The target of therapies: Pathophysiology of gastroesophageal reflux disease

Gastrointestinal Endoscopy Clinics of North America

Volumn 13, Issue 1, 2003, Pages 1-17

  Kahrilas, Peter J ^a   Pandolfino, John E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ARGININE; BARBITURIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CISAPRIDE; DIAZEPAM; DOMPERIDONE; METOCLOPRAMIDE; MORPHINE DERIVATIVE; NITRATE; PETHIDINE; PROSTAGLANDIN F2 ALPHA; SEROTONIN 1 RECEPTOR; SUMATRIPTAN; THEOPHYLLINE DERIVATIVE;

DRUG ACTIVITY; DYSPHAGIA; GASTROESOPHAGEAL REFLUX; HUMAN; LOWER ESOPHAGUS SPHINCTER PRESSURE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0037242411     PISSN: 10525157     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1052-5157(02)00103-4     Document Type: Review

References (36)

1. Kahrilas PJ, Lin S, Chen J, et al. The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut 1999;44:476-82.
2. Dent J, Dodds WJ, Friedman RH, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980;65:256-67.
3. Goyal RK, Rattan S. Genesis of basal sphincter pressure: effect of tetrodotoxin on lower esophageal sphincter pressure in opossum in vivo. Gastroenterology 1976;71:62-7.
4. Goyal RK, Rattan S. Nature of the vagal inhibitory innervation to the lower esophageal sphincter. J Clin Invest 1975;55:1119-26.
5. Richards WG, Sugarbaker DJ. Neuronal control of esophageal function. Chest Surg Clin N Am 1995;5:157-71.
6. Yamato S, Saha JK, Goyal RK. Role of nitric oxide in lower esophageal sphincter relaxation to swallowing. Life Sci 1992;50:1263-72.
7. Liebermann-Meffert D, Allgower M, Schmid P, et al. Muscular equivalent of the lower esophageal sphincter. Gastroenterology 1979;76:31-8.
8. Kahrilas PJ. Anatomy and physiology of the gastroesophageal junction. Gastroenterol Clin North Am 1997;26:467-86.
9. Hill LD, Kozarek RA, Kraemer SJ, et al. The gastroesophageal flap valve: in vitro and in vivo observations. Gastrointest Endosc 1996;44:541-7.
10. Thor KB, Hill LD, Mercer DD, et al. Reappraisal of the flap valve mechanism in the gastroesophageal junction. A study of a new valvuloplasty procedure in cadavers. Acta Chir Scand 1987;153:25-8.
11. Mittal RK, Balaban DH. The esophagogastric junction. N Engl J Med 1997;336:924-32.
12. Pandolfino JE, Kahrilas PJ. Esophagel motility abnormalities in Barrett's esophagus. In: Sharma P, Sampliner RE, editors. Barrett's esophagus and esophageal adenocarcinoma. Malden: Blackwell Science; 2001. p. 35-44.
13. Altschuler SM, Boyle JT, Nixon TE, et al. Simultaneous reflex inhibition of lower esophageal sphincter and crural diaphragm in cats. Am J Physiol 1985;249:G586-91.
14. De Troyer A, Sampson M, Sigrist S, et al. Action of costal and crural parts of the diaphragm on the rib cage in dog. J Appl Physiol 1982;53:30-9.
15. Mittal RK, Fisher M, McCallum RW, et al. Human lower esophageal sphincter pressure response to increased intra-abdominal pressure. Am J Physiol 1990;258:G624-30.
16. Klein WA, Parkman HP, Dempsey DT, et al. Sphincter-like thoracoabdominal high pressure zone after esophagogastrectomy. Gastroenterology 1993;105:1362-9.
17. van Herwaarden MA, Samsom M, Smout AJ. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000;119:1439-46.
18. Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995;268:G128-33.
19. Mittal RK, Holloway RH, Penagini R, et al. Transient lower esophageal sphincter relaxation. Gastroenterology 1995;109:601-10.
20. Kahrilas PJ. Cigarette smoking and gastroesophageal reflux disease. Dig Dis 1992;10:61-71.
21. Sifrim D, Tack J, Lerut T, et al. Transient lower esophageal sphincter relaxations and esophageal body muscular contractile response in reflux esophagitis. Dig Dis Sci 2000;45:1293-300.
22. Wyman JB, Dent J, Heddle R, et al. Control of belching by the lower oesophageal sphincter. Gut 1990;31:639-46.
23. Kahrilas PJ, Shi G, Manka M, et al. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology 2000;118:688-95.
24. Sloan S, Rademaker AW, Kahrilas PJ. Determinants of gastroesophageal junction incompetence: hiatal hernia, lower esophageal sphincter, or both? Ann Intern Med 1992;117:977-82.
25. Dent J, Dodds WJ, Hogan WJ, et al. Factors that influence induction of gastroesophageal reflux in normal human subjects. Dig Dis Sci 1988;33:270-5.
26. Kahrilas PJ, Dodds WJ, Hogan WJ, et al. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 1986;91:897-904.
27. Mittal RK, Rochester DF, McCallum RW. Effect of the diaphragmatic contraction on lower oesophageal sphincter pressure in man. Gut 1987;28:1564-8.
28. Marchand P. The surgery for hiatus hernia: is vagotomy rational? S Afr Med J 1970;44:35-9.
29. Michelson E, Siegel C. The role of the phrenico-esophageal ligament in the lower esophageal sphincter. Surg Gynecol Obstet 1964;118:1291-4.
30. Kahrilas PJ, Lin S, Manka M, et al. Esophagogastric junction pressure topography after fundoplication. Surgery 2000;127:200-8.
31. Stein HJ, DeMeester TR, Naspetti R, et al. Three-dimensional imaging of the lower esophageal sphincter in gastroesophageal reflux disease. Ann Surg 1991;214:374-83.
32. Contractor QQ, Akhtar SS, Contractor TQ. Endoscopic esophagitis and gastroesophageal flap valve. J Clin Gastroenterol 1999;28:233-7.
33. Pandolfino JE, Shi G, Manka M, et al. EGJ opening with hiatal hernia: lower pressure threshold, wider diameter. Gastroenterology 2000;118:A860.
34. Curry J, Shi G, Pandolfino JE, et al. Mechanical characteristics of the EGJ after fundoplication compared to normal subjects and GERD patients. Gastroenterology 2001;120:A112.
35. Pandolfino JE, Shi G, Curry J, et al. Esophagogastric junction distensibility: A factor contributing to sphincter incompetence. Am J Physiol Gastrointest Liver Physiol 2002;282:G1052-8.
36. van Herwaarden MA, Samsom M, Smout AJ. Prolonged manometric recordings of oesophagus and lower oesophageal sphincter in achalasia patients. Gut 2001;49:813-21.