A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans

Development

Volumn 130, Issue 1, 2003, Pages 57-69

  Moghal, Nadeem ^a   Sternberg, Paul W ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

C. elegans; DPY 22; EGF; LET 23; Mediator; RAS; SOP 1; Vulva

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMINE; PROTEIN TYROSINE KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR; WNT PROTEIN;

CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME REGULATION; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOSS; GENE MUTATION; GENETIC REGULATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; INHIBITION KINETICS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; VULVA;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOSKELETAL PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTAMINE; HELMINTH PROTEINS; HERMAPHRODITISM; MALE; MUTATION; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTION FACTORS; VULVA;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; NEMATODA;

EID: 0037236896     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00189     Document Type: Review

References (76)

1. Aroian, R. and Sternberg, P. (1991). Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics 128, 251-267.
2. Aroian, R. V., Koga, M., Mendel, J. E., Ohshima, Y. and Sternberg, P. W. (1990). The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693-699.
3. Avery, L., Bargmann, C. and Horvitz, H. (1993). The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics 134, 455-464.
4. Bargmann, C. and Avery, L. (1995). Laser killing of cells in Caenorhabditis elegans. Methods in Cell Biology. Caenorhabditis elegans: Modern Biological Analysis of an Organism. Vol. 48 (ed. H. F. Epstein and D. C. Shakes), pp. 225-250. San Diego: Academic Press.
5. Beitel, G., Clark, S. and Horvitz, H. (1990). Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348, 503-509.
6. Beitel, G., Tuck, S., Greenwald, I. and Horvitz, H. (1995). The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9, 3149-3162.
7. Berset, T., Hoier, E. F., Battu, G., Canevascini, S. and Hajnal, A. (2001). Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science 291, 1055-1058.
8. Berti, L., Mittler, G., Przemeck, G. K., Stelzer, G., Gunzler, B., Amati, F., Conti, E., Dallapiccola, B., Hrabe de Angelis, M., Novelli, G. et al. (2001). Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. Genomics 74, 320-332.
9. Boube, M., Joulia, L., Cribbs, D. L. and Bourbon, H. M. (2002). Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110, 143-151.
10. Boyer, T. G., Martin, M. E., Lees, E., Ricciardi, R. P. and Berk, A. J. (1999). Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 399, 276-279.
11. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
12. Chang, C., Hopper, N. and Sternberg, P. (2000). Caenorhabditis elegans SOS-1 is necessary for multiple Ras-mediated developmental signals. EMBO J. 19, 3283-3294.
13. Chen, Z. and Han, M. (2001). C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr. Biol. 11, 1874-1879.
14. Clandinin, T., Katz, W. and Sternberg, P. (1997). Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal. Dev. Biol. 182, 150-161.
15. Cox, G., Laufer, J., Kusch, M. and Edgar, R. (1980). Genetic and phenotypic characterization of roller mutants of C. elegans. Genetics 95, 317-339.
16. Eisenmann, D., Maloof, J., Simske, J., Kenyon, C. and Kim, S. (1998). The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development 125, 3667-3680.
17. Emerson, B. M. (2002). Specificity of gene regulation. Cell 109, 267-270.
18. Ferguson, E. and Horvitz, H. (1985). Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode C. elegans. Genetics 110, 17-72.
19. Ferguson, E. and Horvitz, H. (1989). The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics 123, 109-121.
20. Ferguson, E., Sternberg, P. and Horvitz, H. (1987). A genetic pathway for the specification of the vulval cell lineages of C. elegans. Nature 326, 259-267.
