Cell type-dependent activation of 5-lipoxygenase by arachidonic acid

Journal of Leukocyte Biology

Volumn 73, Issue 1, 2003, Pages 191-200

  Bürkert, Eva ^c   Szellas, Dagmar ^c   Rådmark, Olof ^a   Steinhilber, Dieter ^c   Werz, Oliver ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GOETHE UNIVERSITY   (Germany)

^c NONE

Author keywords

Ca2+; Leukotriene; MAP kinase

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; LEUKOTRIENE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; MAST CELL LEUKEMIA; NEUTROPHIL; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; BASOPHILS; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HELA CELLS; HUMANS; KINETICS; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; SIGANUS;

EID: 0037238904     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0702354     Document Type: Article

References (42)

1. Rådmark, O. (2000) The molecular biology and regulation of 5-lipoxygenase. Am. J. Respir. Crit. Care Med. 161, S11-S15.
2. Samuelsson, B. (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575.
3. Peters-Golden, M., Brock, T. G. (2000) Intracellular compartmentalization of leukotriene biosynthesis. Am. J. Respir. Crit. Care Med. 161, S36-S40.
4. Gijon, M. A., Spencer, D. M., Kaiser, A. L., Leslie, C. C. (1999) Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J. Cell Biol. 145, 1219-1232.
5. Chen, X. S., Funk, C. D. (2001) The N-terminal "β-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation. J. Biol. Chem. 276, 811-818.
6. Hammarberg, T., Provost, P., Persson, B., Rådmark, O. (2000) The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J. Biol. Chem. 275, 38787-38793.
7. Kulkarni, S., Das, S., Funk, C. D., Murray, D., Cho, W. (2002) A molecular basis of specific subcellular localization of the C2-like domain of 5-lipoxygenase. J. Biol. Chem. 277, 13167-13174.
8. Werz, O., Buerkert, E., Samuelsson, B., Rådmark, O., Steinhilber, D. (2002) Activation of 5-lipoxygenase by cell stress is calcium-independent in human polymorphonuclear leukocytes. Blood 99, 1044-1052.
9. Naccache, P. H., McColl, S. R., Caon, A. C., Borgeat, P. (1989) Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action. Br. J. Pharmacol. 97, 461-468.
10. Schatz-Munding, M., Hatzelmann, A., Ullrich, V. (1991) The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes. Eur. J. Biochem. 197, 487-493.
11. Surette, M. E., Krump, E., Picard, S., Borgeat, P. (1999) Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4). Mol. Pharmacol. 56, 1055-1062.
12. Werz, O., Szellas, D., Steinhilber, D., Samuelsson, B., Rådmark, O. (2002) Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPKAP kinase-2. J. Biol. Chem. 277, 14793-14800.
13. Werz, O., Buerkert, E., Fischer, L., Szellas, D., Dishart, D., Rådmark, O., Samuelsson, B., Steinhilber, D. (2002) Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product synthesis in leukocytes. FASEB J. 16, 1441-1443.
14. Werz, O., Klemm, J., Samuelsson, B., Rådmark, O. (2000) 5-Lipoxygenase is phosphorylated by p38 kinase dependent MAPKAP kinases. Proc. Natl. Acad. Sci. USA 97, 5261-5266.
15. Werz, O., Klemm, J., Rådmark, O., Samuelsson, B. (2001) p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. J. Leukoc. Biol. 70, 830-838.
16. Werz, O., Klemm, J., Samuelsson, B., Rådmark, O. (2001) Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. Blood 97, 2487-2495.
17. Hii, C. S., Huang, Z. H., Bilney, A., Costabile, M., Murray, A. W., Rathjen, D. A., Der, C. J., Ferrante, A. (1998) Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases. J. Biol. Chem. 273, 19277-19282.
18. Khan, W. A., Blobe, G. C., Hannun, Y. A. (1995) Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell. Signal. 7, 171-184.
