Novel Osteoinductive Biomimetic Scaffolds Stimulate Human Osteoprogenitor Activity—Implications for Skeletal Repair

Connective Tissue Research

Volumn 44, Issue 1, 2003, Pages 312-317

  Yang, X B ^a   Green, D W ^a   Roach, H I ^a   Clarke, N M P ^a   Anderson, H C ^b   Howdle, S M ^c   Shakesheff, K M ^c   Oreffo, R O C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Biodegradable Polymer; Bone Marrow; Osteoprogenitor; Plga; Poly( lactic co Glycolic Acid); Tissue Engineering

Indexed keywords

ALKALINE PHOSPHATASE; CELL EXTRACT; OSTEOBLAST STIMULATING FACTOR 1; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BIOMIMETICS; BONE CELL; BONE DEVELOPMENT; BONE REGENERATION; BONE REMODELING; CELL ACTIVITY; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL MEMBRANE POTENTIAL; CELL MIGRATION; CHEMOTAXIS; CLINICAL ARTICLE; COLONY FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MUSCULOSKELETAL DISEASE; OSSIFICATION; PROTEIN FUNCTION; STEM CELL; STRUCTURE ACTIVITY RELATION;

AGED; AGED, 80 AND OVER; ALKALINE PHOSPHATASE; BIOCOMPATIBLE MATERIALS; BONE MARROW CELLS; CALCIFICATION, PHYSIOLOGIC; CARRIER PROTEINS; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LACTIC ACID; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; OSTEOGENESIS; POLYGLYCOLIC ACID; POLYMERS; TISSUE ENGINEERING;

EID: 0037240959     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200390181834     Document Type: Article

References (37)