21. Gleason, J. E., Korswagen, H. C. and Eisenmann, D. M. (2002). Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes Dev. 16, 1281-1290.
22. Granato, M., Schnabel, H. and Schnabel, R. (1994). pha-1, a selectable marker for gene-transfer in C. elegans. Nucleic Acids Res. 22, 1762-1763.
23. Greenwald, I. (1997). Development of the vulva. In C. Elegans II (ed. D. L. Riddle, T. Blumenthal, B. J. Meyer and J. R. Priess), pp. 519-541. Cold Spring Harbor, NY: Cold Spring Habor Laboratory Press.
24. Gustafsson, C. M. and Samuelsson, T. (2001). Mediator - a universal complex in transcriptional regulation. Mol. Microbiol. 41, 1-8.
25. Hajnal, A., Whitfield, C. and Kim, S. (1997). Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev. 11, 2715-2728.
26. Han, M. and Sternberg, P. (1990). let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63, 921-931.
27. Hengartner, C. J., Thompson, C. M., Zhang, J., Chao, D. M., Liao, S. M., Koleske, A. J., Okamura, S. and Young, R. A. (1995). Association of an activator with an RNA polymerase II holoenzyme. Genes Dev. 9, 897-910.
28. Herman, R. (1978). Crossover suppressors and balanced recessive lethals in C. elegans. Genetics 88, 49-65.
29. Hill, R. and Sternberg, P. (1992). The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature 358, 470-476.
30. Hodgkin, J., Horvitz, H. and Brenner, S. (1979). Nondisjunction mutants of the nematode C. elegans. Genetics 91, 67-94.
31. Holstege, F. C., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S. and Young, R. A. (1998). Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95, 717-728.
32. Hopper, N., Lee, J. and Sternberg, P. (2000). ARK-1 inhibits EGFR signaling in C. elegans. Mol. Cell 6, 65-75.
33. Huang, L., Tzou, P. and Sternberg, P. (1994). The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol. Biol. Cell 5, 395-411.
34. Ito, M., Yuan, C. X., Malik, S., Gu, W., Fondell, J. D., Yamamura, S., Fu, Z. Y., Zhang, X., Qin, J. and Roeder, R. G. (1999). Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3, 361-370.
35. Jongeward, G., Clandinin, T. and Sternberg, P. (1995). sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics 139, 1553-146.
36. Kaech, S., Whitfield, C. and Kim, S. (1998). The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94, 761-771.
37. Katz, W., Hill, R., Clandinin, T. and Sternberg, P. (1995). Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82, 297-307.
38. Katz, W., Lesa, G., Yannoukakos, D., Clandinin, T., Schlessinger, J. and Sternberg, P. (1996). A point mutation in the extracellular domain activated LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol. Cell. Biol. 16, 529-537.
39. Korswagen, H. C., Coudreuse, D. Y., Betist, M. C., van de Water, S., Zivkovic, D. and Clevers, H. C. (2002). The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 16, 1291-1302.
40. Kwon, J., Park, J., Gim, B., Han, S., Lee, J. and Kim, Y. (1999). Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Proc. Natl. Acad. Sci. USA 96, 14990-14995.
41. Kwon, J. Y., Kim-Ha, J., Lee, B. J. and Lee, J. (2001). The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans. FEBS Lett. 508, 305-308.
42. Kwon, J. Y. and Lee, J. (2001). Biological significance of a universally conserved transcription mediator in metazoan developmental signaling pathways. Development 128, 3095-3104.
43. Lackner, M., Kornfeld, K., Miller, L., Horvitz, H. and Kim, S. (1994). A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes Dev. 8, 160-173.
44. Lee, J., Jongeward, G. and Sternberg, P. (1994). unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev. 8, 60-73.
45. Liao, S. M., Zhang, J., Jeffery, D. A., Koleske, A. J., Thompson, C. M., Chao, D. M., Viljoen, M., van Vuuren, H. J. and Young, R. A. (1995). A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374, 193-196.
46. Lu, X. and Horvitz, H. (1998). lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95, 981-991.
