Wortmannin enhances the induction of micronuclei by low and high LET radiation

Mutagenesis

Volumn 18, Issue 1, 2003, Pages 37-44

  Oliveira, N G ^a,b   Castro, M ^b,c   Rodrigues, A S ^a,d   Goncalves I C ^e   Gil, O M ^a,e   Fernandes, A P ^e   Toscano Rico, J M ^c   Rueff, J ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^d UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIAS   (Portugal)

^e INSTITUTO TECNOLÓGICO E NUCLEAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BORON; COBALT 60; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; RADIOSENSITIZING AGENT; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL NUCLEUS; CELL STRAIN V 79; CHINESE HAMSTER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINESIS; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVATION; GAMMA RADIATION; GENOTOXICITY; IONIZING RADIATION; LINEAR ENERGY TRANSFER; LOW ENERGY RADIATION; MAMMAL CELL; MICRONUCLEUS; MICRONUCLEUS TEST; NEUTRON CAPTURE THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RADIATION CARCINOGENESIS; RADIATION ENERGY; RADIOSENSITIZATION;

ALPHA PARTICLES; ANDROSTADIENES; ANIMALS; BORON; CELL LINE; CHROMOSOME BREAKAGE; COBALT RADIOISOTOPES; CRICETINAE; CRICETULUS; DNA; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FIBROBLASTS; GAMMA RAYS; LINEAR ENERGY TRANSFER; MICRONUCLEUS TESTS; NEUTRONS; PROTEIN-SERINE-THREONINE KINASES; RADIATION-SENSITIZING AGENTS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0037236752     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/18.1.37     Document Type: Article

References (42)

