Replication of the Baculovirus Genome

Molecular Biology

Volumn 37, Issue 2, 2003, Pages 250-259

  Mikhailov, V S ^a,b  

^a KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Baculoviruses; DNA replication

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA BINDING PROTEIN; DNA POLYMERASE; DNA PRIMASE; HELICASE; LATE EXPRESSION FACTOR 1; LATE EXPRESSION FACTOR 2; LATE EXPRESSION FACTOR 3; LATE EXPRESSION FACTOR 7; PROTEIN P35; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

BACULOVIRUS; DNA BINDING MOTIF; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA STRUCTURE; DNA SYNTHESIS; ENZYME SUBUNIT; MOLECULAR RECOGNITION; NONHUMAN; REVIEW; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; VIRAL GENETICS; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS REPLICATION;

DNA VIRUSES; UNIDENTIFIED BACULOVIRUS;

EID: 0037272969     PISSN: 00268933     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023349706186     Document Type: Review

References (114)

1. Rohrmann G.F. 1999. in Encyclopedia of Virology. Eds Webster R.G., Granoff A. London: Academic Press, pp. 146-152.
2. Winstanley D., O'Reilly D. 1999. in Encyclopedia of Virology. Eds Webster R.G., Granoff A. London: Academic Press, pp. 140-146.
3. Hayakawa T., Rohrmann G.F., Hashimoto Y. 2000. Patterns of genome organization and content in lepidopteran baculoviruses. Virology. 278, 1-12.
4. Herniou E.A., Luque T., Chen X., Vlak J.M., Winstanley D., Cory J.S., O'Reilly D.R. 2001. Use of whole genome sequence data to infer baculovirus phylogeny. J. Virol. 75, 8117-8126.
5. Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D. 1994. The complete DNA sequence of Autographa californica nuclear polyhedrosis virus. Virology. 202, 586-605.
6. Inceoglu A.B., Kamita S.G., Hinton A.C., Huang Q., Severson T.F., Kang K., Hammock B.D. 2001. Recombinant baculoviruses for insect control. Pest. Manag. Sci. 57, 981-987.
7. Kost T.A., Condreay J.P. 2002. Recombinant baculoviruses as mammalian cell gene-delivery vectors. Trends Biotechnol. 20, 173-180.
8. Ghosh S., Parvez M.K., Banerjee K., Sarin S.K., Hasnain S.E. 2002. Baculovirus as mammalian cell expression vector for gene therapy: an emerging strategy. Molec. Ther. 6, 5-11.
9. Blissard G.W., Rohrmann G.F. 1990. Baculovirus diversity and molecular biology. Annu. Rev. Entomol. 35, 127-155.
10. Kool M., Ahrens C.H., Vlak J.M., Rohrmann G.F. 1995. Replication of baculovirus DNA. J. Gen. Virol. 76, 2103-2118.
11. Ahrens C.A., Leisy D.J., Rohrmann G.F. 1996. in DNA Replication in Eukaryotic Cells. Ed. DePamphilis M. Cold Spring Harbor: Cold Spring Harbor Lab. Press. pp. 855-872.
12. Lu A., Krell P., Vlak J.M., Rohrmann G.F. 1997. In The baculoviruses. Ed. Miller L.K. New York: Plenum Press, pp. 171-192.
13. Okano K., Mikhailov V.S., Maeda S. 1999. Colocalization of baculovirus IE-1 and two DNA-binding proteins, DBP and LEF-3, to viral replication factories. J. Virol. 73, 110-119.
14. Mainz D., Quadt I., Knebel-Morsdorf D. 2002. Nuclear IE2 structures are related to viral DNA replication sites during baculovirus infection. J. Virol. 76, 5198-5207.
15. Leisy D.J., Rohrmann G.F. 1993. Characterization of the replication of plasmids containing hr sequences in baculovirus-infected Spodoptera frugiperda cells. Virology. 196, 722-730.
16. Oppenheimer D.I., Volkman L.E. 1997. Evidence for rolling circle replication of Autographa californica M nucleopolyhedrovirus genomic DNA. Arch. Virol. 142, 2107-2113.
