Immunohistochemical detection of cytokine expression in tissue-implant response associated with TCP bioceramic implants loaded with steroid hormones

Biomedical Sciences Instrumentation

Volumn 39, Issue , 2003, Pages 541-546

  Butler Jr , Kenneth R ^a   Benghuzzi, Hamed A ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Androgens; Biocompatibility; CD 14; CD 4; Cytokine; IL 1; IL 2; IL 6; Immunohistochemistry; Steroid hormones; TCP bioceramics; Tissue implant response; TNF

Indexed keywords

DRUG PRODUCTS; GROWTH KINETICS; HORMONES; IMMUNOLOGY; IMPLANTS (SURGICAL); TISSUE; VETERINARY MEDICINE;

BIOCERAMICS;

ANIMAL CELL CULTURE;

ANDROSTANOLONE; ANDROSTENEDIONE; CALCIUM PHOSPHATE; CD14 ANTIGEN; CD4 ANTIGEN; COLLAGEN; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; STEROID HORMONE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; CELL COMPOSITION; CERAMIC PROSTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DELIVERY SYSTEM; FIBROBLAST; IMMUNOHISTOCHEMISTRY; MALE; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PROTEIN EXPRESSION; RAT; SOFT TISSUE; THICKNESS; VASCULARIZATION;

ANDROGENS; ANDROSTENEDIONE; ANIMALS; CALCIUM PHOSPHATES; CYTOKINES; DIHYDROTESTOSTERONE; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FIBROSIS; FOREIGN-BODY REACTION; HORMONES; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; TESTOSTERONE;

EID: 0037258264     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (23)

1. Bajpai, P.K. & Benghuzzi H.A. (1988). Ceramic systems for long term delivery of chemicals and biologicals. Journal of Biomedical Material Resources, 22, 1245-1266.
2. Benghuzzi, H. & England, B. (1995). Long-term sustained delivery of androgens by means of TCPL devices and the effect on high-density lipoprotein in castrated rams. Biomedical Sciences Instrumentation, 31, 165-70.
3. Benghuzzi, H. Bajpai, P., & England, B. (1994a). Pathophysiological evaluation associated with sustained delivery of danazol and dihydrotestosterone in adult male rodents. Biomedical Sciences Instrumentation, 30, 197-204.
4. Benghuzzi, H.A., England, B. & Baipai, P.K. (1992a) Controlled release of hydrophilic compounds by resorbable and biodegradable ceramic drug delivery devices. Biomedical Sciences Instrumentation, 28, 179-182.
5. Anderson, J.M. (1994). The extracellular matrix and biomaterials. R.S. Greco (Ed.). Implantation Biology - The Host Response To Biomedical Devices (pp. 113-130). Boca Raton: CRC Press.
6. Anderson, J.M. & Miller, K.M. (1984). Biomaterial biocompatability and the macrophage. Biomaterials, 5, 5-10.
7. Anderson, J.M. (1999). Soft tissue histology. A. von Recum (Ed.), Handbook of Biomaterial Evaluation (pp.585-586). Pennsylvania: Taylor & Francis.
8. Coleman, D.L., King, R.N., & Andrade, J.D. (1974a). The foreign body reaction - an experimental protocol. Journal of Biomedical Materials Resources, 5, 65-76.
9. Coleman, D.L., King, R.N. & Andrade, J.D. (1974b). The foreign body reaction: a chronic inflammatory response. Journal of Biomedical Materials Resources, 8, 191-211.
10. Salthouse, T.N. (1999). Evaluation by histochemical and quantitative microscopy. Handbook of Biomaterials Evaluation (pp. 631-640). Pennsylvania: Taylor & Francis.
11. Salthouse, T.N. (1981). Enzyme Histochemistry of the cellular response to implants. Fundamental Aspects of Biocompatability (pp. 233-237). Boca Raton: CRC Press.
12. Butler, K., Benghuzzi, H.A., Tucci, M., & Cason, Z. (1997a). A comparison of fibrous tissue formation surrounding intraperitoneal and subcutaneous implantation of ALCAP, HA, and TCP ceramic devices. Biomedical Sciences Instrumentation, 34, 18-23.
13. Butler, K., Puckett, A., & Benghuzzi, H.A. (1999). Quantitative analysis of the cellular components of the fibrous tissue matrix surrounding ALCAP, HA, and TCP bioceramics. Biomedical Sciences Instrumentation, 35, 267-272.
14. Butler, K. (1999). Tissue implant reaction associated with the subcutaneous and intraperitoneal implantation of ALCAP, HA, and TCP bioceramics using adult male rats as a model. (Master's thesis, University of Mississippi Medical Center, 1999).
15. Coleman, T.N., Benghuzzi, H., Tucci, M., & Hughes, J. (2000). Morphological and biochemical evaluation of RAW 264.7 macrophages after acute and chronic administration of DHEA AED. Biomedical Sciences Instrumentation, 36, 355-360.
16. Shanbhag, A.S., Macaulay, W., Stefanovic-Racic, M., & Rubash, H.E. (1998). Nitric oxide release by macrophages in response to particular wear debris. Journal of Biomedical Material Resources, 41(3), 497-503.
17. D'Agostino, P., Milano, S., Barbera, C., Di Bellam, G., La Rosa M., Ferlazzo, V., Farruggio, R., Miceli, D.M., Miele, M., Castagnetta, L., & Cillari, E. (1999). Sex hormones modulate inflammatory mediators produced by macrophages. Annals of the New York Academy of Science, 876, 426-9.
18. Butler, K., Benghuzzi, H.A., & Puckett, A. (2001). Cytological evaluation of the tissue-implant reaction associated with S/C and I/P implantation of the ALCAP and HA bioceramics. Pathology Research and Practice, 197, 29-39.
19. Friedl, R. Brunner, M., Moeslinger, T., & Spieckermann, P.G. (2000). Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages. Life Science, 68(4), 417-429.Hughes, T.K., Rady, P.L., & Smith, E.M. (1998). Potential for the effects of anabolic steriod abuse in the immune and neuroendocrine axis. Journal of Neuroimmunology, 83(1-2), 162-167.
20. Friedl, R. Brunner, M., Moeslinger, T., & Spieckermann, P.G. (2000). Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages. Life Science, 68(4), 417-429.Hughes, T.K., Rady, P.L., & Smith, E.M. (1998). Potential for the effects of anabolic steriod abuse in the immune and neuroendocrine axis. Journal of Neuroimmunology, 83(1-2), 162-167.
21. Spath-Schwalbe, E., Schrezenmeier, H., Bornstein, S., Burger, K., Porzsolt, R., & Born, J. (1996). Endocrine effects of recombinant interleukin 6 in man. Neuroendocrinology, 63(3), 237-43.
22. Hughes, T.K., Rady, P.L., & Smith, E.M. (1998). Potential for the effects of anabolic steriod abuse in the immune and neuroendocrine axis. Journal of Neuroimmunology, 83(1-2), 162-167.
23. Papadopoulos, A.D. & Wardlaw, S.L. (2000). Testosterone suppresses the response of the hypothalamic-pituitary-adrenal axis to interleukin-6. Neuroimmunomodulation, 8(1), 39-44.