1. Blakely,E.A. and Kronenberg,A. (1998) Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat. Res., 150, S126-S145.
2. Boulton,S., Kyle,S., Yalcintepe,L. and Durkacz,B.W. (1996) Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis, 17, 2285-2290.
3. Boulton,S., Kyle,S. and Durkacz,B.W. (1999) Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage. Carcinogenesis, 20, 199-203.
4. Britten,R.A., Peters,L.J. and Murray,D. (2001) Biological factors influencing the RBE of neutrons: implications for their past, present and future use in radiotherapy. Radiat. Res., 156, 125-135.
5. Busse,P.M., Zamenhof,R., Madoc-Jones,H., Solares,G., Kiger,S., Riley,K., Chuang,C., Rogers,G. and Harling,O. (1997) Clinical follow-up of patients with melanoma of the extremity treated in a phase I boron neutron capture therapy protocol. In Larsson,B., Crawford,J. and Weinreich,R. (eds), Medicine and Physics, Vol. I, Advances in Neutron Capture Therapy. Elsevier Science, Amsterdam, The Netherlands, pp. 60-64.
6. Caria,H., Chaveca,T., Laires,A. and Rueff,J. (1995) Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochore-containing (CREST staining) micronuclei in human lymphocytes. Mutat. Res., 343, 85-94.
7. Charlton,D.E. (1991) Energy deposition in small ellipsoidal volumes by high-LET particles: application to thermal neutron dosimetry. Int. J. Radiat. Biol., 59, 827-842.
8. Chernikova,S.B., Wells,R.L. and Elkind,M.M. (1999) Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat. Res., 151, 159-166.
9. Chernikova,S.B., Lindquist,K.L. and Elkind,M.M. (2001) Cell cycle-dependent effects of wortmannin on radiation survival and mutation. Radiat. Res., 155, 826-831.
10. Chu,G. (1997) Double strand break repair. J. Biol. Chem., 272, 24097-24100.
11. Coderre,J.A and Morris,G.M. (1999) The radiation biology of boron neutron capture therapy. Radiat. Res., 151, 1-18.
12. Critchlow,S.E. and Jackson,S.P. (1998) DNA end-joining: from yeast to man. Trends Biochem. Sci., 23, 394-398.
13. Davies,S.P., Reddy,H., Caivano,M. and Cohen,P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J., 351, 95-105.
14. DiBiase,S.J., Zeng,Z.C., Chen,R., Hyslop,T., Curran, W.J.,Jr and Iliakis,G. (2000) DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res., 60, 1245-1253.
15. Featherstone,C. and Jackson,S.P. (1999) DNA double-strand break repair. Curr. Biol., 9, R759-R761.
16. Fenech,M. (2000) The in vitro micronucleus technique. Mutat. Res., 455, 81-95.
17. Gil,O.M., Oliveira,N.G., Rodrigues,A.S., Laires,A., Ferreira,T.C., Limbert,E., Léonard,A., Gerber,G. and Rueff,J. (2000) Cytogenetic alterations and oxidative stress in thyroid cancer patients after iodine-131 therapy. Mutagenesis, 15, 69-75.
18. Gonçalves,I.C., Ramalho,A.G., Gonçalves,I.F., Salgado,J., Pertusa,J., Irles,A., Mascarenhas,F., Castro,M., Vale,F., Toscano-Rico,J. and Alcober,V. (1999) Work in the field of BNCT using the Portuguese Research Reactor. J. Radioanal. Nucl. Chem., 240, 431-432.
19. Goodhead,D.T. (1989) The initial physical damage produced by ionizing radiations. Int. J. Radiat. Biol., 56, 623-634.
20. Gupta,N., Gahbauer,R.A., Blue,T.E. and Wambersie,A. (1994) Dose prescription in boron neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys., 28, 1157-1166.
21. Hatanaka,H. and Nakagawa,Y. (1994) Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys., 28, 1061-1066.
22. Hartley,K.O., Gell,D., Smith,G.C., Zhang,H., Divecha,N., Connelly,M.A., Admon,A., Lees-Miller,S.P., Anderson,C.W. and Jackson,S.P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell, 82, 849-856.
23. Hawthorne,M.F. (1993) The role of chemistry in the development of boron neutron capture therapy of cancer. Angew. Chem. Int. Ed., 32, 950-984.
24. Hei,T.K., Zhao,Y.L., Roy,D., Piao,C.Q., Calaf,G. and Hall,E.J. (2001) Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. Adv. Space Res., 27, 411-419.
25. Hosoi,Y., Miyachi,H., Matsumoto,Y., Ikehata,H., Komura,J., Ishii,K., Zhao,H.J., Yoshida,M., Takai,Y., Yamada,S., Suzuki,N. and Ono,T. (1998) A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer, 78, 642-647.
26. Kinashi,Y., Sakurai,Y., Masunaga,S., Takagaki,M. and Ono,K. (2001) Sensitizing effect of the phosphatidylinositol 3-kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound. Radiat. Med., 19, 27-32.
27. Lucke-Huhle,C. (1994) Similarities between human ataxia fibroblasts and murine SCID cells: high sensitivity to gamma rays and high frequency of methotrexate-induced DHFR gene amplification, but normal radiosensitivity to densely ionizing alpha particles. Radiat. Environ. Biophys., 33, 201-210.
28. Martensson,S. and Hammarsten,O. (2002) DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends. J. Biol. Chem., 277, 3020-3029.
29. Mishima,Y, Honda,C., Ichihashi,M., Obara,H., Hiratsuka,J., Fukuda,H., Karashima,H., Kobayashi,T., Kanda,K. and Yoshino,K. (1989) Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet, ii, 388-389.
30. Mishima,Y. (1997) Melanoma and nonmelanoma neutron capture therapy using gene therapy: Overview. In Larsson,B., Crawford,J. and Weinreich,R. (eds), Medicine and Physics. Vol. I, Advances in Neutron Capture Therapy. Elsevier Science, Amsterdam, The Netherlands, pp. 10-25.
31. Nagasawa,H., Little,J.B., Inkret,W.C., Carpenter,S., Raju,M.R., Chen,D.J. and Strniste,G.F. (1991) Response of X-ray-sensitive CHO mutant cells (xrs-6c) to radiation. II. Relationship between cell survival and the induction of chromosomal damage with low doses of alpha particles. Radiat. Res., 126, 280-288.
32. Okayasu,R., Suetomi,K. and Ullrich,R.L. (1998) Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Radiat. Res., 149, 440-445.
33. Oliveira,N.G., Castro,M., Rodrigues,A.S., Goncalves,I.C., Cassapo,R., Fernandes,A.P., Chaveca,T., Toscano-Rico,J.M. and Rueff,J. (2001) Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay. Mutagenesis, 16, 369-375.
34. Pfeiffer,P., Goedecke,W. and Obe,G. (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 15, 289-302.
35. Price,B.D. and Youmell,M.B. (1996) The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res., 56, 246-250.
36. Prise,K.M., Pinto,M., Newman,H.C. and Michael,B.D. (2001) A review of studies of ionizing radiation-induced double-strand break clustering. Radiat. Res., 156, 572-576.
37. Rosenzweig,K.E., Youmell,M.B., Palayoor,S.T. and Price,B.D. (1997) Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY2940002 correlates with the inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin. Cancer Res., 3, 1149-1156.
38. Sarkaria,J.N., Tibbetts,R.S., Busby,E.C., Kennedy,A.P., Hill,D.E. and Abraham,R.T. (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58, 4375-4382.
39. Schwartz,J.L. and Hsie,A.W. (1997) Genetic and cytogenetic markers of exposure to high-linear energy transfer radiation. Radiat. Res., 148, S87-S92.
40. Shadley,J.D., Whitlock,J.L., Rotmensch,J., Atcher,R.W, Tang,J. and Schwartz,J.L. (1991) The effects of radon daughter alpha-particle irradiation in K1 and xrs-5 CHO cell lines. Mutat. Res., 248, 73-83.
41. Van Hummelen,P. and Kirsh-Volders,M. (1990) An improved method for the 'in vitro' micronucleus using human lymphocytes. Mutagenesis, 5, 203-204.
42. Zhao,Y.L., Piao,C.Q., Hall,E.J. and Hei,T.K. (2001) Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. Radiat. Res., 155, 230-234.