17. Lehman I.R., Boehmer P.E. 1999. Replication of herpes simplex virus DNA. J. Biol. Chem. 274, 28059-28062.
18. Hajos J.P., Pijnenburg J., Usmany M., Zuidema D., Zavodzsky P., Vlak J.M. 2000. High frequency recombination between homologous baculoviruses in cell culture. Arch. Virol. 145, 159-164.
19. O'Reilly D.R., Miller L.K., Luckow V.A. 1992. Baculovirus expression vectors. A laboratory manual. New York: Freeman W.H. and Company.
20. Fu X., Wang H., Zhang X. 2002. High-frequency intermolecular homologous recombination during herpes simplex virus-mediated plasmid DNA replication. J. Virol. 76, 5866-5874.
21. Wu Y., Liu G., Carstens E.B. 1999. Replication, integration, and packaging of plasmid DNA following cotransfection with baculovirus viral DNA. J. Virol. 73, 5473-5480.
22. Cochran M.A., Faulkner P. 1983. Location of homologous DNA sequences interspersed at five regions in the baculovirus AcMNPV genome. J. Virol. 45, 961-970.
23. Pearson M.N., Bjornson R.M., Pearson G.D., Rohrmann G.F. 1992. The Autographa californica baculovirus genome: evidence for multiple replication origins. Science. 257, 1382-1384.
24. Kool M., Voeten J.T.M., Goldbach R.W., Tramper J., Vlak J.M. 1993. Identification of seven putative origins of Autographa californica MNPV DNA replication. J. Gen. Virol. 74, 2661-2668.
25. Pearson M.N., Rohrmann G.F. 1995. Lymantria dispar nuclear polyhedrosis virus homologous regions: characterization of their ability to function as replication origins. J. Virol. 69, 213-221.
26. Habib S., Pandey S., Chatterji U., Burma S., Ahmad R., Jain A., Hasnain S.E. 1996. Bifunctionality of the Ac-MNPV homologous region sequence (hr1): enhancer and ori functions have different sequence requirements. DNA Cell Biol. 15, 737-747.
27. Wu Y., Carstens E.B. 1996. Initiation of baculovirus DNA replication: early promoter regions can function as infection-dependent replicating sequences in a plasmid-based replication assay. J. Virol. 70, 6967-6972.
28. Pearson M.N., Bjornson R.M., Ahrens C., Rohrmann G.F. 1993. Identification and characterization of a putative origin of DNA replication in the genome of a baculovirus pathogenic for Orgyia pseudotsugata. Virology. 197, 715-725.
29. Kool M., Goldbach R.W., Vlak J.M. 1994. A putative non-hr origin of DNA replication in the HindIII-K fragment of Autographa californica nuclear polyhedrosis virus. J. Gen. Virol. 75, 3345-3352.
30. Heldens J.G.M., Broer R., Zuidema D., Goldbach R.W., Vlak J.M. 1997. Identification and functional analysis of a non-hr origin of DNA replication in the genome of Spodoptera exigua nucleopolyhedrovirus. J. Gen. Virol. 78, 1497-1506.
31. Huang J.H., Levin D.B. 1999. Identification and functional analysis of a putative non-hr origin of DNA replication from the Spodoptera littoralis type B multinucleocapsid nucleopolyhedrovirus. J. Gen. Virol. 80, 2263-2274.
32. Krell P.J. 1996. Passage effect of virus infection in insect cells. Cytotechnology. 20, 125-137.
33. Pijlman G.P., van den Born E., Martens D.E., Vlak J.M. 2001. Autographa californica baculoviruses with large genomic deletions are rapidly generated in infected insect cells. Virology. 283, 132-138.
34. Pijlman G.P., Dortmans J.C., Vermeesch A.M., Yang K., Martens D.E., Goldbach R.W., Vlak J.M. 2002. Pivotal role of the non-hr origin of DNA replication in the genesis of defective interfering baculoviruses. J. Virol. 76, 5605-5611.