1. Oreffo, R.O., and Triffitt, J.T. (1999). Future potentials for us- ing osteogenic stem cells and biomaterials in orthopedics. Bone 25: 5S–9S.
2. Bruder, S.P., Jaiswal, N., Ricalton, N.S., Mosca, J.D., Kraus, K.H., and Kadiyala, S. (1998). Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin. Orthop. S247 – S256.
3. Burwell, R.G. (1994). History of bone grafting and bone substitutes with special reference to osteogenic induction. In Bone Grafts, Derivatives and Substitutes, M.R. Urist and R.G. Burwell (eds.), pp. 3 – 102. (Oxford, Butterworth-Heinemann Ltd).
4. Chaput, C., Selmani, A., and Rivard, C.H. (1996). Artificial scaffolding materials for tissue extracellular matrix repair. Curr. Opin. Orth. 7: 62 – 68.
5. Crane, G.M., Ishaug, S.L., and Mikos, A.G. (1995). Bone tissue engineer- ing. Nat. Med. 1: 1322 – 1324.
6. Hollinger, J. (1993). Strategies for regenerating bone of the craniofacial complex. Bone 14: 575 – 580.
7. Langer, R., and Vacanti, J.P. (1993). Tissue Engineering. Science 260: 920 – 926.
8. Putnam, A.J., and Mooney, D.J. (1996). Tissue engineering using synthetic extracellular matrices. Nat. Med. 2: 824 – 826.
9. Aubin, J.E., and Liu, F. (1996). The osteoblast lineage. In Principles of Bone Biology, J. Bilizekian, L. Raisz, and G. Rodan (eds.), pp. 39 – 50. (San Diego, Academic Press).
10. Friedenstein, A.J. (1995). Marrow stromal fibroblasts. Calcif. Tiss. Int. 56: S17.
11. Friedenstein, A.J., Chailakhyan, R.K., and Gerasimov, U.V. (1987). Bone marrow osteogenic stem cells. In vitro cultivation and transplantation in diffusion chambers. Cell Tiss. Kinet. 20: 263 – 272.
12. Goshima, J., Goldberg, V.M., and Caplan, A.I. (1991). The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin. Orthop. 262: 298 – 311.
13. Gundle, R., Joyner, C.J., and Triffitt, J.T. (1993). Human bone tissue formation in diffusion chamber culture in vivo by bone- derived cells and marrow stromal fibroblastic cells. Bone 16: 597 – 601.
14. Owen, M. (1988). Marrow stromal stem cells. J. Cell Sci. 10 (Suppl.): 63 – 76.
15. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284: 143 – 147.
16. Horisaka, Y., Okamoto, Y., Matsumoto, N., Yoshimura, Y., Kawada, J., Yamashita, K., and Tomomichi, T. (1991). Subperiosteal implantation of bone morphogenetic protein adsorbed to hydroxyapatite. Clin. Orthop. 268: 303 – 312.
17. Ishaug, S.L., Crane, G.M., Miller, M.J., Yasko, A.W., Yaszemski, M.J., and Mikos, A.G. (1997). Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J. Biomed. Mater. Res. 36: 17 – 28.
18. Doll, B.A., Towle, H.J., Hollinger, J.O., Reddi, A.H., and Mellonig, J.T. (1990). The osteogenic potential of two composite graft systems using osteogenin. J. Periodontol. 61: 745 – 750.
19. Ohgushi, H., Goldberg, V.M., and Caplan, A.I. (1989). Heterotopic os- teogenesis in porous ceramics induced by marrow cells. J. Orthop. Res. 7: 568 – 578.
20. Yasko, A.W., Lane, J.M., Fellinger, E.J., Rosen, V., Wozney, J.M., and Wang, E.A. (1992). The healing of segmental bone defects, induced by re- combinant human bone morphogenetic protein (rhbmp-2): A radiographic, histological and biochemical study in rats. J. Bone Joint Surg. 74a: 659 – 670.
21. Freed, L.E., Vunjak-Novakovic, G., Biron, R.J., Eagles, D.B., Lesnoy, D.C., Barlow, S.K., and Langer, R. (1994). Biodegradable polymer scaffolds for tissue engineering. Bio/Tech. 12: 689 – 693.
22. Patel, N., Padera, R., Sanders, G.H., Cannizzaro, S.M., Davies, M.C., Langer, R., Roberts, C.J., Tendler, S.J., Williams, P.M., and Shakesheff, K.M. (1998). Spatially controlled cell engineering on biodegradable poly- mer surfaces. FASEB J. 12: 1447 – 1454.
23. Peter, S.J., Miller, M.J., Yasko, A.W., Yaszemski, M.J., and Mikos, A.G. (1998). Polymer concepts in tissue engineering. J. Biomed. Mater. Res. 37: 422 – 427.
24. Quirk, R.A., Davies, M.C., Tendler, S.J.B., and Shakesheff, K.M. (2000). Surface engineering of poly(lactic acid) by entrapment of modifying species. Macromolecules 33: 158 – 260.
25. Wozney J.M., and Rosen, V. (1998). Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin. Orthop. 346: 26 – 37.
26. Urist, M.R. (1965). Bone formation by autoinduction. Science 150: 893 – 899.
27. Wozney, J.M., Rosen, V., Celeste, A.J., Mitsock, L.M., Whitters, M.J., Kriz, R.W., Hewick, R.M., and Wang, E.A. (1988). Novel regulators of bone formation: Molecular clones and activities. Science 242: 1528 – 1534.
28. Daluiski, A., Engstrand, T., Bahamonde, M.E., Gamer, L.W., Agius, E., Stevenson, S.L., Cox, K., Rosen, V., and Lyons, K.M. (2001). Bone mor- phogenetic protein-3 is a negative regulator of bone density. Nat. Genet. 27 (1): 84 – 88.
29. Anderson, H.C., Gurley, D.J., Hsu, H.H.T., Aguilera, X.M., Davis, L.S., and Moylan, P.E. (1999). Secretion of a bone-inducing agent (BIA) by cultured SAOS-2 human osteosarcoma cells. J. Musculoskel. Res. 3: 39 – 49.
30. Anderson, H.C., Hsu, H.H.T., Raval, P., Hunt, T.R., Schwappach, J.R., Morris, D.C., and Schneider, D.J. (1995). The mechanism of bone induc- tion and bone healing by human osteosarcoma cell extracts. Clin. Orth. Rel. Res. 313: 129 – 134.
31. Anderson, H.C., Reynolds, P.R., Hsu, H.H.T., Missana, L., Masuhara, K., Moylan, P.E., and Roach, H.I. (2002). Selective synthesis of bone morphogenetic proteins-1,3,4 and bone sialoprotein may be important for Osteoinduction by Saos-2 cells. J. Bone Min. Metab. 20: 73 – 82.
32. Imai, S., Kaksonen, M., Raulo, E., Kinnunen, T., Fages, C., Meng, X., Lakso, M., and Raulo, H. (1998). Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth- associated molecule (HB-GAM). J. Cell Biol. 143: 1113 – 1128.
33. Masuda, H., Tsujimura, A., Yoshioka, M., Arai, Y., Kuboki, Y., Mukai, T., Nakamura, T., Tsuji, H., Nakagawa, M., and Hashimoto-Gotoh, T. (1997). Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem. Biophys. Res. Comm. 238 (2): 528 – 533.
34. Oreffo, R.O., Virdi, A.S., and Triffitt, J.T. (2000). Retroviral marking of human bone marrow fibroblasts—in vitro expansion and homing to skele- tal sites in vivo. J. Cell Physiol. 186: 201 – 209.
35. Howdle, S.M., Watson, M.S., Whitaker, M.J., Popov, V.K., Davies, M.C., Mandel, F.S., Wang, J.D., and Shakesheff, K.M. (2001). Supercritical fluid mixing: Preparation of thermally sensitive polymer composites containing bioactive materials. Chem. Comm. 1: 109 – 110.
36. Yang, X.B., Roach, H.I., Clarke, N.M.P., Howdle, S.M., Quirk, R., Shakesheff, K.M., and Oreffo, R.O.C. (2001). Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after sur- face modification. Bone 29: 523 – 531.
37. de Groot, K. (1998). Carriers that concentrate native bone morphogenetic protein in vivo. Tiss. Eng. 4: 337 – 341.