Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells

Chemical Research in Toxicology

Volumn 16, Issue 1, 2003, Pages 87-94

  Wichmann, Anita E ^a   Thomson, Nicole M ^a,b   Peterson, Lisa A ^a,b   Wattenberg, Elizabeth V ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; 7 METHYLGUANINE; ALKYLATING AGENT; DNA; GLUTATHIONE; METHYLNITROSOUREA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; N ACETOXYMETHYL N METHYLNITROSAMINE; N METHYL N NITROSOURETHAN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA ADDUCT; DNA METHYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; GENOTOXICITY; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TRANSFORMED; DIMETHYLNITROSAMINE; DNA; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; LUNG; METHYLNITROSOUREA; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENS; NITROSOMETHYLURETHANE; PROTEIN-SERINE-THREONINE KINASES; RATS; RESPIRATORY MUCOSA;

ANIMALIA;

EID: 0037259218     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0256026     Document Type: Article

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