35. Habib S., Hasnain S.E. 2000. Differential activity of two non-hr origins during replication of the baculovirus Autographa californica nuclear polyhedrosis virus genome. J. Virol. 74, 5182-5189.
36. Jehle J. A. 2002. The expansion of a hypervariable, non-hr ori-like region in the genome of Cryptophlebia leucotreta granulovirus provides in vivo evidence for the utilization of baculovirus non-hr oris during replication. J. Gen. Virol. 83, 2025-2034.
37. Lee H.Y., Krell P.J. 1994. Reiterated DNA fragments in defective genomes of Autographa californica nuclear polyhedrosis virus are competent for AcMNPV-dependent DNA replication. Virology. 202, 418-429.
38. Challberg M.D. 1986. A method for identifying the viral genes required for herpesvirus DNA replication. Proc. Natl. Acad. Sci. USA. 83, 9094-9098.
39. Kool M., Ahrens C.H., Goldbach R.W., Rohrmann G.F., Vlak J.M. 1994. Identification of genes involved in DNA replication of the Autographa californica baculovirus. Proc. Natl. Acad. Sci. USA. 91, 11212-11216.
40. Kool M., Voeten J.T.M., Vlak J.M. 1994. Functional mapping of regions of the Autographa californica nuclear polyhedrosis viral genome required for DNA replication. Virology. 198, 680-689.
41. Lu A., Miller L.K. 1995. The roles of eighteen baculovirus late expression factor genes in transcription and DNA replication. J. Virol. 69, 975-982.
42. Ahrens C.H., Rohrmann G.F. 1995. Identification of essential trans-acting regions required for DNA replication of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus: lef-1 is an essential replication gene. Virology. 207, 417-428.
43. Ahrens C.H., Rohrmann G.F. 1995. Replication of Orgyia pseudotsugata baculovirus DNA: ie-1 and lef-2 are essential and ie-2, p34 and op-iap are stimulatory genes. Virology. 212, 650-662.
44. Ahrens C.H., Carlson C., Rohrmann G.F. 1995. Identification, sequence and transcriptional analysis of lef-3, a gene essential for Orgyia pseudotsugata baculovirus DNA replication. Virology. 210, 372-382.
45. Rapp J.C., Wilson J.A., Miller L.K. 1998. Nineteen baculovirus open reading frames, including LEF-12, support late gene expression. J. Virol. 72, 10197-10206.
46. Mikhailov V.S., Marlyev K.A., Ataeva J.O., Kullyev P.K., Atrazhev A.M. 1986. Characterization of 3′ → 5′ exonuclease associated with DNA polymerase of silkworm nuclear polyhedrosis virus. Nucleic Acids Res. 14, 3841-3857.
47. Hang X., Guarino L.A. 1999. Purification of Autographa californica nucleopolyhedrovirus DNA polymerase from infected insect cells. J. Gen. Virol. 80, 2519-2526.
48. McDougal V.V., Guarino L.A. 1999. Autographa californica nuclear polyhedrosis virus DNA polymerase: measurements of processivity and strand displacement. J. Virol. 73, 4908-4918.
49. Huang J., Levin D.B. 2001. Expression, purification and characterization of the Spodoptera littoralis nucleopolyhedrovirus (SpliNPV) DNA polymerase and interaction with the SpliNPV non-hr origin of DNA replication. J. Gen. Virol. 82, 1767-1776.
50. Tomalski M.D., Wu J.G., Miller L.K. 1988. The location, sequence, transcription, and regulation of a baculovirus DNA polymerase gene. Virology. 167, 591-600.
51. O'Reilly D.R., Crawford A.M., Miller L.K. 1989. Viral proliferating cell nuclear antigen. Nature. 337, 606.
52. Crawford A.M., Miller L.K. 1988. Characterization of an early gene accelerating expression of late genes of the baculovirus Autographa californica nuclear polyhedrosis virus. J. Virol. 62, 2773-2781.
53. Gomi S., Majima K., Maeda S. 1999. Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus. J. Gen. Virol. 80, 1323-1337.