19. Hii, C. S., Moghadammi, N., Dunbar, A., Ferrante, A. (2001) Activation of the phosphatidylinositol 3-kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells: involvement of the ErbB receptor family. J. Biol. Chem. 276, 27246-27255.
20. Cui, X. L., Douglas, J. G. (1997) Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells. Proc. Natl. Acad. Sci. USA 94, 3771-3776.
21. Hii, C. S., Ferrante, A., Edwards, Y. S., Huang, Z. H., Hartfield, P. J., Rathjen, D. A., Poulos, A., Murray, A. W. (1995) Activation of mitogen-activated protein kinase by arachidonic acid in rat liver epithelial WB cells by a protein kinase C-dependent mechanism. J. Biol. Chem. 270, 4201-4204.
22. Paine, E., Palmantier, R., Akiyama, S. K., Olden, K., Roberts, J. D. (2000) Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway. J. Biol. Chem. 275, 11284-11290.
23. Rao, G. N., Baas, A. S., Glasgow, W. C., Eling, T. E., Runge, M. S., Alexander, R. W. (1994) Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells. J. Biol. Chem. 269, 32586-32591.
24. Rizzo, M. T., Carlo-Stella, C. (1996) Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha-induced activation of the c-jun amino-terminal kinases in stromal cells. Blood 88, 3792-3800.
25. Chang, L. C., Wang, J. P. (2000) The upstream regulation of p38 mitogen-activated protein kinase phosphorylation by arachidonic acid in rat neutrophils. J. Pharm. Pharmacol. 52, 539-546.
26. Capodici, C., Pillinger, M. H., Han, G., Philips, M. R., Weissmann, G. (1998) Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase-dependent pathway. J. Clin. Invest. 102, 165-175.
27. Werz, O., Brungs, M., Steinhilber, D. (1996) Purification of transforming growth factor betal from human platelets. Pharmazie 51, 893-896.
28. Brungs, M., Rådmark, O., Samuelsson, B., Steinhilber, D. (1995) Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D-3. Proc. Natl. Acad. Sci. USA 92, 107-111.
29. Böyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest.Suppl. 97, 77-89.
30. Werz, O., Steinhilber, D. (1996) Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells - the presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. Eur. J. Biochem. 242, 90-97.
31. Grynkiewiz, G., Poenie, M., Tsien, R. Y. (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
32. Surette, M. E., Dallaire, N., Jean, N., Picard, S., Borgeat, P. (1998) Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils. FASEB J. 12, 1521-1531.
33. Hammarberg, T., Rådmark, O. (1999) 5-Lipoxygenase binds calcium. Biochemistry 38, 4441-4447.
34. Skorey, K. I., Gresser, M. J. (1998) Calcium is not required for 5-lipoxygenase activity at high phosphatidyl choline vesicle concentrations. Biochemistry 37, 8027-8034.
35. Reddy, K. V., Hammarberg, T., Rådmark, O. (2000) Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid. Biochemistry 39, 1840-1848.
36. Aharony, D., Stein, R. L. (1986) Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase. J. Biol. Chem. 261, 11512-11519.
37. Gijon, M. A., Leslie, C. C. (1999) Regulation of arachidonic acid release and cytosolic phospholipase A2 activation. J. Leukoc. Biol. 65, 330-336.
38. Edwards, A. S., Newton, A. C. (1997) Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J. Biol. Chem. 272, 18382-18390.
39. Fiore, S., Serhan, C. N. (1990) Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J. Exp. Med. 172, 1451-1457.
40. Chang, L. C., Wang, J. P. (2001) Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils. J. Leukoc. Biol. 69, 659-665.
41. Falgueyret, J. P., Hutchinson, J. H., Riendeau, D. (1993) Criteria for the identification of non-redox inhibitors of 5-lipoxygenase. Biochem. Pharmacol. 45, 978-981.
42. Percival, M. D., Denis, D., Riendeau, D., Gresser, M. J. (1992) Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Eur. J. Biochem. 210, 109-117.