Effects of the β1-selective adrenergic antagonist betaxolol on electroretinography in the perfused cat eye: Effects of betaxolol on ERG in the perfused cat eye

Documenta Ophthalmologica

Volumn 106, Issue 1, 2003, Pages 37-41

  Uji, Yukitaka ^a   Kuze, Manami ^a   Matubara, Hisashi ^a   Doi, Motoaki ^a   Sasoh, Mikio ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Betaxolol; Electroretinography; Perfused cat eye

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; CALCIUM CHANNEL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

A WAVE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY PERFUSION; B WAVE; CAT; CONFERENCE PAPER; DRUG EFFECT; DRUG MECHANISM; ELECTRORETINOGRAPHY; EYE; EYE BLOOD FLOW; FLOW RATE; GLAUCOMA; NONHUMAN; PHOTOSTIMULATION; RETINA; RETINA ISCHEMIA; ANIMAL; ARTICLE; BLOOD FLOW; DOSE RESPONSE; PERFUSION; PHYSIOLOGY; RETINA BLOOD VESSEL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BETAXOLOL; CATS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRORETINOGRAPHY; PERFUSION; REGIONAL BLOOD FLOW; RETINA; RETINAL VESSELS;

EID: 0037267052     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022404630736     Document Type: Conference Paper

References (20)

1. Osborne NN, De Santis L, Bae JH, Ugarte M, Wood JPM, Nash MS, Chidlow G. Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to retina. Exp Eye Res 1999; 69: 331-42.
2. Gross RL, Hensley SH, Gao F, Wu SM. Retinal ganglion cell dysfunction induced by hypoxia and glutamate: Potential neuroprotective effects of β-blockers. Surv Ophthalmol 1999; 43(Suppl 1): 162-70.
3. Uji Y. Effects of beta blockers on blood velocity in the orbital arteries in chronic open-angle glaucoma. In: Drance, SM ed. Vascular Risk Factors and Neuroprotection in Glaucoma - Update 1996. Amsterdam/New York: Kugler Publication, 1997: 241-8.
4. Harris A, Spaeth GL, Sergott RC, Katz LI, Cantor LB, Martin BJ. Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am J Ophthalmol 1995; 120: 168-75.
5. Miyamura N, Uji Y. Effects of carteolol on the electroretinogram in the perfused cat eye. Doc Ophthalmol 1993; 84: 97-103.
6. Uji Y, Niemeyer G, Gerber U. The effects of β-adrenergic agonists on cone system in the cat eye. Doc Ophthalmol 1988; 70: 77-87.
7. Niemeyer G. Retinal research using the perfused mammalian eye. Prog Retinal Eye Res 2001; 20: 289-318.
8. Miyamura N. The characteristics of isolated arterially perfused cat eye. Mie Medical J 1993; 43: 23-31.
9. Niemeyer G, Cottier D, Resch H. Effects of buphenine(nylidrin) on the perfused mammalian eye. Graefes Arch Clin Exp Ophthalmol 1987; 225: 33-8.
10. Gerber U, Niemeyer G. β-Adrenergic antagonists modify retinal function in the perfused cat eye. Clin Vision Sci 1988; 3: 255-66.
11. Uji Y, Niemeyer G. Electrophysiological study using the perfused eye. Eye Mook (Japanese). Tokyo: Kanehara Publication, 1989; 41: 30-49.
12. Niemeyer G, Cottier D, Gerber U. Effects of β-agonists on b- and c-waves implicit for adrenergic mechanisms in cat retina. Doc Ophthalmol 1987; 66: 373-81.
13. Yabuuchi Y, Kinoshita D. Cardiovascular studies of 5-(3-tert-buthlamino-2-hydroxy)propoxyl-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent β-adrenergic blocking agent. Jpn J Pharmacol 1974; 24: 853-61.
14. Janczewski P, Boulanger C, Iqbal A, Vanhouete PM. Endothelium-dependent effects of carteolol. J Pharmacol Exp Ther 1988; 247: 590-95.
15. Hoste AM, Boels PJ, Andries LJ, Brutsaert DL, De Laey JJ. Effects of beta-antagonists on contraction of bovine retinal microarteries in vitro. Invest Ophthalmol Vis Sci 1990; 31: 1231-7.
16. De Santis L, Dahlin D, Barnes G. A role for the calcium channel blocking-like action of betaxolol for providing therapeutic benefit to glaucoma patients. In: Drance SM, ed. Update to Glaucoma, Ocular Blood Flow and Drug Treatment. Amsterdam/New York: Kugler Publication, 1995: 137-43.
17. Hoste AM, Sys SU. The relaxant action of betaxolol isolated bovine retinal microarteries. Curr Eye Res 1994; 13: 483-7.
18. 2+ entry blockers on ocular vessels. In: Drance SM, ed. Vascular Risk Factors and Neuroprotection in Glaucoma - Update 1996. Amsterdam/New York: Kugler Publication, 1997: 123-34.
19. Bose S, Piltz JR, Breton ME. Nimodipine, a centrally active calcium channel antagonist, exerts a beneficial effects on contrast sensitivity in patients with normal-tension glaucoma. Ophthalmology 1995; 102: 1236-41.
20. Sawada A, Kitazawa Y. Yamamoto T, Okabe I, Ichien K. Prevention of visual field defect progression with brovincamine in eyes with normal-tension glaucoma. Ophthalmology 1996; 103: 283-8.