47. Maloof, J. and Kenyon, C. (1998). The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development 125, 181-190.
48. Maloof, J., Whangbo, J., Harris, J., Jongeward, G. and Kenyon, C. (1999). A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans. Development 126, 37-49.
49. Meneely, P. and Wood, W. (1987). Genetic analysis of X-chromosome dosage compensation in C. elegans. Genetics 117, 25-41.
50. Myer, V. E. and Young, R. A. (1998). RNA polymerase II holoenzymes and subcomplexes. J. Biol. Chem. 273, 27757-27760.
51. Myers, L. C., Gustafsson, C. M., Hayashibara, K. C., Brown, P. O. and Kornberg, R. D. (1999). Mediator protein mutations that selectively abolish activated transcription. Proc. Natl. Acad. Sci. USA 96, 67-72.
52. Myers, L. C. and Kornberg, R. D. (2000). Mediator of transcriptional regulation. Annu. Rev. Biochem. 69, 729-749.
53. Nagase, T., Seki, N., Ishikawa, K., Tanaka, A. and Nomura, N. (1996). Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 3, 17-24.
54. Narlikar, G. J., Fan, H. Y. and Kingston, R. E. (2002). Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475-487.
55. Philibert, R. A., King, B. H., Winfield, S., Cook, E. H., Lee, Y. H., Stubblefield, B., Damschroder-Williams, P., Dea, C., Palotie, A., Tengstrom, C. et al. (1998). Association of an X-chromosome dodecamer insertional variant allele with mental retardation. Mol. Psychiatry 3, 303-309.
56. Rogalski, T. and Riddle, D. (1988). A C. elegans RNA polymerase II gene, aura-1 IV, and nearby essential genes. Genetics 118, 61-74.
57. Sigurdson, D., Spanier, G. and Herman, R. (1984). Caenorhabditis elegans deficiency mapping. Genetics 108, 331-345.
58. Simske, J. and Kim, S. (1995). Sequential signaling during Caenorhabditis elegans vulval induction. Nature 375, 142-146.
59. Simske, J., Kaech, S., Harp, S. and Kim, S. (1996). LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell 85, 195-204.
60. Singh, N. and Han, M. (1995). sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Genes Dev. 9, 2251-2265.
61. Solari, F. and Ahringer, J. (2000). NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr. Biol. 10, 223-226.
62. Sternberg, P. and Han, M. (1998). Genetics of RAS signaling in C. elegans. Trends Genet. 14, 466-472.
63. Sternberg, P. and Horvitz, H. (1986). Pattern formation during vulval development in C. elegans. Cell 44, 761-772.
64. Sternberg, P. and Horvitz, H. (1989). The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 58, 679-693.
65. Sundaram, M. and Han, M. (1995). The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83, 889-901.
66. Treisman, J. (2001). Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development 128, 603-615.
67. Trent, C., Tsung, N. and Horvitz, H. (1983). Egg-laying defective mutants of the nematode C. elegans. Genetics 104, 619-647.
68. Wang, M. and Sternberg, P. (1999). Competence and commitment of Caenorhabditis elegans vulval precursor cells. Dev. Biol. 212, 12-24.
69. White, J., Southgate, E. and Thomson, J. (1992). Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons. Nature 355, 838-841.
70. Wicks, S. R., Yeh, R. T., Gish, W. R., Waterston, R. H. and Plasterk, R. H. (2001). Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat. Genet. 28, 160-164.
71. Woychik, N. A. and Hampsey, M. (2002). The RNA polymerase II machinery: structure illuminates function. Cell 108, 453-463.
72. Wu, Y. and Han, M. (1994). Suppression of activated Let-60 Ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev. 8, 147-159.
73. Yochem, J., Weston, K. and Greenwald, I. (1988). The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature 335, 547-550.
74. Yoon, C., Lee, J., Jongeward, G. and Sternberg, P. (1995). Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 269, 1102-1105.
75. Zhang, H. and Emmons, S. (2000). A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene. Genes Dev. 14, 2161-2172.
76. Zhang, H. and Emmons, S. W. (2002). Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex. Genetics 160, 799-803.