54. Mikhailov V.S., Marlyev L.A., Ataeva D.O., et al. 1986. Inhibitor analysis of DNA replicase (DNA polymerase α-DNA primase complex) and DNA polymerase of the Bombix mori nuclear polyhedrosis virus. Bioorgan. Khim. 12, 626-632.
55. Rice W.C., Miller L.K. 1986. Baculovirus transcription in the presence of inhibitors and in nonpermissive Drosophila cells. Virus Research. 6, 155-172.
56. Lu A., Carstens E.B. 1991. Nucleotide sequence of a gene essential for viral DNA replication in the baculovirus Autographa californica nuclear polyhedrosis virus. Virology. 181, 336-347.
57. Liu G., Carstens E.B. 1999. Site-directed mutagenesis of the AcMNPV p143 gene: effects on baculovirus DNA replication. Virology. 253, 125-136.
58. Gorbalenya A.E., Koonin E.V. 1993. Helicases: amino acid sequence comparisons and structure-function relationships. Current Opin. Struct. Biol. 3, 419-429.
59. McDougal V.V., Guarino L.A. 2000. The Autographa californica nuclear polyhedrosis virus p143 gene encodes a DNA helicase. J. Virol. 74, 5273-5279.
60. Bideshi D.K., Federici B.A. 2000. DNA-independent ATPase activity of the Trichoplusia ni granulovirus DNA helicase. J. Gen. Virol. 81, 1601-1604.
61. Laufs S., Lu A., Arrell K., Carstens E.B. 1997. Autographa californica nuclear polyhedrosis virus p143 gene product is a DNA-binding protein. Virology. 228, 98-106.
62. McDougal V.V., Guarino L.A. 2001. DNA and ATP binding activities of the baculovirus DNA helicase P143. J. Virol. 75, 7206-7209.
63. Evans J.T., Rosenblatt G.S., Leisy D.J., Rohrmann G.F. 1999. Characterization of the interaction between the baculovirus ssDNA-binding protein (LEF-3) and putative helicase (P143). J. Gen. Virol. 80, 493-500.
64. Wu Y., Carstens E.B. 1998. A baculovirus single-stranded DNA binding protein, LEF-3, mediates the nuclear localization of the putative helicase P143. Virology. 247, 32-40.
65. Maeda S., Kamita S.G., Kondo A. 1993. Host range expansion of Autographa californica nuclear polyhedrosis virus (NPV) following recombination of a 0.6-kilo-base-pair DNA fragment originating from Bombyx mori NPV. J. Virol. 67, 6234-6238.
66. Croizier G., Croizier L., Argaud O., Poudevigne D. 1994. Extension of Autographa californica nuclear polyhedrosis virus host range by interspecific replacement of a short DNA sequence in the p143 helicase gene. Proc. Natl. Acad. Sci. USA. 91, 48-52.
67. Kamita S.G., Maeda S. 1993. Inhibition of Bombyx mori nuclear polyhedrosis virus (NPV) replication by the putative DNA helicase gene of Autographa californica NPV. J. Virol. 67, 6239-6245.
68. Bideshi D.K., Federici B.A. 2000. The Trichoplusia ni granulovirus helicase is unable to support replication of Autographa californica multicapsid nucleopolyhedrovirus in cells and larvae of T-ni. J. Gen. Virol. 81, 1593-1599.
69. Guarino L.A., Summers M.D. 1986. Functional mapping of a trans-activating gene required for expression of a baculovirus delayed-early gene. J. Virol. 57, 563-571.
70. Guarino L.A., Summers M.D. 1986. Interspersed homologous DNA of Autographa californica nuclear polyhedrosis virus enhances delayed-early gene expression. J. Virol. 60, 215-223.
71. Blissard G.W., Rohrmann G.F. 1991. Baculovirus gp64 gene expression: analysis of sequences modulating immediate early transcription and transactivation by IE1. J. Virol. 65, 5820-5827.
72. Lu A., Carstens E.B. 1993. Immediate-early baculovirus genes transactivate the p143 gene promoter of Autographa californica nuclear polyhedrosis virus. Virology. 195, 710-718.
