Microfluidic chip-based method for genotyping microsatellites, VNTRs and insertion/deletion polymorphisms

Clinical Biochemistry

Volumn 36, Issue 1, 2003, Pages 35-40

  Sohni, Youvraj R ^a   Burke, James P ^c   Dyck, Peter J ^d   O'Kane, Dennis J ^a,b  

^a Translational Genomics Center   (United States)

^b Departments of Nuclear Medicine   (United States)

^c Health Sciences Research   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Genotyping; Microfluidic; Microsatellites; VNTRs

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DNA FRAGMENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ALLELE; AMPLICON; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE DELETION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; ISCHEMIC HEART DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PRIORITY JOURNAL; PROMOTER REGION; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0037245580     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(02)00420-4     Document Type: Article

References (18)

1. Bousse L., Cohen C., Nikiforov T., et al. Electrokinetically controlled microfluidic analysis systems. Annu Rev Biophys Biomol Struct. 29:2000;155-181.
2. Ehrlich D.J., Matsudaira P. Microfluidic devices for DNA analysis. TIBTECH. 17:1999;315-319.
3. Weigl B.H., Yager P. Microfluidic diffusion-based separation and detection. Science. 283:2001;346-347.
4. McCaman M.T., Murakami P., Pungor E. Jr, Hahnenberger K.M., Hancock W.S. Analysis of recombinant adenoviruses using an integrated microfluidic chip-based system. Anal Biochem. 291:2001;262-268.
5. Warpeha K.M., Xu W., Liu L., et al. Genotyping and functional analysis of a polymorphic (CCTTT)n repeat of NOS2A in diabetic retinopathy. The FASEB J. 13:1999;1825-1832.
6. Xu W., Humphries S., Tomita M., et al. Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations Assessment of the NOS2A gene and predisposition to infectious disease. NITRIC OXIDE: Biology and Chemistry. 4:2000;379-383.
7. Gonzalez-Ordonez A.J., Fernandez Carreira J.M., Gonzalez Franco A., et al. Two expressive polymorphisms on the endothelial nitric oxide synthase gene (intron 4, 27 bp repeat and -786 T/C) and the venous thromboembolism. Thrombosis Research. 99:2000;563-566.
8. Pulkkinen A., Viitanen L., Kareinen A., Lehto S., Vauhkonen I., Laakso M. Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary disease. J Mol Med. 78:2000;372-379.
9. Wang X.L., Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metabol. 70:2000;241-251.
10. Zanchi A., Moczulski D., Hanna L., Wantman M., Warram J.H., Krolewski A.S. Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney International. 57:2000;405-413.
11. Cambien F., Poirier O., Lecerf L., et al. Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk factor for myocardial infarction. Nature. 359:1992;641-644.
12. Nakahara K., Matsushita S., Matsuoka H., et al. Insertion/Deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight. Circulation. 101:2000;148-154.
13. Nakano Y., Oshima T., Hiraga H., Matsuura H., Kajiyama G., Kambe M. DD genotype of the angiotensin I-converting enzyme gene is a risk factor for early onset essential hypertension in Japanese patients. The J Lab Med. 131:1998;502-506.
14. Prasad A., Narayanan S., Waclawiw M.A., Epstein N., Quyyumi A.A. The insertion/deletion polymorphism of the angiotensin converting enzyme gene determines coronary vascular tone and nitric oxide activity. J Am Coll Cardiol. 36:2000;1579-1586.
15. Dyck P.J., Kratz K.M., Lehman K.A., et al. The Rochester Diabetic Neuropathy Study Design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. Neurology. 41:1991;799-807.
16. Dyck P.J., Kratz K.M., Karnes J.L., et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort The Rochester Diabetic Neuropathy Study. Neurology. 43:1993;817-824.
17. Dyck P.J., Davies J.L., Wilson D.M., et al. Risk factors for severity of diabetic polyneuropathy. Diabetes Care. 22:1999;1479-1486.
18. Xu W., Liu L., Emson P.C., Harrington C.R., Charles I.G. Evolution of a homopurine-homopyridine pentanucleotide repeat sequence upstream of the human inducible nitric oxide synthase gene. Gene. 204:2000;165-170.