A role for overdominant selection in phenylketonuria? Evidence from molecular data

Human Mutation

Volumn 21, Issue 4, 2003, Pages 394-397

  Krawczak, Michael ^a   Zschocke, Johannes ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Heterozygote advantage; Mutation analysis; Overdominant selection; PAH; Phenylalanine hydroxylase; Phenylketonuria; PKU; Population

Indexed keywords

PHENYLALANINE 4 MONOOXYGENASE;

AMINO ACID SEQUENCE; DOMINANT INHERITANCE; EUROPE; GENE MUTATION; GENETIC SELECTION; HETEROSIS; HETEROZYGOTE; HUMAN; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENYLKETONURIA; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL; REVIEW;

EVIDENCE-BASED MEDICINE; GENES, DOMINANT; GENETICS, POPULATION; HUMANS; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS; SELECTION (GENETICS);

EID: 0037242864     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.10205     Document Type: Review

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