A formal total synthesis of eleman-8β,12-olide with SmI2-induced cyclization

Synlett

Volumn , Issue 5, 2003, Pages 717-719

  Miyaoka, Hiroaki ^a   Nishiyama, Akira ^a   Nagaoka, Hiroto ^a   Yamada, Yasuji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Cyclization; Eleman 8 ,12 olide; Enantioselective synthesis; Samarium(II) iodide; Sesquiterpenoid

Indexed keywords

CYCLOHEXANE DERIVATIVE; ELEMAN 8BETA,12 OLIDE; SAMARIUM DIIODIDE; SESQUITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CHEMICAL REACTION; CYCLIZATION; DRUG SYNTHESIS; OXIDATION; STEREOCHEMISTRY; TECHNIQUE;

EID: 0037263650     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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19. Compounds 2 and 4 were prepared as shown in Scheme 4. matrix presented
20. 4. Following removal of solvent under reduced pressure, the crude product was purified by silica gel column chromatography to give 3 in 70% yield.
21. 15 as illustrated in Scheme 5. matrix presented
22. Compound 6 was prepared as indicated in Scheme 6. matrix presented
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