Identification of a novel human angiopoietin-like gene expressed mainly in heart

Journal of Human Genetics

Volumn 48, Issue 3, 2003, Pages 159-162

  Zeng, Li ^a   Dai, Jianliang ^a   Ying, Kang ^a   Zhao, Enpeng ^a   Jin, Wei ^a   Ye, Yin ^a   Dai, Jianfeng ^a   Xu, Jian ^a   Xie, Yi ^a   Mao, Yumin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Angiopoietin; ANGPTL5; Coiled coil domain; Fibrinogenlike domain; Heart

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 5; COMPLEMENTARY DNA; DNA; FIBRINOGEN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN LIKE 5; ANGIOPOIETIN RECEPTOR; ANGIOPOIETIN RELATED PROTEIN; ANGIOPOIETIN RELATED PROTEIN 4; DNA POLYMERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ADULT; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 11Q; DNA LIBRARY; DNA SEQUENCE; GENE IDENTIFICATION; GENE MAPPING; HEART; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; ANGIOGENESIS; CHROMOSOME 11Q22; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; FETUS; GENE EXPRESSION; GENETIC DATABASE; HEART TISSUE; HUMAN GENOME; INTRON; PROTEIN CLEAVAGE; PROTEIN FUNCTION;

EUKARYOTA;

EID: 0037237127     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380300025     Document Type: Article

References (15)

1. Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB (1999) Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62:477-482
2. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewske C, Maisonpierre PC, Yancopoulos GD (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by scretion-trap expression cloning. Cell 87:1161-1169
3. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364
4. Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem 275:28488-28493
5. Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Kon GY (1999a) Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. FEBS Lett 443:353-356
6. Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (1999b) Molecular cloning, expression, and characterization of angiopoietin-related protein. Angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem 274:26523-26528
7. Kim I, Kim HG, Kim H, Kim HH, Park SK, Uhm CS, Lee ZH, Koh GY (2000) Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J 346:603-610
8. Koishi R, Ando Y, Ono M, Shimamura M, Yasumo H, Fujiwara T, Horikoshi H, Furukawa H (2002) Angptl3 regulates lipid metabolism in mice. Nat Genet 30:151-157
9. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55-60
10. Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (1999) Angiopoietin-3, a novel member of the angiopoietin family. FEBS Lett 448:254-256
11. Shimizugawa T, Ono M, Shimamura M, Yoshida K, Ando Y, Koishi R, Ueda K, Inaba T, Minekura H, Kohama T, Furukawa H (2002) ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J Biol Chem 277:33742-33748
12. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171-1180
13. Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (1999) Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci USA 96:1904-1909
14. Xu J, Zhou Z, Zeng L, Huang Y, Zhao W, Cheng C, Xu M, Xie Y, Mao Y (2001) Cloning, expression and chracterization of a novel human REPS1 gene. Biochem Biophys Acta 1522:118-121
15. Yoshida K, Shimizugawa T, Ono M, Furukawa H (2002) Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res 43:1770-1772