73. Rodems S.M., Friesen P.D. 1993. The hr5 transcriptional enhancer stimulates early expression from the Autographa californica nuclear polyhedrosis virus genome but is not required for virus replication. J. Virol. 67, 5776-5785.
74. Chisholm G.E., Henner D.J. 1988. Multiple early transcripts and splicing of the Autographa californica nuclear polyhedrosis virus IE-1 gene. J. Virol. 62, 3193-3200.
75. Pathakamuri J.A., Theilmann D.A. 2002. The acidic activation domain of the baculovirus transactivator IE1 contains a virus-specific domain essential for DNA replication. J. Virol. 76, 5598-5604.
76. Kovacs G.R., Choi J., Guarino L.A., Summers M.D. 1992. Functional dissection of the Autographa californica nuclear polyhedrosis virus immediate-early 1 transcriptional regulatory protein. J. Virol. 66, 7429-7437.
77. Slack J.M., Blissard G.W. 1997. Identification of two independent transcriptional activation domains in the Autographa californica multicapsid nuclear polyhedrosis virus IE1 protein. J. Virol. 71, 9579-9587.
78. Guarino L. A., Dong W. 1991. Expression of an enhancer-binding protein in insect cells transfected with the Autographa californica nuclear polyhedrosis virus IE1 gene. J. Virol. 65, 3676-3680.
79. Choi J., Guarino L.A. 1995. The baculovirus transactivator IE1 binds to viral enhancer elements in the absence of insect cell factors. J. Virol. 69, 4548-4551.
80. Leisy D.J., Rasmussen C., Kim H.-T., Rohrmann G.F. 1995. The Autographa californica nuclear polyhedrosis virus homologous region 1a: Identical sequences are essential for DNA replication activity and transcriptional enhancer function. Virology. 208, 742-752.
81. Rasmussen C., Leisy D.J., Ho P.S., Rohrmann G.F. 1996. Structure-function analysis of the Autographa californica multinucleocapsid nuclear polyhedrosis virus homologous region palindromes. Virology. 224, 235-245.
82. Rodems S.M., Friesen P.D. 1995. Transcriptional enhancer activity of hr5 requires dual-palindrome half sites that mediate binding of a dimeric form of the baculovirus transregulator IE1. J. Virol. 69, 5368-5375.
83. Rodems S.M., Pullen S.S., Friesen P.D. 1997. DNA-dependent transregulation by IE1 of Autographa californica nuclear polyhedrosis virus: IE1 domains required for transactivation and DNA binding. J. Virol. 71, 9270-9277.
84. Leisy D.J., Rohrmann G.F. 2000. The Autographa californica nucleopolyhedrovirus IE-1 protein complex has two modes of specific DNA binding. Virology. 274, 196-202.
85. Olson V.A., Wetter J.A., Friesen P.D. 2001. Oligomerization mediated by a helix-loop-helix-like domain of baculovirus ie1 is required for early promoter transactivation. J. Virol. 75, 6042-6051.
86. Afonso C.L., Tulman E.R., Lu Z., Balinsky C.A., Moser B.A., Becnel J.J., Rock D.L., Kutish G.F. 2001. Genome sequence of a baculovirus pathogenic for Culex nigripalpus. J. Virol. 75, 11157-11165.
87. Evans J.T., Leisy D.J., Rohrmann G.F. 1997. Characterization of the interaction between the baculovirus replication factors, LEF-1 and LEF-2. J. Virol. 71, 3114-3119.
88. Mikhailov V.S., Rohrmann G.F. 2002. The baculovirus replication factor LEF-1 is a DNA Primase. J. Virol. 76, 2287-2297.
89. Bocquier A.A., Liu L., Cann I.K., Komori K., Kohda D., Ishino Y. 2001. Archaeal primase: bridging the gap between RNA and DNA polymerases. Current Biol. 11, 452-456.
90. Copeland W.C., Tan X. 1995. Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis. J. Biol. Chem. 270, 3905-3913.
91. Copeland W.C., Wang T.S. 1993. Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. J. Biol. Chem. 268, 26179-26189.
