Lowest effective single dose of diclofenac for antipyretic and analgesic effects in acute febrile sore throat

Clinical Drug Investigation

Volumn 23, Issue 4, 2003, Pages 263-271

  Gehanno, P ^a   Dreiser, R L ^e   Ionescu, E ^b,d   Gold, Morris ^c   Liu, Jiun Min ^c  

^a Otorhinolaryngology/Maxillofacial S   (France)

^b Department of Clinical Pharmacology   (Switzerland)

^c Novartis Consumer Health Inc   (United States)

^d Dept of Preclinical Development   (Switzerland)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; DICLOFENAC POTASSIUM; PARACETAMOL; PLACEBO;

ADULT; ANALGESIA; ANTIPYRETIC ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSPHAGIA; FEMALE; FEVER; FRANCE; GASTROINTESTINAL DISEASE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHARYNGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SORE THROAT; TONSILLITIS;

EID: 0037269980     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200323040-00006     Document Type: Article

References (8)

1. Keinänen-Kiukaannierni S, Similä S, Käpylä H. Antipyretic therapy: evaluation of diclofenac sodium as an antipyretic agent. Clin Ther 1980; 2: 421-7
2. Polman HA, Huijbers WA, Augusteijn R. The use of diclofenac sodium (Voltaren®) suppositories as an antipyretic in children with fever due to acute infections: a double-blind, between-patient, placebo-controlled study. J Int Med Res 1981; 9: 343-8
3. Bettini R, Grossi E, Rapazzini P, et al. Diclofenac sodium versus acetylsalicylic acid: a randomized study in febrile patients. J Int Med Res 1986; 14: 95-100
4. Schachtel BP, Fillingim JM, Thoden WR, et al. Sore throat pain in the evaluation of mild analgesics. Clin Pharmacol Ther 1988; 44: 704-11
5. Weckx LL, Ruiz JE, Duperly J, et al. Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib and diclofenac. J Intl Med Res 2002; 30 (2): 185-94
6. Schachtel BP, Thoden WR. A placebo-controlled model for assaying systemic analgesics in children. Clin Pharmacol Ther 1993; 53: 593-601
7. Grebe W, Ionescu I, Gold MS, et al. A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms. Clin Therap 2003; 25 (2): 444-59
8. Autret E, Rebout-Marty J, Henry-Launois B, et al. Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. Eur J Clin Pharmacol 1997; 51: 367-71