Cell Death Differ 1998; 5: 148-55.
12. Sumitomo K, Shimizu E, Shinohara A et al. Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4A gene. Int J Oncol 1999; 14: 1075-80.
13. Aoyagi Y, Yokose T, Minami Y et al. Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res 2001; 61: 7950-4.
14. Tomizawa Y, Kohno T, Kondo H et al. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res 2002; 8: 2362-8.
15. Boyle JO, Lonardo F, Chang JH et al. Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations. Clin Cancer Res 2001; 7: 259-66.
16. Niklinski J, Niklinska W, Chyczewski L et al. Molecular genetic abnormalities in premalignant lung lesions: Biological and clinical implications. Eur J Cancer Prey 2001; 10: 213-26.
17. Wistuba II, Behrens C, Milchgrub S et al. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 1999; 18: 643-50.
18. Wistuba II, Berry J, Behrens C et al. Molecular changes in the bronchial epithelium of patients with small cell lung cancer. Clin Cancer Res 200; 6: 2604-10.
19. Dammann R, Li C, Yoon JH et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 2000; 25: 315-9.
20. Croce CM, Sozzi G, Huebner K. Role of FHIT in human cancer. J Clin Oncol 1999; 17: 1618-24.
21. Baylin SB, Herman JG. Promoter hypermethylation - can this change alone ever designate true tumor suppressor gene function? J Natl Cancer Inst 2001; 93: 664-5.
22. Kawanishi M, Kohno T, Otsuka T et al. Allelotype and replication error phenotype of small cell lung carcinoma. Carcinogenesis 1997; 18: 2057-62.
23. Shiseki M, Kohno T Adachi J et al. Comparative allelotype of early and advanced stage non-small cell lung carcinomas. Genes Chromosomes Cancer 1996; 17: 71-7.
24. Shiseki M, Kohno T, Nishikawa R et al. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. Cancer Res 1994; 54: 5643-8.
25. Nishioka M, Kohno T, Takahashi M et al. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Oncogene 2000; 19: 6251-60.
26. Nishioka M, Kohno T, Tani M et al. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated and methylated in human lung cancer. Proc Natl Acad Sci USA 2002; 99: 12269-74.
27. Girard L, Zochbauer-Muller S, Virmani AK et al. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 2000; 60: 4894-906.
28. Kuramochi M, Fukuhara H, Nobukuni T et al. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 2001; 27: 427-30.
29. Xu XL, Wu LC, Du F et al. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. Cancer Res 2001; 61: 7943-9.
30. Yokota J. Tumor progression and metastasis. Carcinogenesis 2000; 21: 497-503.
31. Doki Y, Murakami K, Yamaura T et al. Mediastinal lymphnode metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice. Br J Cancer 1999; 79: 1121-6.
32. Yamaura T, Murakami K, Doki Y et al. Solitary lung tumors and their spontaneous metastasis in athymic nude mice orthotopically implanted with human non-small cell lung cancer. Neoplasia 2000; 2: 315-24.
33. Nagamachi Y, Tani M, Shimizu K et al. Orthotopic growth and metastasis of human non-small cell lung carcinoma cells injected into the pleural cavity of nude mice. Cancer Lett 1998; 127: 203-9.
34. Mitani N, Murakami K, Yamaura T et al. Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. Cancer Lett 2001; 165: 35-42.
35. Nagamachi Y, Tani M, Shimizu K et al. Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Cancer Gene Therapy 1999; 6: 546-53.
36. Tomizawa Y, Nakajima T, Kohno T et al. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Cancer Res 1998; 58: 5478-83.
37. Tomizawa Y, Kohno T, Fujita T et al. Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. Oncogene, 1999; 18: 1007-14.
38. Tomizawa Y, Adachi J, Kohno T et al. Prognostic significance of allelic imbalances on chromosome 9P in stage I non-small cell lung carcinoma. Clin Cancer Res 1999; 5: 1139-46.