92. Hang X., Dong W., Guarino L.A. 1995. The lef-3 gene of Autographa californica nuclear polyhedrosis virus encodes a single-stranded DNA-binding protein. J. Virol. 69, 3924-3928.
93. Mikhailov V.S., Mikhailova A.L., Iwanaga M., Gomi S., Maeda S. 1998. Bombyx mori nucleopolyhedrovirus encodes a DNA-binding protein capable of destabilizing duplex DNA. J. Virol. 72, 3107-3116.
94. Evans J.T., Rohrmann G.F. 1997. The baculovirus single-stranded DNA binding protein, LEF-3, forms a homotrimer in solution. J. Virol. 71, 3574-3579.
95. Mikhailov V.S. 2000. Helix-destabilizing properties of the baculovirus single-stranded DNA-binding protein (LEF-3). Virology. 270, 180-189.
96. Mikhailov V.S., Okano K., Rohrmann G.F. 2003. Baculovirus alkaline nuclease possesses a 5′ → 3′ exonuclease activity and associates with the DNA-binding protein LEF-3. J. Virol. 77.
97. Gomi S., Zhou C.E., Yih W., Majima K., Maeda S. 1997. Deletion analysis of four of eighteen late gene expression factor gene homologues of the baculovirus, BmNPV. Virology. 230, 35-47.
98. Clem R.J., Fechheimer M., Miller L.K. 1991. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science. 254, 1388-1390.
99. Clem R.J. 2001. Baculoviruses and apoptosis: the good, the bad, and the ugly. Cell Death Differ. 8, 137-143.
100. Xu G., Cirilli M., Huang Y., Rich R.L., Myszka D.G., Wu H. 2001. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature. 410, 494-497.
101. Shippam-Brett C.E., Willis L.G., Theilmann D.A. 2001. Analysis of sequences involved in IE2 transactivation of a baculovirus immediate-early gene promoter and identification of a new regulatory motif. Virus Research. 75, 13-28.
102. Chen C.J., Thiem S.M. 1997. Differential infectivity of two Autographa californica nucleopolyhedrovirus mutants on three permissive cell lines is the result of lef-7 deletion. Virology. 227, 88-95.
103. Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D. 2001. The complete sequence of the Cydia pomonella granulovirus genome. J. Gen. Virol. 82, 2531-2547.
104. Lu A., Miller L.K. 1995. Differential requirements for baculovirus late expression factor genes in two cell lines. J. Virol. 69, 6265-6272.
105. Lu A., Miller L.K. 1996. Species-specific effects of the hcf-1 gene on baculovirus virulence. J. Virol. 70, 5123-5130.
106. McLachlin J.R., Miller L.K. 1994. Identification and characterization of vlf-1, a baculovirus gene involved in very late gene expression. J. Virol. 68, 7746-7756.
107. Yang S., Miller L.K. 1998. Expression and mutational analysis of the baculovirus very late factor 1 (vlf-1) gene. Virology. 245, 99-109.
108. Yang S., Miller L.K. 1999. Activation of baculovirus very late promoters by interaction with very late factor 1. J. Virol. 73, 3404-3409.
109. Li L.L., Rohrmann G.F. 2000. Characterization of a baculovirus alkaline nuclease. J. Virol. 74, 6401-6407.
110. Bujnicki J.M., Rychlewski L. 2001. The herpesvirus alkaline exonuclease belongs to the restriction endonuclease PD-(D/E)XK superfamily: insight from molecular modeling and phylogenetic analysis. Virus Genes. 22, 219-230.
111. Aravind L., Makarova K., Koonin E. 2000. SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. Nucleic Acids Res. 28, 3417-3432.
112. Goldstein J.N., Weller S.K. 1998. In vitro processing of herpes simplex virus type 1 DNA replication intermediates by the viral alkaline nuclease, UL12. J. Virol. 72, 8772-8781.
113. Poteete A. 2001. What makes the bacteriophage lambda Red system useful for genetic engineering: molecular mechanism and biological function. FEMS Microbiol. Lett. 201, 9-14.
114. Kuzminov A. 1999. Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol. Mol. Biol. Rev. 63, 751-813.