A selective and sensitive method for quantitation of lysergic acid diethylamide (LSD) in whole blood by gas chromatography-ion trap tandem mass spectrometry

Journal of Analytical Toxicology

Volumn 27, Issue 1, 2003, Pages 24-29

  Libong, Danielle ^a   Bouchonnet, Stéphane ^a   Ricordel, Ivan ^b  

^a ECOLE POLYTECHNIQUE   (France)

^b Laboratoire de Toxicologie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; BLOOD EXTRACT; LYSERGIC ACID; LYSERGIDE; REAGENT;

ANALYTICAL EQUIPMENT; ARTICLE; BLOOD SAMPLING; DECOMPOSITION; DRUG BLOOD LEVEL; GAS CHROMATOGRAPHY; HUMAN; IONIZATION; LINEAR SYSTEM; MASS SPECTROMETRY; QUANTITATIVE ASSAY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; STANDARD; TOXICOKINETICS;

EID: 0037253602     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/27.1.24     Document Type: Article

References (16)

1. D.G. Upshall and D.G. Wailling. The determination of LSD in human plasma following oral administration. Clin. Chim. Acta 36: 67-73 (1972).
2. H.K. Lim, D. Andrenyak, P. Francom, R.L. Foltz, and R.T. Jones. Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance capture ionization mass spectrometry. Anal. Chem. 60: 1420-1425 (1988).
3. D.I. Papac and R.L. Foltz. Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J. Anal. Toxicol. 14: 189-190 (1990).
4. J.T. Cody and S. Valtier. Immunoassay analysis of lysergic acid diethylamide. J. Anal. Toxicol. 21: 459-464 (1997).
5. A.H.B. Wu, X.Y. Feng, A. Pajor, T.G. Gornet, S.S. Wong, E. Forte, and J. Brown. Detection and interpretation of lysergic acid diethylamide results by immunoassay screening of urine in various testing groups. J. Anal. Toxicol. 21: 181-184 (1997).
6. N.P. Cassels and D.H. Craston. The effects of commonly used adulterants on the detection of spiked LSD by an enzyme immunoassay. Sci. Justice 38(2): 109-117 (1998).
7. A.J. McNally, K. Goc-Szkutnicka, Z. Li, I. Pilcher, S. Polakowski, and S.J. Salamone. An online immunoassay for LSD: comparison with GC-MS and the Abuscreen® RIA. J. Anal. Toxicol. 20: 404-408 (1996).
8. Z. Li, K. Goc-Szkutnicka, A.J. McNally, I. Pilcher, S. Polakowski, S. Vitone, R.S. Wu, and S.J. Salamone. New synthesis and characterization of (+)-lysergic acid diethylamide (LSD) derivatives and the development of a microparticle-based immunoassay for the detection of LSD and its metabolites. Bioconjugate Chem. 8: 896-905 (1997).
9. S. Kerrigan and D.E. Brooks. Immunochemical extraction and detection of LSD in whole blood. J. Immunol. Methods 224: 11-18 (1999).
10. C.C. Nelson and R.L. Foltz. Determination of lysergic acid diethylamide (LSD), iso-LSD and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry. Anal. Chem. 64: 1578-1585 (1992).
11. J.H. Sklerov, K.S. Kalasinsky, and C.A. Ehorn. Detection of lysergic acid diethylamide (LSD) in urine by gas chromatography-ion trap tandem mass spectrometry. J. Anal. Toxicol. 23: 474-478 (1999).
12. M.F. Sauvage, P. Marquet, S. Ragot, F. Lachatre, J.L. Dupuy, and G. Lachatre. Determination of LSD and three of its metabolites or isomers in serum and blood samples by LC-ES-MS. Toxicorama 10(2): 73-79 (1998).
13. H. Hoja, P. Marquet, P. Verneuil, H. Lotfi, J.L. Dupuy, and G. Lachatre. Determination of LSD and N-demethyl-LSD in urine by liquid chromatography coupled to electrospray ionization mass spectrometry. J. Chromatogr. B 692(2): 329-335 (1997).
14. T. Cougnard, C. Charlier, and G. Plomteux. Ultra-rapid determination of urinary LSD and nor-LSD by liquid chromatography-mass spectrometry. Toxicorama 11(2): 99-102 (1999).
15. Bond Elut Certify Applications Book. Varian S. A., Les Ulis, France.
16. R.E. March. An introduction to quadrupole ion trap mass spectrometry. J. Mass Spectrom. 32: 351-369 (1997).