Studies on metabolism of ketoprofen isopropyl ester in HaCat cells

Chinese Pharmaceutical Journal

Volumn 38, Issue 1, 2003, Pages 22-25

  Zhu, Quan gang ^a   Hu, Jin hong ^a   Fan, Guo rong ^a   Zhang, Li ^a   Sun, Hua jun ^a   Gu, Jun ^a   Mi, Qing sheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HaCaT cell; Ketoprofen; Ketoprofen isopropyl ester; Skin metabolism

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PHOSPHATES;

ESTER PRODRUG;

CELLS;

KETOPROFEN; KETOPROFEN ISOPROPYL ESTER; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL FREE SYSTEM; CELL METABOLISM; CELL VIABILITY; DRUG HYDROLYSIS; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KERATINOCYTE; MODEL; SKIN CELL;

EID: 0037266620     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Rautio J, Taipale H, Gynther J, et al. In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen [J]. J Pharm Sci, 1998, 87(12):1622.
2. Altenburger R, Kissel T. The human keratinocyte cell line HaCaT:an in vitro cell culture model for keratinocyte testosterone metabolism[J]. Pharm Res, 1999, 16(5):766.